Antigen News and Research

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Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

The Italian authors of this paper, published in the journal Viruses, have taken this hypothesis and expanded it to include viral particles suspended in the air or on inanimate objects as a possible source of T cell immunity due to the repeated low-dose exposure, potentially explaining virus immunity found in non-infected individuals.

7 Jun 2021

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

A new study by researchers at the Oregon Health & Science University (OHSU) in the USA goes far in answering this question by showing the presence of memory B cells that react to the original SARS-CoV-2 as well as VOCs.

7 Jun 2021

Accuracy of three COVID-sniffing dogs exceeds 85%

A team of scientists from Italy and Brazil has recently conducted a training program for sniffer dogs to detect coronavirus disease 2019 (COVID-19). They have trained the dogs to accurately sense COVID-19 specific volatile organic compounds in sweat samples collected from COVID-19 patients. The study is currently available on the medRxiv* preprint server.

7 Jun 2021

Standardizable assay detects T cell responses to SARS-CoV-2 infection

Researchers in the UK have developed a high-throughput standardizable assay that accurately detects T cell responses to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

6 Jun 2021

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

An interesting new bioRxiv* preprint reports the suppression of monocyte glycolysis and cytokine production when exposed to the virus, following pretreatment with the commonly used drug, metformin.

6 Jun 2021

New treatment option offers disease control and extends life in patients with advanced prostate cancer

Cancer researchers say they have established a new, life-extending treatment option for men with prostate cancer that has spread and become resistant to hormone therapy.

5 Jun 2021

Gene offers some level of protection from severe Covid

The first evidence of a genetic link explaining why some people who catch Covid-19 don't become sick has been discovered.

5 Jun 2021

Maternal SARS-CoV-2 infection imprints immune response in the newborn

A new bioRxiv* preprint reports the immunological footprint in the newborn left by maternal infection with SARS-CoV-2 during pregnancy.

4 Jun 2021

Mast cell activation may underlie inflammation in severe COVID-19

A new preprint research paper posted to the medRxiv* server points to mast cells as major culprits in the etiology of severe and critical COVID-19. This could suggest suitable therapeutic and preventive interventions to reduce the morbidity and mortality of this viral illness.

3 Jun 2021

UC San Diego Health offers new immunotherapy treatment for multiple myeloma following FDA approval

Following the Food and Drug Administration's approval, UC San Diego Health is the first designated medical center in San Diego certified to offer a new immunotherapy treatment of multiple myeloma outside of a clinical trial.

3 Jun 2021

New study will help design better antibodies for potential treatments

Scientists are harnessing hard X-rays in the fight against cancer. A team of researchers, in conjunction with the U.S. Department of Energy's (DOE) Argonne National Laboratory, has used ultrabright X-ray light to determine how specific types of antibodies can tell the difference between different forms of a cancer-linked molecule.

3 Jun 2021

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

A new medRxiv* preprint reports the immunomodulatory effect of the E484K mutation newly acquired by the United Kingdom (U.K.) variant.

2 Jun 2021

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

A new bioRxiv* preprint reports on the successful use of a protocol to expand SARS-CoV-2-reactive T-cells a thousand-fold.

2 Jun 2021

Gauging the efficacy and ease of use of at-home COVID-19 tests

As the country gets vaccinated and begins to re-open, testing remains a key element of safe interactions. Rapid testing for COVID-19 has become more common and accessible, including over-the-counter (OTC) tests approved by the U.S. Food and Drug Administration.

2 Jun 2021

New vaccine candidate with RBD and N protein targets protects against SARS-CoV-2 in preclinical trials

A recent study published in the journal Science Advances, explores the immunization of RBD with the P2 epitope of tetanus toxoid, to enhance its immunogenicity, and also tests the benefit of N protein in the vaccine.

2 Jun 2021

How antibody production in the lungs can determine severe respiratory infections

Recent findings describe how the presence of certain antibodies within the lungs can induce an immune response to minimize the effects of these infections.

2 Jun 2021

Depleting SIRPα-deficient in macrophages activate tumor antigen-specific cytotoxic T cells

In a study that will be published in Nature Communications on May 28, 2021, a research team led by Dr. Yuan Liu from Georgia State University reports that intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells to eliminate various syngeneic cancers under radiotherapy.

2 Jun 2021

Novel antibody engineering approach

Scientists from the Johns Hopkins University School of Medicine, USA, have recently developed an Antibody Display technology by grafting the second extracellular domain of tetraspanin12 (Tspan12EC2) and the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein on the heavy chain complementarity-determining region 3 (CDR3).

2 Jun 2021

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Besides common symptoms such as fever, cough and respiratory distress, some children have an atypical form of COVID-19 known as multisystem inflammatory syndrome in children (MIS-C), characterized by persistent fever and inflammation of several organs, such as the heart and intestines, as well as the lungs to a lesser extent.

1 Jun 2021

SWOG researchers to present practice-changing research at virtual ASCO 2021

"SWOG always brings an impressive portfolio of work to the ASCO annual meeting," said SWOG Chair Charles D. Blanke, MD, "and this year I'm particularly excited about the research our investigators are presenting because it includes results that are likely to be practice-changing."

1 Jun 2021

Antigen News and Research

Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

Accuracy of three COVID-sniffing dogs exceeds 85%

Standardizable assay detects T cell responses to SARS-CoV-2 infection

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

New treatment option offers disease control and extends life in patients with advanced prostate cancer

Gene offers some level of protection from severe Covid

Maternal SARS-CoV-2 infection imprints immune response in the newborn

Mast cell activation may underlie inflammation in severe COVID-19

UC San Diego Health offers new immunotherapy treatment for multiple myeloma following FDA approval

New study will help design better antibodies for potential treatments

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

Gauging the efficacy and ease of use of at-home COVID-19 tests

New vaccine candidate with RBD and N protein targets protects against SARS-CoV-2 in preclinical trials

How antibody production in the lungs can determine severe respiratory infections

Depleting SIRPα-deficient in macrophages activate tumor antigen-specific cytotoxic T cells

Novel antibody engineering approach

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

SWOG researchers to present practice-changing research at virtual ASCO 2021

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