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Collegium Pharmaceutical receives USPTO notice of allowance for novel formulation of milnacipran

Collegium Pharmaceutical, Inc., a specialty pharmaceutical company, announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office (USPTO) for its patent application "Modified Release Compositions of Milnacipran", US Patent Application Number 12/211,780. The Notice of Allowance is the USPTO's official communication that the Company's application has successfully completed examination and that a patent will be issued.

31 Mar 2010

LSUHSC: Differences in drug metabolism can lead to differences in the effectiveness of candidate drug

Research led by Wayne L. Backes, PhD, Professor of Pharmacology and Associate Dean for Research at LSU Health Sciences Center New Orleans School of Medicine, has found that drug metabolism depends not only upon which enzymes are present in an individual, but also how they interact, and that can be the difference in whether a drug is safely eliminated from the body or is converted into a toxic or carcinogenic byproduct.

18 Mar 2010

BIOCRATES Life Sciences, CHENOMX announce co-marketing agreement

Austrian biomarker developer BIOCRATES Life Sciences AG announced today that it entered a co-marketing agreement with Canadian-based CHENOMX Inc. Both enterprises focus on a new and highly promising technology aimed at generating a metabolic profile of the human organism that can be used to monitor the effects of disease, nutrition, toxins, environment, or drugs on an organism.

10 Mar 2010

Research reveals maple syrup and maple water contain abscisic acid

Thanks to modern science, the closely guarded secrets of one of our nation's most distinctive emblems, maple syrup, are now being revealed. It has recently been reported that maple syrup contains polyphenols and shows ORAC values which compare to commonly eaten fruits and vegetables such as broccoli.

5 Mar 2010

AB SCIEX collaborates with Mass Spectrometry Centre to improve drug discovery and development

AB SCIEX, a global leader in life science analytical technologies, today announced that it is collaborating with the University of Geneva’s Mass Spectrometry Centre to create new workflows and analytical strategies intended to significantly improve drug discovery and development.

4 Mar 2010

New dietary supplement blocks triggering mechanism causing breast cell mutations

Every 13 minutes a woman loses her battle with breast cancer and in 2009 alone more than 27,000 men died from prostate cancer. These powerful statistics continue to fuel research and new developments. With tens of millions of dollars in financial support from the National Cancer Institute and the U.S. Department of Defense, scientists have identified when estrogen metabolism is out of balance it can start the process leading to breast cell mutations.

26 Feb 2010

Chiltern International and Charles River Laboratories to study radiolabelled drug products

Chiltern International Limited, a global contract research organization (CRO), announced its latest collaboration with Charles River Laboratories, Inc. As part of this collaboration, Chiltern Early Phase will partner with Charles River to conduct and support early phase radiolabelled studies.

22 Feb 2010

Researchers identify specific metabolic profiles that predict risk of heart attack and death

Tiny bits of molecular "trash" found in circulating blood appear to be good predictors of cardiovascular disease and untimely death, say researchers at Duke University Medical Center.

19 Feb 2010

Unusual compounds in pitcher plant could prove effective against human fungal infections

The moment insects like flies, ants and beetles fall into a pitcher, the plant's enzymes are activated and begin dissolving their new meal, obtaining nutrients such as carbon and nitrogen which are difficult to extract from certain soils.

19 Feb 2010

Researchers find gene mutations that may provide clues for treating AML patients

Although leukemia is one of the best studied cancers, the cause of some types is still poorly understood. Now, a newly found mutation in acute myeloid leukemia patients could account for half of the remaining cases of adult acute leukemia with an unknown origin.

19 Feb 2010

Protein crucial in mediating anti-inflammatory actions of nuclear lipid receptors discovered

Researchers at the Swedish medical university Karolinska Institutet have discovered a protein that is crucial in mediating the anti-inflammatory actions of nuclear lipid receptors. The findings, published in the research journal Genes & Development, link lipid metabolism and inflammation and open up new possibilities for developing treatments of metabolic diseases associated with inflammation, such as diabetes and atherosclerosis.

