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Nintedanib drug can benefit patients with broad range of scarring lung diseases

Nintedanib, a medication approved for the treatment of idiopathic pulmonary fibrosis, slows the decline in lung function among patients with a broad range of scarring lung diseases.

30 Sep 2019

Combination of two immunotherapy drugs stops or reverses progression of advanced melanoma

A combination of two immunotherapy drugs, ipilimumab and nivolumab, has stopped or reversed the progression of advanced melanoma for five years or more in one in two patients, according to a study led by The Royal Marsden NHS Foundation Trust.

28 Sep 2019

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that initial treatment with the PARP inhibitor veliparib in combination with chemotherapy significantly increased progression-free survival for patients with newly diagnosed, metastatic high-grade serous ovarian cancer, according to the results of the VELIA trial.

28 Sep 2019

Lipid produced in response to cold helps reduce blood sugar

Researchers based in Brazil, the United States and Germany have discovered that 12-HEPE, a lipid produced in response to cold by brown adipose tissue in the human body, helps reduce blood sugar. The results of their experiments with mice pave the way for new treatments for diabetes.

27 Sep 2019

Ticagrelor monotherapy reduces bleeding while preserving ischemic benefit in high-risk PCI patients

New data from the randomized, placebo-controlled TWILIGHT trial found that compared to ticagrelor plus aspirin, ticagrelor monotherapy reduces bleeding events without increasing the risk of death, myocardial infarction, or stroke in high-risk patients who have undergone successful percutaneous coronary intervention and completed three months of dual antiplatelet therapy.

27 Sep 2019

High-risk heart patients may not require long-term aspirin use after stent placement

High-risk patients undergoing coronary stent procedures may not require long-term aspirin use after stent placement, Mount Sinai researchers report in a groundbreaking study

26 Sep 2019

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

An international, multicenter phase II clinical trial is evaluating the efficacy and safety of mavrilimumab co-administered with a 26-week corticosteroid taper in patients with giant cell arteritis.

26 Sep 2019

Long-term hormone therapy does more harm than good for men with low PSAs after prostate surgery

A secondary analysis of a recent clinical trial that changed the standard of care for men with recurring prostate cancer finds long-term hormone therapy does more harm than good for many men and calls for rethinking treatment guidelines based on a patient's post-operative prostate-specific antigen (PSA) level.

26 Sep 2019

Researchers use AI to predict depression outcomes

The psychiatry field has long sought answers to explain why antidepressants help only some people.

25 Sep 2019

BCG vaccination in childhood could decrease risk of lung cancer

A common tuberculosis vaccine could decrease the risk of lung cancer if administered during early childhood, according to a study published Sept. 25 in JAMA Network Online.

25 Sep 2019

Cheaper drug equally effective in preserving cardiovascular function in boys with DMD

A new clinical trial conducted at The Ohio State University Wexner Medical Center found a cost-effective generic medication works just as well as a more expensive drug in preserving cardiovascular function in boys with Duchenne muscular dystrophy (DMD).

24 Sep 2019

Unexpected mechanism of action found with sertraline

A new study on sertraline, which is one of the most popular drugs for depression and anxiety, shows that its efficacy is undoubted, but it operates primarily by reducing anxiety rather than depression.

23 Sep 2019

Fluoride varnish: is there any benefit?

Though hugely popular for preventing dental decay in children, fluoride varnish may not be anything but an expensive placebo, it turns out, from the results of a new study by University of Washington researchers.

20 Sep 2019

Diabetes drug can also be used to treat heart failure

Dapagliflozin, a drug that is already used to successfully treat type 2 diabetes (T2D) and prevent development of heart failure, can also be used to treat pre-existing heart failure, even in patients without T2D.

19 Sep 2019

Early combination therapy provides long-term benefits for patients with type 2 diabetes

A new study, VERIFY (Vildagliptin Efficacy in combination with metfoRmIn For earlY treatment of type 2 diabetes) presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Barcelona, Spain (16-20 Sept, 2019), and published simultaneously in The Lancet, is the first to show that early combination therapy using vildagliptin and metformin in patients newly diagnosed with type 2 diabetes (T2D) leads to better long-term blood sugar control and a reduced rate of treatment failure than metformin alone.

19 Sep 2019

New results revealed from pilot stem cell study for stroke

Researchers led by Sean I. Savitz, MD, reported today in the journal Stem Cells that bone marrow cells used to treat ischemic stroke in an expanded Phase I trial were not only safe and feasible, but also resulted in enhanced recovery compared to a matched historical control group.

17 Sep 2019

Pre-SRT PSA could serve as prognostic and predictive biomarker of benefit from hormone therapy

Initial results of NRG Oncology Clinical Trial RTOG 9601 in men with biochemically recurrent prostate cancer receiving salvage radiotherapy demonstrated improvement in OS from the addition of long-term hormone therapy to SRT.

17 Sep 2019

Deep brain magnetic stimulation can improve symptoms of OCD

Researchers have found that focusing powerful non-invasive magnet stimulation on a specific brain area can improve the symptoms of Obsessive Compulsive Disorder.

8 Sep 2019

FDA approves first drug to treat patients with rare lung condition

The U.S. Food and Drug Administration today approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma, called SSc-ILD. It is the first FDA-approved treatment for this rare lung condition.

7 Sep 2019

Mouthwash impacts the effects of exercise

Scientists have long known that the blood pressure drops after exercise but the mechanism has not been fully elucidated. A new study shows that bacteria in the mouth, which produce nitrite, is key to the whole process. The use of mouthwash to reduce the number of these bacteria prevents the expected benefit of exercise on the blood pressure.

4 Sep 2019

Placebo News and Research

Nintedanib drug can benefit patients with broad range of scarring lung diseases

Combination of two immunotherapy drugs stops or reverses progression of advanced melanoma

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

Lipid produced in response to cold helps reduce blood sugar

Ticagrelor monotherapy reduces bleeding while preserving ischemic benefit in high-risk PCI patients

High-risk heart patients may not require long-term aspirin use after stent placement

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

Long-term hormone therapy does more harm than good for men with low PSAs after prostate surgery

Researchers use AI to predict depression outcomes

BCG vaccination in childhood could decrease risk of lung cancer

Cheaper drug equally effective in preserving cardiovascular function in boys with DMD

Unexpected mechanism of action found with sertraline

Fluoride varnish: is there any benefit?

Diabetes drug can also be used to treat heart failure

Early combination therapy provides long-term benefits for patients with type 2 diabetes

New results revealed from pilot stem cell study for stroke

Pre-SRT PSA could serve as prognostic and predictive biomarker of benefit from hormone therapy

Deep brain magnetic stimulation can improve symptoms of OCD

FDA approves first drug to treat patients with rare lung condition

Mouthwash impacts the effects of exercise

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