Clinical Trial News and Research

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Researchers identify mechanism that causes gastrointestinal problems with cancer immunotherapy

Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment.

5 Jan 2024

Migraine symptoms linked to retinal blood flow changes

A recent study found changes in blood flow in the retina could explain why some migraine patients experience visual symptoms.

5 Jan 2024

Stapled lipopeptides show promise as broad-spectrum antiviral agents

Compounds that obstruct the "landing gear" of a range of harmful viruses can successfully protect against infection by the virus that causes COVID-19, a study published today and led by Dana-Farber Cancer Institute scientists shows.

5 Jan 2024

Psychedelic drug offers lifesaving relief for veterans plagued by traumatic brain injury

For military veterans, many of the deepest wounds of war are invisible: Traumatic brain injuries resulting from head trauma or blast explosions are a leading cause of post-traumatic stress disorder, anxiety, depression and suicide among veterans.

5 Jan 2024

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

A detailed 'atlas' of neuroblastoma tumors points to a new target for immunotherapy. Scientists from the Princess Máxima Center for Pediatric Oncology in the Netherlands mapped this childhood tumor at the level of individual cancer and immune cells.

4 Jan 2024

Stanford Medicine researchers demonstrate new way to temporarily heighten hypnotizablity

How deeply someone can be hypnotized - known as hypnotizability - appears to be a stable trait that changes little throughout adulthood, much like personality and IQ.

4 Jan 2024

PharmaKure granted MHRA Clinical Trial Authorisation (CTA) for PK051 for the treatment of mild cognitive impairment due to Alzheimer’s Disease

Clinical Trial Authorisation application granted for combined drug PK051 targeting amyloid deposits associated with Alzheimer’s Disease.

From PharmaKure 4 Jan 2024

Sugar showdown: Which sweetener impacts insulin sensitivity the most?

The effects of four types of sweeteners on insulin sensitivity in young adults.

4 Jan 2024

Rare immune cell holds key to predicting melanoma treatment success

A type of immune cell can help predict which patients may benefit most from cancer immunotherapies, researchers from King's College London, Guy's and St Thomas' Hospital Trust, and the Francis Crick Institute have found.

3 Jan 2024

$4.9 million grant awarded to build EndO-trial consortium for improving the lives of Crohn's patients

Cleveland Clinic and the University of Western Ontario have been awarded a $4.9 million grant from Helmsley Charitable Trust to build a consortium to develop clinical trial outcome tools for patients with Crohn's disease and permanent ileostomy.

3 Jan 2024

Existing beta blocker investigated as novel sickle cell therapy

A beta blocker typically used to treat heart problems, hemangioma, migraines and anxiety could be a new therapeutic for patients with sickle cell disease. Researchers led by Ankit A. Desai, MD, associate professor of medicine at the Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine, have been awarded a $3 million grant by the U.S. Department of Defense to evaluate the efficacy of this drug.

3 Jan 2024

"Genetic priority score" promises to revolutionize drug development

Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel "genetic priority score" (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score.

3 Jan 2024

Novel exercise approach offers significant benefits for children with cerebral palsy

Children with cerebral palsy (CP) have reported significant gains in cardiovascular fitness and mobility after taking part in a landmark research project led by The University of Queensland.

3 Jan 2024

Are pan-coronavirus vaccines an achievable goal in providing broad protection against human coronaviruses?

The current achievements in the development of a pan-coronavirus vaccine.

3 Jan 2024

Large study debunks hope for breast milk-based enrichment in preterm care

Infants born extremely prematurely need to get enrichment as an addition to breast milk. But does it make any difference whether the enrichment is made from breast milk or cow's milk when it comes to the risk of severe complications in children?

2 Jan 2024

Simple mail trick doubles liver cancer screening rates for high-risk patients

Liver cancer screening among patients with cirrhosis almost doubled when they were mailed a signed order from their specialist, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.

22 Dec 2023

Citrus supplement may ease knee swelling and pain after surgery

For patients undergoing total knee arthroplasty (TKA), treatment with diosmin – a flavonoid supplement derived from citrus fruits –reduced swelling of the knee and leg and some measures of associated pain can be achieved, reports a clinical trial in The Journal of Bone & Joint Surgery.

22 Dec 2023

Recent urology trials more likely to include data on harmful effects of treatments

In recent years, clinical trial reports in major urology journals have been more likely to include data on harmful effects of treatments, reports a study in the January issue of The Journal of Urology®, an Official Journal of the American Urological Association (AUA).

21 Dec 2023

St. Jude researchers reveal structure of Parkinson's-linked proteins

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

21 Dec 2023

Groundbreaking treatment tool being developed for male breast cancer diagnosis

Doctors diagnosed Christopher Gregg, Ph.D., member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute at the University of Utah (the U) and neuroscientist and professor of neurobiology and human genetics at the U, with stage 4 metastatic breast cancer in 2018.

21 Dec 2023

Clinical Trial News and Research

Researchers identify mechanism that causes gastrointestinal problems with cancer immunotherapy

Migraine symptoms linked to retinal blood flow changes

Stapled lipopeptides show promise as broad-spectrum antiviral agents

Psychedelic drug offers lifesaving relief for veterans plagued by traumatic brain injury

High-resolution map of the neuroblastoma immune landscape points to new target for immunotherapy

Stanford Medicine researchers demonstrate new way to temporarily heighten hypnotizablity

PharmaKure granted MHRA Clinical Trial Authorisation (CTA) for PK051 for the treatment of mild cognitive impairment due to Alzheimer’s Disease

Sugar showdown: Which sweetener impacts insulin sensitivity the most?

Rare immune cell holds key to predicting melanoma treatment success

$4.9 million grant awarded to build EndO-trial consortium for improving the lives of Crohn's patients

Existing beta blocker investigated as novel sickle cell therapy

"Genetic priority score" promises to revolutionize drug development

Novel exercise approach offers significant benefits for children with cerebral palsy

Are pan-coronavirus vaccines an achievable goal in providing broad protection against human coronaviruses?

Large study debunks hope for breast milk-based enrichment in preterm care

Simple mail trick doubles liver cancer screening rates for high-risk patients

Citrus supplement may ease knee swelling and pain after surgery

Recent urology trials more likely to include data on harmful effects of treatments

St. Jude researchers reveal structure of Parkinson's-linked proteins

Groundbreaking treatment tool being developed for male breast cancer diagnosis

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