Transcriptomics News and Research

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Researchers use single-cell sequencing to identify cell types that occur in pancreatic tumors

Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and Innovation Institute, an international team of researchers have described in detail the individual cells that comprise the pancreatic cancer microenvironment, a critical step in devising new treatment options for patients with this aggressive and difficult-to-treat disease.

1 Oct 2020

New tool enables big data analysis without specialized expertise in bioinformatics

A new data analysis tool developed by researchers at The University of Texas MD Anderson Cancer Center incorporates a user-friendly, natural-language interface to allow biomedical researchers without specialized expertise in bioinformatics or programming languages to conduct intuitive analysis of large datasets.

25 Sep 2020

Exercise hormone could have a therapeutic effect on COVID-19 patients

A study conducted by researchers at São Paulo State University suggests that irisin, a hormone secreted from muscles in response to exercise, could have a therapeutic effect on COVID-19 patients.

22 Sep 2020

Discovering a molecule that could interfere with SARS-CoV-2 replication

In this interview, News-Medical speaks to Stepan Nersisyan about his discovery of a molecule that could replicate SARS-CoV-2.

22 Sep 2020

Researchers and clinicians share findings on ovarian cancer

After nearly four years of work, a group of researchers and clinicians from the University of Colorado (CU) published a paper this week in the Clinical Cancer Research that shares findings from research looking at how the composition of ovarian cancer tumors changes during chemotherapy and contributes to therapeutic response.

16 Sep 2020

Study shows what happens in the fetal brain affected by congenital Zika syndrome

Zika virus infection during pregnancy can cause severe abnormalities in the fetus, including malformations such as microcephaly.

3 Sep 2020

ACE2/TMPRSS2 not expressed in pancreatic islet endocrine cells

A new study by researchers at the Vanderbilt University Medical Center and the University of Pennsylvania Perelman School of Medicine and published on the preprint server bioRxiv* in August 2020 reports that both key enzymes that are required for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the human host cell are lacking in the beta cells of the pancreatic islet. This rules out the direct injury hypothesis for impaired glucose control in patients with COVID-19 disease.

1 Sep 2020

Exosomes: The cancer cell communication mechanism

Professor Deborah Goberdhan speaks to News-Medical about her team's latest research into cancer cells, and the mechanisms they use to communicate.

26 Aug 2020

Combining expertise in organoids and sequencing technologies for ALS research

MDC researchers received a $150,000 pilot project grant from the Chan Zuckerberg Initiative's Neurodegeneration Challenge Network to investigate a defining feature of amyotrophic lateral sclerosis (ALS).

20 Aug 2020

Membrane nanoparticles acts as a bait to trap SARS-CoV-2

In an exciting new bioRxiv preprint research paper, Chinese researchers describe the development of membrane nanoparticles from ACE2-rich cells with a potent capacity to block the adherence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Aug 2020

Study provides comprehensive update on ACE2 enzyme with key role in SARS-CoV-2 infection

Researchers at Uppsala University have described the presence, throughout the human body, of the enzyme ACE2.

5 Aug 2020

New method reveals the dynamics of cell development and gene activity

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only rather than time-lapse films.

4 Aug 2020

Study reveals multiple characteristics of HIV-1-producing cells in vivo

For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo.

29 Jul 2020

Amyloid plaques may act as trigger for Alzheimer's disease

The brains of people living with Alzheimer's are riddled with plaques: protein aggregates consisting mainly of amyloid-beta.

23 Jul 2020

Drug discovery pipeline to exploit transcription factors for cancer therapy

Cancer is a leading cause of death and one of the most complex challenges to modern medicine. By employing cutting-edge technologies that precisely measure the effects of candidate targets and drugs on the fundamental process of transcription, the new start-up company QUANTRO Therapeutics strives to radically change the precision and scope of cell-based drug screening.

21 Jul 2020

An abundance of biomolecules linked to COVID-19 status and severity

Tapping into the potential of the multi-omic method to uncover functional connections between various classes of biomolecules, researchers from notable institutions in the United States have discovered sets of co-varying molecules that shed light on coronavirus disease (COVID-19) pathophysiology and provide treatment opportunities.

20 Jul 2020

Use of whole blood transcriptomes may improve COVID-19 diagnosis and treatment

In a new paper published on the preprint server medRxiv*, a multinational group of researchers provide the first evidence for the use of whole blood transcriptomics to distinguish coronavirus disease (COVID-19) from other infections, and also to monitor and potentially predict disease outcomes.

9 Jul 2020

Researchers develop new atlas for mapping brain regions

In a new study researchers at Karolinska Institutet and KTH Royal Institute of Technology in Sweden have developed a new kind of brain atlas based on an innovative method of mapping brain tissue into areas according to their molecular profile

29 Jun 2020

SARS-CoV-2 can replicate in human pediatric gastric organoids

A diverse research group from the United Kingdom, Italy, China, and Australia established a first expandable human gastric organoid culture across fetal developmental stages, supporting the hypothesis that fetal tissue seems to be much less susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection – especially in the early stages of development.

25 Jun 2020