Animal Model News and Research

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Discovery of gene associated with epilepsy

A University of Iowa-led international research team has found a new gene associated with the brain disorder epilepsy.

18 Nov 2008

Cigarette smoke may reshape the left ventricle

Prolonged exposure to cigarette smoke can increase levels of the stress hormone norepinephrine and enzymes in the heart that have the potential to reshape the left ventricle, according to new research at the University of Illinois at Chicago.

16 Nov 2008

Discovery of mechanism that regulates the development of stem cells into neurons

Researchers at the University of Southern California (USC) have identified a novel mechanism in the regulation and differentiation of neural stem cells.

11 Nov 2008

Signaling between protein, growth factor is critical for coordinated cell migration

The mysterious process that orchestrates cells to move in unison to form human and animal embryos, heal wounds, and even spread cancer depends on interaction between two well-known genetic signaling pathways, two University of Utah medical school researchers have discovered.

11 Nov 2008

Researchers aim to over-stress already taxed mantle cell lymphoma cells

Cancer cells are already stressed by the fast pace they require to grow and spread and scientists believe a little more stress just may kill them.

11 Nov 2008

T-cell-based strategy for HIV-1 vaccines still viable option

The question of whether or not to continue to pursue the development of T-cell-based HIV-1 vaccines has been a source of controversy following last year's widely publicized failure of the field's most promising candidate, a vaccine developed by Merck known as V520.

10 Nov 2008

Respiratory syncytial virus may hide in the lungs, lead to asthma

Conventional wisdom has been that respiratory syncytial virus (RSV) - a common virus that causes infection in the lungs - comes and goes in children without any long lasting impact.

27 Oct 2008

High-dose hormone treatment might reduce risk for posttraumatic stress disorder

Cortisol helps our bodies cope with stress, but what about its effects on the brain? A new study by Cohen and colleagues, appearing in the October 15th issue of Biological Psychiatry, suggests that the answer to this question is complex.

22 Oct 2008

Brain-derived neurotrophic factor may predict schizophrenia relapse

A factor that helps optimize brain formation and function may also provide clues about whether patients suffering with schizophrenia are headed toward relapse, researchers say.

16 Oct 2008

New pig model of cystic fibrosis provides better understanding of human disease

For the first time, researchers have developed a genetically altered animal model for cystic fibrosis (CF) that closely matches the characteristics of the disease in humans. By studying the complex and multi-organ disease process in the pig model, researchers can now better understand how the complications of CF develop, an advancement that may lead to new avenues for research in prevention and treatment.

25 Sep 2008

The underdevelopment of a specific brain region may cause schizophrenia

The underdevelopment of a specific region in the brain may lead to schizophrenia in individuals. According to research published today in BioMed Central's open access journal Molecular Brain, dentate gyrus, which is located in the hippocampus in the brain and thought to be responsible for working memory and mood regulation, remained immature in an animal model of schizophrenia.

10 Sep 2008

Killing bacteria isn't enough to restore immune function after infection, researchers find

A bacterial molecule that initially signals to animals that they have been invaded must be wiped out by a special enzyme before an infected animal can regain full health, researchers at UT Southwestern Medical Center have found.

10 Sep 2008

Berries show to have a genome-wide effect on the expression of genes involved in cancer development

New research strongly suggests that a mix of preventative agents, such as those found in concentrated black raspberries, may more effectively inhibit cancer development than single agents aimed at shutting down a particular gene.

27 Aug 2008

Blood pressure response to daily stress provides clues for better hypertension treatment

How the body regulates blood pressure in response to daily stress is the focus of a study geared toward helping people whose pressure is out of control.

14 Aug 2008

Researchers identify molecular mechanism underlying a genetic brain malformation called holoprosencephaly

St. Jude Children's Research Hospital scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE).

11 Aug 2008

Dopamine and Parkinson's

Parkinson's disease and drug addiction are polar opposite diseases, but both depend upon dopamine in the brain. Parkinson's patients don't have enough of it; drug addicts get too much of it. Although the importance of dopamine in these disorders has been well known, the way it works has been a mystery.

10 Aug 2008

RNAi used to dramatically suppress HIV infection in an organism

Hopes languished last September when a promising candidate HIV vaccine failed to work. Despite this setback, many researchers still believe immunization is possible, and a new study suggests they're correct-at least at the cellular level.

10 Aug 2008

Study sheds light on why addiction is a chronic disease

Drug addiction dramatically shifts a person's attention, priorities, and behaviors towards a focus almost entirely on seeking out and taking drugs. Now, an animal study funded by the National Institute on Drug Abuse, part of the National Institutes of Health, has identified some of the specific long-term adaptations in the brain's reward system that may contribute to this shift.

31 Jul 2008

Bladder problems may leave mark on brain contributing to sleep and attention problems

Bladder problems may leave a mark on the brain, by changing patterns of brain activity, possibly contributing to disrupted sleep and problems with attention. For one in six Americans who have overactive bladder, the involuntary bladder contractions that often trigger more frequent urges to urinate, such mind-body connections may be of more than academic interest.

29 Jul 2008

Breakthrough in crippling childhood disease Friedreich's ataxia

University of Sydney scientists have made a breakthrough that could lead to new treatments for the crippling childhood disease Friedreich's ataxia.

28 Jul 2008

Animal Model News and Research

Discovery of gene associated with epilepsy

Cigarette smoke may reshape the left ventricle

Discovery of mechanism that regulates the development of stem cells into neurons

Signaling between protein, growth factor is critical for coordinated cell migration

Researchers aim to over-stress already taxed mantle cell lymphoma cells

T-cell-based strategy for HIV-1 vaccines still viable option

Respiratory syncytial virus may hide in the lungs, lead to asthma

High-dose hormone treatment might reduce risk for posttraumatic stress disorder

Brain-derived neurotrophic factor may predict schizophrenia relapse

New pig model of cystic fibrosis provides better understanding of human disease

The underdevelopment of a specific brain region may cause schizophrenia

Killing bacteria isn't enough to restore immune function after infection, researchers find

Berries show to have a genome-wide effect on the expression of genes involved in cancer development

Blood pressure response to daily stress provides clues for better hypertension treatment

Researchers identify molecular mechanism underlying a genetic brain malformation called holoprosencephaly

Dopamine and Parkinson's

RNAi used to dramatically suppress HIV infection in an organism

Study sheds light on why addiction is a chronic disease

Bladder problems may leave mark on brain contributing to sleep and attention problems

Breakthrough in crippling childhood disease Friedreich's ataxia

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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