17 Feb 2010

RI-MUHC and McGill University teams receive $5M CIHR grant for environmental and reproductive health studies

Two teams from the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University received significant support from the Canadian Institutes of Health Research (CIHR) amounting to $5 million over five years.

15 Feb 2010

New project to unravel secret lives of cancer cells may help produce new cancer therapies

A team of scientists from Princeton University and The Cancer Institute of New Jersey has embarked on a major new project to unravel the secret lives of cancer cells that go dormant and self-cannibalize to survive periods of stress. The work may help produce new cancer therapies to stem changes that render cancer cells dangerous and resistant to treatment.

12 Feb 2010

QR Pharma commences clinical trial of Posiphen in early stage AD patients

QR Pharma, Inc. , a developer of novel drugs to treat Alzheimer’s disease, announced today that it began a clinical trial of its lead compound, Posiphen, in early stage AD patients.

10 Feb 2010

Nutrient mix shows potential to improve memory in Alzheimer's patients

In the early stages of Alzheimer's disease, patients typically suffer a major loss of the brain connections necessary for memory and information processing. Now, a combination of nutrients that was developed at MIT has shown the potential to improve memory in Alzheimer's patients by stimulating growth of new brain connections.

7 Jan 2010

Scientists identify new gene variants associated with disturbances in lipid metabolism

Scientists of Helmholtz Zentrum München led by Professor Karsten Suhre have identified new gene variants associated with disturbances in the lipid metabolism.

28 Dec 2009

High prevalence of type 2 diabetes may be linked to excess niacin intake

Facing the increasing prevalence of type 2 diabetes worldwide in the past few decades, one may ask what is wrong with humans. Geneticists tell us that the human genome has not changed markedly in such a short time.

23 Dec 2009

Winner of the 2010 Avanti Award in Lipids

The 2010 Avanti Award in Lipids, which recognizes outstanding research contributions in the area of lipid research, has been awarded to David W. Russell, the Eugene McDermott distinguished chair of molecular genetics at the University of Texas Southwestern Medical Center at Dallas.

11 Dec 2009

Patients' urine may provide rapid diagnosis of pneumonia

Doctors may soon be able to quickly and accurately diagnose the cause of pneumonia-like symptoms by examining the chemicals found in a patient's urine, suggests a new study led by UC Davis biochemist Carolyn Slupsky.

10 Dec 2009

Scientists discover the potential basis for urine test to diagnose CAP

Scientists are reporting a discovery of the potential basis for a urine test to diagnose community-acquired pneumonia (CAP), a difficult-to-diagnose disease that is the sixth leading cause of death in the United States.

10 Dec 2009

Metabolites News and Research

Collegium Pharmaceutical receives USPTO notice of allowance for novel formulation of milnacipran

LSUHSC: Differences in drug metabolism can lead to differences in the effectiveness of candidate drug

BIOCRATES Life Sciences, CHENOMX announce co-marketing agreement

Research reveals maple syrup and maple water contain abscisic acid

AB SCIEX collaborates with Mass Spectrometry Centre to improve drug discovery and development

New dietary supplement blocks triggering mechanism causing breast cell mutations

Chiltern International and Charles River Laboratories to study radiolabelled drug products

Researchers identify specific metabolic profiles that predict risk of heart attack and death

Unusual compounds in pitcher plant could prove effective against human fungal infections

Researchers find gene mutations that may provide clues for treating AML patients

Protein crucial in mediating anti-inflammatory actions of nuclear lipid receptors discovered

RI-MUHC and McGill University teams receive $5M CIHR grant for environmental and reproductive health studies

New project to unravel secret lives of cancer cells may help produce new cancer therapies

QR Pharma commences clinical trial of Posiphen in early stage AD patients

Nutrient mix shows potential to improve memory in Alzheimer's patients

Scientists identify new gene variants associated with disturbances in lipid metabolism

High prevalence of type 2 diabetes may be linked to excess niacin intake

Winner of the 2010 Avanti Award in Lipids

Patients' urine may provide rapid diagnosis of pneumonia

Scientists discover the potential basis for urine test to diagnose CAP

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