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Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

A recent article posted to the bioRxiv* preprint server identified numerous efficacious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from convalescent SARS-CoV-2 patients.

23 Jun 2022

Researchers improve the ability of a protein to repair oxidative DNA damage

Researchers at Karolinska Institutet and SciLifeLab in Sweden describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function.

23 Jun 2022

SARS-CoV-2 evades natural killer cell cytotoxic responses

In a recent study posted to the bioRxiv* preprint server, researchers at Stanford University School of Medicine revealed the mechanism via severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escapes natural killer (NK) cell cytotoxic reactions.

22 Jun 2022

Researchers map cancer driver mutations across the human genome

In a recent study published in Nature Biotechnology, researchers explored the causes of cancer by mapping somatic mutation rates across the human genome.

22 Jun 2022

Potential SARS-CoV-2 antivirals based on host miRNAs

A recent research paper posted to the bioRxiv* preprint server demonstrated micro ribonucleic acids (miRNAs) as potential antiviral options against various coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

21 Jun 2022

Insufficient drug exposure most likely to cause COVID-19 rebound

Paxlovid is the leading oral medication for preventing severe cases of COVID-19 in high-risk individuals.

21 Jun 2022

Erectile dysfunction drugs may be able to boost the effect of chemotherapy in esophageal cancer

A group of drugs commonly used to treat erectile dysfunction may be able to boost the effect of chemotherapy in esophageal cancer, according to new research funded by Cancer Research UK and the Medical Research Council.

21 Jun 2022

The effect of the COVID-19 BNT162b2 vaccine on semen parameters among semen donors

Researchers explored the impact of COVID-19 BNT162b2 (Pfizer) vaccinations on male fertility among semen donors in Israel.

21 Jun 2022

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

The impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant

Researchers assessed the impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant.

21 Jun 2022

Implications of impaired type I interferon immunity and increasing COVID-19 severity

Researchers demonstrated that impaired type I interferon immunity is associated with increasing coronavirus disease 2019 severity.

20 Jun 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

Study explains the structural basis of higher ACE2 binding affinity of Omicron sub-variants

A team of scientists from China has recently deciphered the structural basis of comparatively higher binding affinity of two Omicron sub-variants, namely B.1.1 and B.2, for human angiotensin-converting enzyme 2 (ACE2).

17 Jun 2022

Researchers investigate COVID fog and chemokine C–C motif ligand 11

Researchers assessed the characteristics of the brain fog reported by some COVID-19 patients.

17 Jun 2022

Scientists explore effectiveness of neutralizing antibodies against SARS-CoV-2 Omicron variant

Researchers assessed the impact of SARS-CoV-2-neutralizing antibodies on the SARS-CoV-2 Omicron variant.

17 Jun 2022

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

In a recent study posted to the bioRxiv* pre-print server, researchers at Cornell University College of Veterinary Medicine and the University of Illinois Urbana-Champaign compared the infection dynamics, pathogenicity, and tissue tropism of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in adult cats.

17 Jun 2022

Enzyme News and Research

Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

Researchers improve the ability of a protein to repair oxidative DNA damage

SARS-CoV-2 evades natural killer cell cytotoxic responses

Researchers map cancer driver mutations across the human genome

Potential SARS-CoV-2 antivirals based on host miRNAs

Insufficient drug exposure most likely to cause COVID-19 rebound

Erectile dysfunction drugs may be able to boost the effect of chemotherapy in esophageal cancer

The effect of the COVID-19 BNT162b2 vaccine on semen parameters among semen donors

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

The impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant

Implications of impaired type I interferon immunity and increasing COVID-19 severity

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

Study explains the structural basis of higher ACE2 binding affinity of Omicron sub-variants

Researchers investigate COVID fog and chemokine C–C motif ligand 11

Scientists explore effectiveness of neutralizing antibodies against SARS-CoV-2 Omicron variant

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

Novel luminescent biosensor detects SARS-CoV-2 spike protein using cell phone camera

Glucose meter can detect SARS-CoV-2 antibodies in patient samples

Type I interferons play crucial role in fending off SARS-CoV-2

Effectiveness of a hybrid vaccine against COVID-19 and influenza

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo