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New super-resolution microscopy method could spot dozens of distinct types of biomolecules

A new microscopy method could enable scientists to generate snapshots of dozens of different biomolecules at once in a single human cell, a team from the Wyss Institute of Biologically Inspired Engineering at Harvard University reported Sunday in Nature Methods.

4 Feb 2014

Innovation Center's methods under the microscope

The idea seemed transformative. The Affordable Care Act would fund a new research outfit evocatively named the Innovation Center to discover how to most effectively deliver health care, with $10 billion to spend over a decade.

4 Feb 2014

IDH1 gene mutation determines best treatment for malignant astrocytomas

Astrocytomas are the most common malignant brain tumors. While most patients' tumors prove to be quite aggressive, outcomes overall can vary widely, with some patients surviving for many years.

4 Feb 2014

Protein study opens new avenue for cancer researchers

One of the hopes for victory against cancer hinges on naturally-occurring proteins whose job is to make their host cell die. Since their natural role is to stop unhealthy cell proliferation, the idea is that one or more of these proteins could be harnessed to stop the growth of tumors.

3 Feb 2014

Researchers gain better understanding of HIV infection through electron microscopy

The human intestinal tract, or gut, is best known for its role in digestion. But this collection of organs also plays a prominent role in the immune system. In fact, it is one of the first parts of the body that is attacked in the early stages of an HIV infection. Knowing how the virus infects cells and accumulates in this area is critical to developing new therapies for the over 33 million people worldwide living with HIV. Researchers at the California Institute of Technology are the first to have utilized high-resolution electron microscopy to look at HIV infection within the actual tissue of an infected organism, providing perhaps the most detailed characterization yet of HIV infection in the gut.

30 Jan 2014

New technique enables visualisation of human autoimmune disease in animal models

Researchers at Lund University have managed to develop a technique whereby they can study the inflammatory process that takes place in the pancreas during the natural development of type 1 diabetes, allowing for real time and repeated non-invasive imaging of individual islets of Langerhans.

29 Jan 2014

Phasefocus reports on new ptychography paper published in Nature Scientific Reports

Cell imaging often relies on synthetic or genetic fluorescent labels, to provide contrast which can be far from ideal for imaging cells in their in vivo state. We report on the biological application of a label-free, high contrast microscopy technique known as ptychography, in which the image producing step is transferred from the microscope lens to a high-speed phase retrieval algorithm.

From Phase Focus Limited 28 Jan 2014

Researchers detect cancer cells using olfactory senses of fruit flies

A research unit in an international cooperation project, led by the Konstanz-based neurobiologist and zoologist Professor Dr. Giovanni Galizia, has been the first to demonstrate that fruit flies are able to distinguish cancer cells from healthy cells via their olfactory sense.

25 Jan 2014

Interplanetary dust particles could deliver water and organics to the Earth, say scientists

Researchers from the University of Hawaii - Manoa (UHM) School of Ocean and Earth Science and Technology (SOEST), Lawrence Livermore National Laboratory, Lawrence Berkeley National Laboratory, and University of California - Berkeley discovered that interplanetary dust particles (IDPs) could deliver water and organics to the Earth and other terrestrial planets.

25 Jan 2014

New techniques simplify current test procedures for developing new medications

When developing new medications, biologists and pharma- cologists test different active ingredients and chemical compounds. The main purpose is to find out how biological cells react to these substances.

24 Jan 2014

Statistical methods improve biological single-cell analyses

Each cell in our body is unique. Even cells of the same tissue type that look identical under the microscope differ slightly from each other.

24 Jan 2014

New technique detects bacterium that causes Legionnaires’ disease

The bacterium that causes Legionnaires’ disease remains difficult to track. French researchers have now developed a new technique that should allow living representatives of this dangerous pathogen to be detected much more quickly than with conventional methods. As they report in the journal Angewandte Chemie, samples are exposed to an azide-modified compound that the pathogen specifically incorporates into its shell, which is made of saccharide units. A fluorescent marker attached to the azide groups is used to identify the pathogen.

24 Jan 2014

New discovery provides insight into body's rejection process during transplantation

In 2009, the first face transplant was performed at Brigham and Women's Hospital (BWH), and lead surgeon, Dr. Bohdan Pomahac has been pioneering the procedure since.

20 Jan 2014

Longer reads: Connecting with patients; obesity origins; children with chronic disease

I'd never [before] been encouraged to sit at a patient's bedside - to stop hurrying for even a moment. Our medical teachers put a premium on accuracy and efficiency, which became conflated with speed.

17 Jan 2014

Questions surround future of some troubled state exchanges

State insurance exchanges in Maryland, Oregon and Colorado are under the microscope and drawing criticism. Meanwhile, Republican state lawmakers in Tennessee and Texas propose legislation to undermine the health law in those states. And a cybersecurity official at the Department of Health and Human Services tells congressional investigators that testing of healthcare.gov, the federal online exchange, was inadequate.

16 Jan 2014

Researchers develop personalized tool to predict likelihood of prostate cancer overdiagnosis

Studies have found that prostate cancer is overdiagnosed in up to 42 percent of cases, prompting men to receive unnecessary treatment that can cause devastating side effects, including impotence and incontinence.

9 Jan 2014

Researcher reveals how temperature impacts development of embryos

In nature, animals face a broad range of temperatures, and at times the heat can become taxing. When it becomes too hot to survive, some animals can simply migrate to more favorable climates, but what if you are a mere embryo confined within an egg and cannot escape the heat?

6 Jan 2014

Researchers observe mating for the first time in microbes responsible for African sleeping sickness

Caught in the act! Researchers from the University of Bristol have observed mating for the first time in the microbes responsible for African sleeping sickness. This tropical disease is caused by trypanosomes, single-celled parasites that are found in the blood of those afflicted.

5 Jan 2014

Innovation leads to faster drug therapies, increased understanding of proteins on microscopic level

Membrane proteins are the "gatekeepers" that allow information and molecules to pass into and out of a cell. Until recently, the microscopic study of these complex proteins has been restricted due to limitations of "force microscopes" that are available to researchers and the one-dimensional results these microscopes reveal.

17 Dec 2013

New Opterra multipoint scanning confocal microscope from Bruker

Today at the 2013 American Society for Cell Biology Annual Meeting, Bruker introduced the Opterra Multipoint Scanning Confocal Microscope, which sets a new standard for integration of confocal imaging with photoactivation.

16 Dec 2013

Microscope News and Research

New super-resolution microscopy method could spot dozens of distinct types of biomolecules

Innovation Center's methods under the microscope

IDH1 gene mutation determines best treatment for malignant astrocytomas

Protein study opens new avenue for cancer researchers

Researchers gain better understanding of HIV infection through electron microscopy

New technique enables visualisation of human autoimmune disease in animal models

Phasefocus reports on new ptychography paper published in Nature Scientific Reports

Researchers detect cancer cells using olfactory senses of fruit flies

Interplanetary dust particles could deliver water and organics to the Earth, say scientists

New techniques simplify current test procedures for developing new medications

Statistical methods improve biological single-cell analyses

New technique detects bacterium that causes Legionnaires’ disease

New discovery provides insight into body's rejection process during transplantation

Longer reads: Connecting with patients; obesity origins; children with chronic disease

Questions surround future of some troubled state exchanges

Researchers develop personalized tool to predict likelihood of prostate cancer overdiagnosis

Researcher reveals how temperature impacts development of embryos

Researchers observe mating for the first time in microbes responsible for African sleeping sickness

Innovation leads to faster drug therapies, increased understanding of proteins on microscopic level

New Opterra multipoint scanning confocal microscope from Bruker

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