Mutation News and Research

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Colorectal Cancer Project launches to improve understanding of the disease and accelerate research

Count Me In, a nonprofit cancer research initiative, is inviting all patients across the United States and Canada who have ever been diagnosed with colorectal cancer to participate in research and help drive new discoveries related to this disease.

14 Sep 2021

Researchers discover new pathway that makes drugs less effective in bowel cancer patients

Leading scientists at the University of Birmingham have discovered a previously unknown pathway that prevents specific drugs from working in patients with bowel cancer.

14 Sep 2021

Study finds possible direct connection between neurodegenerative diseases and the herpesvirus

A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1.

13 Sep 2021

Functional impairment of HIV-specific T cells precedes aborted virus control

HIV is a master of evading the immune system, using a variety of methods to prevent the body from being able to find and kill it.

13 Sep 2021

First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

A research team from the Universitat Autònoma de Barcelona has generated the first rat model recapitulating all disabling alterations experienced by patients with Mucopolysaccharidosis type IVA, also known as Morquio A disease.

12 Sep 2021

Cellular program could turn T cells into effective cancer killers

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

9 Sep 2021

Self-correcting genetic mutations may protect patients with shortened telomeres from blood cancers

People with rare disorders that cause shortened telomeres — protective caps that sit at the end of chromosomes — may be more likely to have blood cancers such as leukemia or myelodyplastic syndrome.

8 Sep 2021

Advancements in the diagnosis and treatment of prostate cancer are saving more lives

Prostate cancer is the most common type of cancer among men in the United States aside from skin cancer, according to the Centers for Disease Control and Prevention.

8 Sep 2021

Study focuses on psychiatric, cognitive symptoms emerging at early stages of Huntington's disease

Psychiatric and cognitive symptoms emerge at an early stage in Huntington's disease. However, research so far has mainly focused on movement impairment, a symptom associated with the more advanced stages of the disease.

7 Sep 2021

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

7 Sep 2021

Delta variant has a more diverse repertoire of mutations than other variants

In a paper, nearly 2 million SARS-CoV-2 genomes from around the world were analyzed, finding great diversity within the delta variant that exceeds that observed in the more widely spread alpha variant.

6 Sep 2021

Is the SARS-CoV-2 Lambda variant more vaccine-resistant than the Delta variant?

Researchers in the USA and China recently published a report in which they discussed the potential factors that confer high infectivity and immune resistance on the Delta and Lambda variants.

6 Sep 2021

Characterization of SARS-CoV-2 viral trajectory

In a study available on the preprint server medRxiv* researchers aimed to characterize early viral shedding in patients with incident infection. Read more here.

6 Sep 2021

Study finds SARS-CoV-2 affects the brain by binding with MAO enzymes

A new study by researchers in Croatia and Slovenia shows the SARS-CoV-2 spike protein has an affinity towards monoamine oxidases (MAO) enzymes. Changes in MAO levels have been the culprit for several neuropsychiatric disorders such as Parkinson’s or Alzheimer’s disease.

6 Sep 2021

Study finds a restricted number of possible escape mutations for SARS-CoV-2 Delta variant

The emergence of escape mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is somewhat less likely for the Delta variant in comparison with the original or wild type virus, shows a recent study currently available on the bioRxiv* preprint server while it undergoes peer review.

5 Sep 2021

Efficacy of vaccines against the SARS-CoV-2 Delta variant

A new study uses statistical models to determine vaccine efficacy against the various SARS-CoV-2 variants and clinical endpoints for SARS-CoV-2 variants.

5 Sep 2021

Scientists identify novel mechanism that links genetic defect in IBD patients to gut leakiness

A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier.

3 Sep 2021

Study establishes a new resource for exploring and understanding Alzheimer's disease

A study led by researchers from Brigham and Women's Hospital has established a new resource for exploring and understanding Alzheimer's disease (AD) on an individualized level.

2 Sep 2021

Trial tests effectiveness of two prospective stroke therapies over standard of care

Another goal of the study is to screen all participants for a mutation known to prevent clopidogrel, a prodrug, from being fully metabolized into its active form.

2 Sep 2021

Distinct changes found in cancer and non-cancer immune cells in Waldenstrom macroglobulinemia

A new study by researchers at Winship Cancer Institute of Emory University finds that cancer-associated mutations originate in blood progenitor cells, leading to distinct changes in both cancer and non-cancer immune cells in Waldenstrom macroglobulinemia (WM), a type of non-Hodgkin lymphoma and its precursor IgM monoclonal gammopathy of undetermined significance (MGUS).

2 Sep 2021

Mutation News and Research

Colorectal Cancer Project launches to improve understanding of the disease and accelerate research

Researchers discover new pathway that makes drugs less effective in bowel cancer patients

Study finds possible direct connection between neurodegenerative diseases and the herpesvirus

Functional impairment of HIV-specific T cells precedes aborted virus control

First rat model recapitulates all disabling alterations experienced by patients with Morquio A disease

Cellular program could turn T cells into effective cancer killers

Self-correcting genetic mutations may protect patients with shortened telomeres from blood cancers

Advancements in the diagnosis and treatment of prostate cancer are saving more lives

Study focuses on psychiatric, cognitive symptoms emerging at early stages of Huntington's disease

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Delta variant has a more diverse repertoire of mutations than other variants

Is the SARS-CoV-2 Lambda variant more vaccine-resistant than the Delta variant?

Characterization of SARS-CoV-2 viral trajectory

Study finds SARS-CoV-2 affects the brain by binding with MAO enzymes

Study finds a restricted number of possible escape mutations for SARS-CoV-2 Delta variant

Efficacy of vaccines against the SARS-CoV-2 Delta variant

Scientists identify novel mechanism that links genetic defect in IBD patients to gut leakiness

Study establishes a new resource for exploring and understanding Alzheimer's disease

Trial tests effectiveness of two prospective stroke therapies over standard of care

Distinct changes found in cancer and non-cancer immune cells in Waldenstrom macroglobulinemia

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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