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Wireless medical device might help with weight loss

Gastric bypass surgery is sometimes the last resort for those who struggle with obesity or have serious health-related issues due to their weight.

8 Jan 2021

Are SARS-CoV-2 antibodies associated with disease enhancement?

As SARS-CoV-2 continues to wreak its havoc, antibodies that neutralize the virus and protect against infection have become an important focus of research. However, there is a concern as to whether these antibodies can actually enhance the disease.

6 Jan 2021

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue.

5 Jan 2021

Replacing the RNA strand with DNA may enhance efficacy of ASO-based drugs

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a heteroduplex oligonucleotide (HDO) model, have demonstrated augmentation of ASO-based drugs by replacing the RNA strand with DNA.

5 Jan 2021

Novel imaging method reveals in vivo localization of antibiotics in infected lung tissues

Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues.

5 Jan 2021

P2 COVID-19 study shows no material safety differences between opaganib and control arms

Preliminary data from the non-powered U.S. Phase 2 study of 40 hospitalized patients shows that orally-administered opaganib was safe, with no material safety differences between opaganib and control arms.

4 Jan 2021

New device for investigating intrinsic extracellular pH dynamics in the brain

Researchers at Tohoku University have developed the first all-in-one miniature pH probe for real-time investigations of intrinsic extracellular pH dynamics in the deep brain structures.

24 Dec 2020

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

In a new study, released on the bioRxiv* preprint server, a team of researchers explores the antiviral potential of red blood cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19.

24 Dec 2020

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

As the world struggles to contain the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for over 1.6 million deaths and 76 million infections globally, researchers are trying to pin down the determinants of lethality, of infectivity and of protection. Such data would help contain its spread and develop preventive and therapeutic antivirals and vaccines. A new preprint that appeared recently on the bioRxiv* server describes the high degree of protection afforded by antibodies that target the N-terminal domain (NTD) of the virus.

24 Dec 2020

Miniature pH probe allows real-time analysis of pH dynamics in deep brain structures

Researchers at Tohoku University have developed the first all-in-one miniature pH probe for real-time investigations of intrinsic extracellular pH dynamics in the deep brain structures.

24 Dec 2020

Researchers use fruit fly model to understand COVID-19-related neurological complications

Researchers claim to have reproduced disease mechanisms due to coronavirus disease 2019 (COVID-19) in the fruit fly, Drosophila, while also providing proof of the efficacy of one drug against these disease processes. If validated, these findings represent a new understanding of how the virus causes neurological symptoms that could help develop more effective therapies.

23 Dec 2020

Phase 2/3 COVID-19 study evaluates safety, potential identification of preliminary efficacy signals

Top-line data from the 270-patient global Phase 2/3 COVID-19 study expected Q1/2021. Top-line data from the 40-patient U.S. Phase 2 study of opaganib in severe COVID-19 expected in the coming days; this non-powered study was designed to evaluate safety and potential identification of preliminary efficacy signals in support of the global Phase 2/3 study of opaganib.

23 Dec 2020

Study reveals innovative gene therapy approach to regenerate functional new neurons

Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. While decades of research have made significant progress in axonal regeneration after SCI, most of the interventions have not been translated into clinical therapies.

18 Dec 2020

in vivo News and Research

Wireless medical device might help with weight loss

Are SARS-CoV-2 antibodies associated with disease enhancement?

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Replacing the RNA strand with DNA may enhance efficacy of ASO-based drugs

Novel imaging method reveals in vivo localization of antibiotics in infected lung tissues

P2 COVID-19 study shows no material safety differences between opaganib and control arms

New device for investigating intrinsic extracellular pH dynamics in the brain

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

Miniature pH probe allows real-time analysis of pH dynamics in deep brain structures

Researchers use fruit fly model to understand COVID-19-related neurological complications

Phase 2/3 COVID-19 study evaluates safety, potential identification of preliminary efficacy signals

Study reveals innovative gene therapy approach to regenerate functional new neurons

SARS-CoV-2 surface proteins alter the expression of key chemokines and cytokines in cell lines

Gene surfing caused the SARS-CoV-2 D614G variant to rise to dominance in the US

Low-intensity pulsed ultrasound combined with microbubbles might enhance chemotherapy delivery

Mogrify solidifies IP position surrounding core technology and expands platform algorithm to enhance cell conversion

Novel method reveals the synaptic basis for feature selectivity

Researchers use bacterial strains to measure host gene expression in mouse model

Researchers focus on preventing infections caused by carbapenemase-producing bacteria

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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