Preclinical News and Research

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The Power of Digitalization in the Life Sciences and Diagnostics Sectors

In this interview, News-Medical talks to Frank Buescher and Wael Yared about the increasing digitalization of the life sciences and diagnostics sectors and the possibilities this entails.

From Tecan 19 Nov 2021

Study involving a rat model offers potential treatment for Alexander disease

Alexander disease is a progressive and rare neurological disorder with no cure or standard course of treatment. But a new study led by researchers at the University of Wisconsin–Madison involving a rat model of the disease offers a potential treatment for the typically fatal condition.

18 Nov 2021

New mothers' placenta could help reduce brain injury in other growth-restricted babies

The placenta from mothers of healthy newborns could one day be used to reduce brain injury in growth-restricted babies, according to University of Queensland research.

18 Nov 2021

Short-term severe calorie restriction safe, feasible, and well tolerated by cancer patients

A diet involving short-term, severe calorie restriction was safe, feasible, and resulted in a decrease of blood glucose and growth factor concentration, reduction in peripheral blood immunosuppressive cells, and enhanced intratumor T-cell infiltration in cancer patients receiving standard-of-care therapy, according to the results of a clinical trial.

18 Nov 2021

3D cell culturing platform allows study of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a deadly and rapidly progressing disease with no cure. The disease involves abnormal interactions between lung cells, including fibroblasts, and their surrounding environment.

16 Nov 2021

Tighter blood pressure management may lead to better spinal cord injury recovery

Patients with new spinal cord injuries whose blood pressure is maintained within a newly defined range during surgery may stand a better chance of regaining some mobility and functionality – even in patients with the most devastating injuries – according to a new study by researchers at UC San Francisco.

16 Nov 2021

Researchers develop a highly efficient method to generate immune cells for cancer therapies

A Ludwig Cancer Research study has devised a highly efficient method to generate large numbers of immune cells specifically engineered to recognize neoantigens - small fragments of randomly mutated proteins that are typically unique to a patient's cancer - and destroy the tumors that express them.

15 Nov 2021

Expert explores how our sleeping patterns can be linked to cognitive decline

Dr Greg Elder, Senior Lecturer in Psychology and Associate Director of Northumbria Sleep Research explores why a good night's sleep is important and how our sleeping patterns can be linked to conditions like dementia for The Conversation.

15 Nov 2021

Study assesses whether medicinal mushrooms and Chinese herbs can help treat COVID-19

A novel study is assessing whether medicinal mushrooms and Chinese herbs provide therapeutic benefit in treating acute COVID-19 infection.

12 Nov 2021

NanoTCE technology shows promise for treatment of acute myeloid leukemia

Oncotarget published "Nanoparticle T cell engagers for the treatment of acute myeloid leukemia" which reported that Acute myeloid leukemia (AML) is the most common type of leukemia and has a 5-year survival rate of 25%.

12 Nov 2021

SARS-CoV-2 self-amplifying mRNA vaccine demonstrates cellular and humoral immune responses

Researchers from the US recently reported the preclinical development of a self-amplifying mRNA (SAM) vaccine that encodes a prefusion-stabilized SARS-CoV-2 spike glycoprotein.

12 Nov 2021

New target for drug development could fill a major gap in depression treatment

Vanderbilt researchers found that ketamine's rapid antidepressant action is due to specific synaptic effects.

10 Nov 2021

ACTG announces launch of clinical trial evaluating a three-month TB treatment

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, today announced the launch of A5362 (CLO-FAST), a clinical trial studying a three-month clofazimine- and high-dose rifapentine-containing treatment regimen for people with drug-susceptible tuberculosis (TB).

10 Nov 2021

Inhibiting epigenetic modification could be key to reducing cancer metastasis

Fatty acid uptake produces an epigenetic modification that is required for cancer metastasis, according to a study published in Nature.

10 Nov 2021

A measles-vectored COVID-19 vaccine induces strong immunity in animal model

A new study explores the potential of MV-based vaccines targeting the S protein of SARS-CoV-2.

9 Nov 2021

Researchers identify safety concerns with neuroblastoma candidate drug

St. Jude Children's Research Hospital scientists looking for drugs to improve survival of children with high-risk neuroblastoma found a promising candidate in CX-5461.

9 Nov 2021

SBIR grant awarded to develop treatment for alcoholic liver disease-associated hepatorenal syndrome

The Institute of Human Virology (IHV) at the University of Maryland School of Medicine and MitoPower LLC were awarded an SBIR (Small Business Innovation Research) grant of up to $6.5 million over five years from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism.

9 Nov 2021

Arginine treatment enhances effectiveness of radiation therapy in cancer patients with brain metastases

Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial from investigators at Weill Cornell Medicine and Angel H. Roffo Cancer Institute.

7 Nov 2021

Key link between chronic stress and cancer discovered

Stress can have a significant negative effect on health, but our understanding of how stress impacts the development and progression of cancer is just beginning.

6 Nov 2021

Pre-clinical follow-up study boosting with original formulation and next generation INO-4802 SARS-CoV-2 vaccine candidate

Researchers describe the antibody-inducing effects of DNA-based synthetic vaccines INO-4800 and INO-4802 against SARS-CoV-2 in non-human primates.

3 Nov 2021

Preclinical News and Research

The Power of Digitalization in the Life Sciences and Diagnostics Sectors

Study involving a rat model offers potential treatment for Alexander disease

New mothers' placenta could help reduce brain injury in other growth-restricted babies

Short-term severe calorie restriction safe, feasible, and well tolerated by cancer patients

3D cell culturing platform allows study of idiopathic pulmonary fibrosis

Tighter blood pressure management may lead to better spinal cord injury recovery

Researchers develop a highly efficient method to generate immune cells for cancer therapies

Expert explores how our sleeping patterns can be linked to cognitive decline

Study assesses whether medicinal mushrooms and Chinese herbs can help treat COVID-19

NanoTCE technology shows promise for treatment of acute myeloid leukemia

SARS-CoV-2 self-amplifying mRNA vaccine demonstrates cellular and humoral immune responses

New target for drug development could fill a major gap in depression treatment

ACTG announces launch of clinical trial evaluating a three-month TB treatment

Inhibiting epigenetic modification could be key to reducing cancer metastasis

A measles-vectored COVID-19 vaccine induces strong immunity in animal model

Researchers identify safety concerns with neuroblastoma candidate drug

SBIR grant awarded to develop treatment for alcoholic liver disease-associated hepatorenal syndrome

Arginine treatment enhances effectiveness of radiation therapy in cancer patients with brain metastases

Key link between chronic stress and cancer discovered

Pre-clinical follow-up study boosting with original formulation and next generation INO-4802 SARS-CoV-2 vaccine candidate

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