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Researchers engineer antibody that broadly neutralizes a range of clade 1 sarbecoviruses

Researchers have engineered an antibody that neutralizes SARS-CoV-2 with a potency that "rivals" current lead SARS-CoV-2 clinical neutralizing antibodies, and that also broadly neutralizes a range of clade 1 sarbecoviruses.

26 Jan 2021

Study shows link between early brainstem tau accumulation and cortical hyperexcitability

Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the first deposits of tau proteins in the brainstem are associated with neurophysiological processes specific to the early stages of Alzheimer's disease development.

25 Jan 2021

UNSW develops a ceramic-based ink to 3D-print bone parts with living cells

3D printers may one day become a permanent fixture of the operating theatre after UNSW scientists showed they could print bone-like structures containing living cells.

25 Jan 2021

George Mason researchers investigating COVID-19 therapies

Yuntao Wu, Professor, Molecular and Microbiology, and Ramin Hakami, Associate Professor, School of Systems Biology, are conducting studies of COVID-19 therapies.

22 Jan 2021

Pancreatic β cell-derived exosomal miR-29s manipulate glucose homeostasis

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs).

22 Jan 2021

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

A new study by US-based researchers shows the presence of protective antibodies that target the N-terminal domain (NTD) of the spike instead of the spike receptor-binding domain (RBD).

22 Jan 2021

Patient-specific model is needed to understand cancer cells and their impacts

Despite cancer being a leading cause of death worldwide, treatment options for many types of cancers remain limited. This is partly due to the in vitro tools used to model cancers, which cannot adequately predict the behavior of a cancer or its sensitivity to drugs.

22 Jan 2021

Automated method tracks cortical origin and initial spread of TAU proteins in Alzheimer’s disease

Researchers have developed an automated method that can track the development of harmful clumps of TAU protein related to Alzheimer's disease in the brain, according to work involving 443 individuals.

20 Jan 2021

Gene editing shows potential to correct mutations causing inherited retinal degeneration

Gene editing therapies, including CRISPR-Cas systems, offer the potential to correct mutations causing inherited retinal degenerations, a leading cause of blindness.

20 Jan 2021

Researchers develop ultra-small nanomedicines to target intractable cancers

Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.

19 Jan 2021

The structure dynamics of the SARS-CoV-2 genome in cells, cell lysates and virions

Now, a new preprint research paper posted to the bioRxiv server describes the structures observed during the lifecycle of the RNA virus in terms of both canonical and alternative structures, RNA-RNA interactions, and replication regulation.

19 Jan 2021

Inflammation may contribute to the persistence of C. diff infection, shows study

A new study from North Carolina State University shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive.

19 Jan 2021

CoQ10 supplement could be a valuable complementary therapeutic option for various diseases

A study led by scientists from the University of Granada (UGR) has found that a supplement of Coenzyme Q10 (CoQ10), an essential molecule for life that is synthesized in the cells of our organs and tissues and is also acquired through diet, could constitute a valuable complementary therapeutic option in the treatment of certain mitochondrial diseases, colon cancer, thyroid carcinoma, and Crohn’s disease.

18 Jan 2021

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

A new study suggests that modified natural killer cells, which express a chimeric antigen receptor using S309 antibody, can bind to and inactivate SARS-CoV-2 spike protein in vitro.

18 Jan 2021

Angiopoietin-2 is a crucial determinant of COVID-19 prognosis, study finds

A team of scientists from the United States and Sweden has recently demonstrated that increased levels of a proinflammatory cytokine, angiopoietin-2, is responsible for hypercoagulation observed in severe COVID-19 patients.

18 Jan 2021

Researchers design new biosynthetic pathways for short-chain primary amines

Researchers report a new strategy for the microbial production of multiple short-chain primary amines via retrobiosynthesis.

17 Jan 2021

Research suggests St. John's Wort and Echinacea could protect against COVID-19

Researchers in Saudi Arabia have conducted a study demonstrating the antiviral effects of two medicinal herbs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

17 Jan 2021

Researchers show how optoacoustics can be used for monitoring skin water content

Researchers from Skoltech and the University of Texas Medical Branch (US) have shown how optoacoustics can be used for monitoring skin water content, a technique which is promising for medical applications such as tissue trauma management and in cosmetology.

16 Jan 2021

Study reveals significant role of ADAMTS1 protein in uveal melanoma

Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.

15 Jan 2021

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

An encouraging new study describes a promising new therapeutic antibody that shows potent neutralizing activity against SARS-CoV-2, the causative agent of COVID-19.

15 Jan 2021

in vivo News and Research

Researchers engineer antibody that broadly neutralizes a range of clade 1 sarbecoviruses

Study shows link between early brainstem tau accumulation and cortical hyperexcitability

UNSW develops a ceramic-based ink to 3D-print bone parts with living cells

George Mason researchers investigating COVID-19 therapies

Pancreatic β cell-derived exosomal miR-29s manipulate glucose homeostasis

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

Patient-specific model is needed to understand cancer cells and their impacts

Automated method tracks cortical origin and initial spread of TAU proteins in Alzheimer’s disease

Gene editing shows potential to correct mutations causing inherited retinal degeneration

Researchers develop ultra-small nanomedicines to target intractable cancers

The structure dynamics of the SARS-CoV-2 genome in cells, cell lysates and virions

Inflammation may contribute to the persistence of C. diff infection, shows study

CoQ10 supplement could be a valuable complementary therapeutic option for various diseases

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

Angiopoietin-2 is a crucial determinant of COVID-19 prognosis, study finds

Researchers design new biosynthetic pathways for short-chain primary amines

Research suggests St. John's Wort and Echinacea could protect against COVID-19

Researchers show how optoacoustics can be used for monitoring skin water content

Study reveals significant role of ADAMTS1 protein in uveal melanoma

Study reports promising new monoclonal antibody against SARS-CoV-2’s spike protein

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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