Immune System News and Research

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New strategies to fight the most dangerous infectious disease

It has been identified by the World Health Organization as the most dangerous infectious disease, causing more deaths -- more than 2 million a year -- than any other single infection. Approximately one-third of the world's population is already infected.

31 Aug 2005

Carbohydrate known as OGT2378 inhibits tumor growth

A non-toxic chemical compound that prevents cancer cells from producing a critical membrane component has been shown to suppress tumor growth and tumor size in mice without unwanted side effects, according to researchers at the Children’s National Medical Center in Washington, D.C.

30 Aug 2005

Data show that HIV-infected older people not taking HAART have double the risk of death

HIV is often regarded as a disease of young people, due to its status as a drug-related or sexually transmitted disease. However, the number of people over age 50 who are infected with HIV is significant--and growing--according to an article in the Sept. 15 issue of Clinical Infectious Diseases, now available online.

30 Aug 2005

Emergent Biosolutions' typhoid vaccine achieves positive results in Phase II clinical study

Emergent BioSolutions today announced positive results from a Phase II clinical study evaluating a new simplified dosing regimen for the company's next generation single dose oral typhoid vaccine. The results of the study were published in the August edition of the Journal of Infectious Diseases.

30 Aug 2005

Good old fashioned soap and water the answer for "superbug"

Superbugs are bacteria that have mutated to become resistant to common antibiotics which are no longer any use against them.

30 Aug 2005

Dental problems caused by radiation, chemotherapy should be treated before a child undergoes immunosuppression as part of bone marrow transplantation therapy

Many children who undergo bone marrow transplantation (BMT) as part of cancer treatment already have dental abnormalities that leave them vulnerable to potentially life-threatening bacterial infections, according to investigators at St. Jude Children's Research Hospital. A report on this study appears in the prepublication online edition of Bone Marrow Transplantation.

29 Aug 2005

Three-dimensional molecular structure of a promising malaria-vaccine component

An international team of scientists that includes a researcher from the U.S. Department of Energy's Brookhaven National Laboratory has determined the three-dimensional molecular structure of a promising malaria-vaccine component.

29 Aug 2005

Relative of the celebrated COX-2 inhibitor celecoxib is tough tumor fighter

A close structural relative of the celebrated COX-2 inhibitor celecoxib (brand name: Celebrex) is a potent tumor fighter, able to wipe out tumor cells that are resistant to conventional chemotherapies, according to an interdisciplinary team of researchers from the University of Southern California.

29 Aug 2005

Vitamin D puts a brake on activated macrophages - newly discovered mechanism keeps inflammation under control

When macrophages, the first line defender cells of the immune system become activated, they produce an inhibitor, which acts back on them to suppress their activity.

29 Aug 2005

SPF may not be enough to protect against skin cancer

Immune protection factor (IPF) in sunscreens and its relation to sun protection factor (SPF) is essential in determining skin cancer prevention ability, researchers found.

29 Aug 2005

Tuberculosis emergency in Africa

According to the World Health Organisation (WHO), African health ministers have declared a tuberculosis emergency to order to rally greater political commitment in the fight against one of the continent's top killers.

29 Aug 2005

Discovery may significantly advance the treatment of cancers and infectious diseases

Current treatments frequently achieve only limited results with these types of diseases, which affect hundreds of thousands of Canadians.

29 Aug 2005

Study reveals functional link between emotion processing centers in the brain and certain physiological processes relevant to disease

The mere mention of a stressful word like "wheeze" can activate two brain regions in asthmatics during an attack, and this brain activity may be associated with more severe asthma symptoms, according to a study by University of Wisconsin-Madison researchers and collaborators.

29 Aug 2005

Carbohydrate-based vaccine against cancer?

Couldn't we be immunized against cancer? This sounds like a dream, but is in fact a thoroughly realistic research goal. American researchers have now taken an important step forward in the development of a cancer vaccine.

29 Aug 2005

Previously unknown family of plague virulence factors identified

Researchers at Duke University Medical Center have identified a previously unknown family of virulence factors that make the bacterium responsible for the plague especially efficient at killing its host.

28 Aug 2005

Ways to avoid hazards of heart bypass under study

The heart-lung bypass machine that stills the heart while surgeons bypass an adult’s clogged arteries or repair a baby’s malformed heart can also trigger a potentially deadly inflammatory response.

28 Aug 2005

Immunity - another important function of the mitochondria

Researchers have discovered a surprise lurking inside mitochondria, the power plants that are present in every cell. It turns out that these powerhouses also contain a protein that triggers the immune system to attack viral invaders.

28 Aug 2005

Inflammation plays an important role in post-operative stroke

Duke University Medical Center researchers have discovered that patients who have two specific gene variants are more than three times as likely to suffer a stroke after heart surgery.

26 Aug 2005

New strategy to turn off the function of a special group of T cells to suppress immune response to tumors

A special stretch of genetic material may turn off the immune suppression that stymies attempts to fight cancer with a vaccine, said researchers at Baylor College of Medicine (BCM) at Houston.

26 Aug 2005

The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma

Research led by Dr. Anne Mueller at Stanford University School of Medicine demonstrates that successful eradication of Helicobacter may not prevent future aggressive gastric lymphoma since resting B cells are left behind.

25 Aug 2005

Immune System News and Research

New strategies to fight the most dangerous infectious disease

Carbohydrate known as OGT2378 inhibits tumor growth

Data show that HIV-infected older people not taking HAART have double the risk of death

Emergent Biosolutions' typhoid vaccine achieves positive results in Phase II clinical study

Good old fashioned soap and water the answer for "superbug"

Dental problems caused by radiation, chemotherapy should be treated before a child undergoes immunosuppression as part of bone marrow transplantation therapy

Three-dimensional molecular structure of a promising malaria-vaccine component

Relative of the celebrated COX-2 inhibitor celecoxib is tough tumor fighter

Vitamin D puts a brake on activated macrophages - newly discovered mechanism keeps inflammation under control

SPF may not be enough to protect against skin cancer

Tuberculosis emergency in Africa

Discovery may significantly advance the treatment of cancers and infectious diseases

Study reveals functional link between emotion processing centers in the brain and certain physiological processes relevant to disease

Carbohydrate-based vaccine against cancer?

Previously unknown family of plague virulence factors identified

Ways to avoid hazards of heart bypass under study

Immunity - another important function of the mitochondria

Inflammation plays an important role in post-operative stroke

New strategy to turn off the function of a special group of T cells to suppress immune response to tumors

The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma

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