Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

High dose radiation therapy linked to shorter survival times in NSCLC patients

A genetic analysis of non-small cell lung cancer (NSCLC) patients on the phase III NRG Oncology RTOG 0617 clinical trial assessing radiation dose discovered that high dose radiation therapy is associated with shorter survival times among patients with a radiation-sensitive genotype in DNA repair pathway.

29 Oct 2020

Rapid CD169 assay for COVID-19 screening

Researchers in France have conducted a study demonstrating the sensitivity of a rapid flow cytometry assay that could be used to screen for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

27 Oct 2020

Dietary 1H-NMR “Fingerprints” Could Help Fight Against Chronic Disease

Metabolic urine profiling could provide an approach to understand what people have been eating, without them needing to tell you. Here, researchers from Imperial College London, Prof Gary Frost, Prof Elaine Holmes, and Dr. Isabel Garcia-Perez, explain why this could be invaluable to both nutritional research and individuals.

From Bruker BioSpin Group 27 Oct 2020

New technique can detect TDP-43 protein in patients with ALS and frontotemporal dementia

A test to diagnose two very serious diseases such as ALS and FTD when the pathologies have not yet appeared, thereby providing doctors and patients with essential information tools to tackle them early and develop new treatments.

27 Oct 2020

Cellular senescence variations may control health and onset of age-related diseases

Researchers from Kumamoto University, Japan have proposed that cellular senescence variations during the aging process could lead to control of health and onset of age-related diseases.

27 Oct 2020

Multimodal mapping of immune landscape in pancreatic cancer could guide personalized therapies

Pancreatic cancer has remained resistant to immunotherapies that are revolutionizing the treatment of many types of cancer.

27 Oct 2020

Biodynamic imaging illuminates ovarian cancer treatments

Scientists estimate that nearly 60% of all cancer patients do not respond effectively to chemotherapy treatments. Even worse - many of those same patients experience toxic and sometimes deadly side effects.

22 Oct 2020

Scientists develop a way to accurately detect and monitor common pediatric brain cancer

A team of scientists at Texas A&M University, Baylor College of Medicine and Texas Children's Hospital have developed a way to more accurately both detect and monitor a common type of pediatric brain cancer, setting the stage for giving clinicians a real-time view into how the cancer responds to treatment.

21 Oct 2020

Gut hormone found to be key regulator of new nerve cells in the adult brain

A gut hormone, ghrelin, is a key regulator of new nerve cells in the adult brain, a Swansea-led research team has discovered. It could help pave the way for new drugs to treat dementia in patients with Parkinson's Disease.

21 Oct 2020

Study identifies potential target for treating polyploidal giant cancer cells

As researchers and medical professionals work to develop new treatments for cancer, they face a variety of challenges.

21 Oct 2020

High flavanol diet associated with lower blood pressure

People who consume a diet including flavanol-rich foods and drinks, including tea, apples and berries, could lead to lower blood pressure, according to the first study using objective measures of thousands of UK residents' diet.

21 Oct 2020

Brain imaging biomarker may help predict treatment response in patients with psychiatric disorders, study reveals

Cohen Veterans Bioscience, a non-profit research biotech advancing brain health solutions, today announces findings from a study which generates new evidence in support of a critical brain imaging biomarker, that may help guide people who suffer from post-traumatic stress disorder or major depressive disorder towards the most effective treatment.

21 Oct 2020

WSU scientists develop new method to detect Alzheimer's biomarkers

Washington State University scientists have developed a method to detect the biomarkers for Alzheimer's disease that is 10 times more sensitive than current blood testing technology.

20 Oct 2020

The connection between severe COVID-19 and white blood cell counts

However, in other research, white blood cells' exact roles and subtypes in severe COVID-19 are still unclear. The team writes, "It is unknown if blood cell counts before infection are associated with the risk of developing severe COVID-19." They explained that the numbers of these cell types could be influenced by several factors such as age, gender, disease status, and medications.

19 Oct 2020

Immunoglobulin M ACE2 autoantibodies associated with severe COVID-19

As the COVID-19 pandemic progresses with little prospect of immediate relief, a recent study by Johns Hopkins University researchers published on the preprint server medRxiv* in October 2020 discusses the association of Immunoglobulin M (IgM) autoantibodies against the host receptor that binds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with severe disease via vascular endothelial damage. This could help develop better therapies and prognostic criteria.

19 Oct 2020

Serum metabolite profile can help identify individuals at risk of alcohol-related disease

A new study from the University of Eastern Finland is the first in the world to show that the serum metabolite profile can be used to identify individuals likely at risk of developing an alcohol-related disease in the future.

19 Oct 2020

CBD could reduce lung damage caused by COVID-19

One way CBD appears to reduce the "cytokine storm" that damages the lungs and kills many patients with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this storm.

19 Oct 2020