Preclinical News and Research

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Study provides new insights into how cannabis extracts may work to treat epilepsy

Research from pharmacologists at the University of Sydney provides new insights into how cannabis extracts may work to treat epilepsy.

6 Oct 2021

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

MUSC Hollings Cancer Center researcher Haizhen (Jen) Wang, Ph.D., was awarded a five-year $344,000 per year grant by the National Cancer Institute to pursue her early investigator studies in leukemia.

5 Oct 2021

Cancer drug can restore memory and cognitive function in mice with Alzheimer’s symptoms

A drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's disease, new UBC research has found.

5 Oct 2021

Plant-derived compound can be beneficial in protecting the brain against Alzheimer’s disease pathology

Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer's disease pathology, a preclinical study led by University of South Florida Health (USF Health) researchers suggests.

5 Oct 2021

Study highlights sex differences in the brain biology that controls alcohol drinking behaviors

A brain circuit that works as a "brake" on binge alcohol drinking may help explain male-female differences invulnerability to alcohol use disorders, according to a preclinical study led by scientists at Weill Cornell Medicine.

5 Oct 2021

Experimental vaccine shows significant promise in preventing rheumatoid arthritis

Researchers at The University of Toledo have developed an experimental vaccine that shows significant promise in preventing rheumatoid arthritis, a painful autoimmune disease that cannot currently be cured.

4 Oct 2021

Antiviral activity of wheat germ Agglutinin against SARS-CoV-2

A new study reports the antiviral activity of WGA against SARS-CoV-2 and its two Variants of Concern - Alpha and Beta.

4 Oct 2021

Novel Assay Platform for 3D Microfluidic Cancer Research

AMSBIO have supplied custom Chimeric antigen receptor (CAR)-T products to the University of Strathclyde (UoS) in Glasgow, UK, and ScreenIn3D Ltd, allowing them to perform novel immune-oncology assays in 3D microfluidic cancer models.

From AMS Biotechnology 1 Oct 2021

A call to action for reducing health disparities and advancing treatments for Parkinson's patients

Current knowledge about Parkinson's disease (PD) does not reflect the diversity of people with the disease, according to The Michael J. Fox Foundation for Parkinson's Research (MJFF).

1 Oct 2021

New SBIR award helps Temple scientists to explore the therapeutic potential of novel cannabis analog

More than 20 percent of adults in the United States live with chronic pain. For many affected individuals, long-term physical discomfort negatively impacts overall well-being, leading to reduced work output and increased anxiety and depression.

29 Sep 2021

Research points to new opportunities to prevent treatment resistance in fragile X syndrome

Mark Bear, Picower Professor of Neuroscience at MIT, recalls the "eureka moment" 20 years ago when he realized that a severe developmental brain disorder - fragile X syndrome - might be treated with drugs that inhibit a neurotransmitter receptor called mGluR5.

29 Sep 2021

New 'priming' approach may improve the efficacy of chemotherapy for pancreatic cancer

A new approach to 'prime' the tumor environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Combination of two drugs may help pancreatic and liver cancer patients

A drug candidate discovered and developed decades ago in the laboratory of UC Davis distinguished professor Bruce Hammock may help control the body's raging and often deadly inflammatory response to chemotherapy treatments, especially for pancreatic and liver cancer patients.

29 Sep 2021

UNLV neuroscientists bolster the connection between Type II diabetes and Alzheimer's disease

A team of UNLV neuroscientists has strengthened the link between Type II diabetes and Alzheimer's disease.

28 Sep 2021

NIAID awards approximately $36.3 million to fuel vaccine research for coronaviruses

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded approximately $36.3 million to three academic institutions to conduct research to develop vaccines to protect against multiple types of coronaviruses and viral variants.

28 Sep 2021

New study clears a pharmacologic hurdle in developing molecularly targeted therapies for AML

New research from Johns Hopkins Kimmel Cancer Center investigators shows why some drugs in clinical trials for treating a form of acute myeloid leukemia (AML) often fail and demonstrates a way to restore their effectiveness.

27 Sep 2021

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Twist Bioscience Corporation (Nasdaq: TWST) today reported that its internally-discovered antibody candidate TB202-3 (CoVIC-094), demonstrated potent binding to diverse SARS-CoV-2 variant mutations, including strains with the E484K, N501Y, D614G, Y453F and K417N mutations in pseudovirus assays, indicating this therapeutic antibody may be effective in treating many strains of COVID-19.

25 Sep 2021

Small molecule drug can attenuate the triggers of neuroinflammation, preclinical study shows

Neuroinflammation can worsen outcomes in stroke, traumatic brain injury, or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson's, or Alzheimer's. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that are driven by neuroinflammation.

24 Sep 2021

A daily pill to treat covid could be just months away, scientists say

Within a day of testing positive for covid-19 in June, Miranda Kelly was sick enough to be scared. At 44, with diabetes and high blood pressure, Kelly, a certified nursing assistant, was having trouble breathing, symptoms serious enough to send her to the emergency room.

24 Sep 2021

Preclinical News and Research

Study provides new insights into how cannabis extracts may work to treat epilepsy

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

Cancer drug can restore memory and cognitive function in mice with Alzheimer’s symptoms

Plant-derived compound can be beneficial in protecting the brain against Alzheimer’s disease pathology

Study highlights sex differences in the brain biology that controls alcohol drinking behaviors

Experimental vaccine shows significant promise in preventing rheumatoid arthritis

Antiviral activity of wheat germ Agglutinin against SARS-CoV-2

Novel Assay Platform for 3D Microfluidic Cancer Research

A call to action for reducing health disparities and advancing treatments for Parkinson's patients

New SBIR award helps Temple scientists to explore the therapeutic potential of novel cannabis analog

Research points to new opportunities to prevent treatment resistance in fragile X syndrome

New 'priming' approach may improve the efficacy of chemotherapy for pancreatic cancer

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Combination of two drugs may help pancreatic and liver cancer patients

UNLV neuroscientists bolster the connection between Type II diabetes and Alzheimer's disease

NIAID awards approximately $36.3 million to fuel vaccine research for coronaviruses

New study clears a pharmacologic hurdle in developing molecularly targeted therapies for AML

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Small molecule drug can attenuate the triggers of neuroinflammation, preclinical study shows

A daily pill to treat covid could be just months away, scientists say

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