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Tumors use enzyme to recruit regulatory T-cells and suppress immune response

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.

17 Aug 2007

Reactivating a critical gene lost in kidney cancer reduces tumor growth

Researchers at Mayo Clinic Jacksonville, have found that a key gene is often silenced in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared.

17 Aug 2007

Sirtuin protein instrumental in fat production and metabolism

A new Joslin Diabetes Center-led study has identified a protein found in fat cells that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk for type 2 diabetes.

17 Aug 2007

The role of estrogens and polyphenols in hypertension and diabetes

Menopausal women are at relatively high risk for memory loss, high blood pressure (hypertension) and diabetes.

12 Aug 2007

Light-activated molecules used to induce apoptosis in cancer cells

A key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often don't discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance.

12 Aug 2007

Sex hormones play a significant role in the development of diabetic kidney disease

Women have a "female advantage" when it comes to chronic kidney disease. When compared to men, they have fewer and less severe episodes of this disorder throughout most of their lives.

11 Aug 2007

Sex steroids, platelet aggregation and inflammation

In women, hormone therapy is a risk factor for venous thrombosis, a blood clot forming deep inside the vein. Despite the fact that the disorder is rare, it increases exponentially during menopause and can be deadly.

11 Aug 2007

Testosterone replacement therapy for men

For decades, older women have taken hormone replacements to replenish estrogen and progesterone levels lost to aging.

9 Aug 2007

Estrogen deficiency may trigger the development of high blood pressure and obesity in aged females

At menopause, women lose hormone protection against heart (cardiovascular) and kidney (renal) diseases, and are likely to become obese. A research team has tested the idea that estrogen deficiency in aged females may trigger the development of high blood pressure and obesity.

9 Aug 2007

New approach to assessing clot risk in menopausal women

In women, hormone therapy is a risk factor for venous thrombosis, a blood clot forming deep inside the vein.

9 Aug 2007

Endothelial nitric oxide synthase gene linked to brain aneurysm formation

University of Cincinnati (UC) neurovascular researchers have identified a gene that, when suppressed or completely absent, may predispose a person to brain aneurysms.

8 Aug 2007

Green tea holds promise for psoriasis and dandruff

Green tea could hold promise as a new treatment for skin disorders such as psoriasis and dandruff, Medical College of Georgia researchers say.

7 Aug 2007

Nimesulide delays pancreatic cancer precursors in mice

Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA.

2 Aug 2007

COX-2 inhibitors delay pancreatic cancer precursors in mice

Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA.

1 Aug 2007

The future of Alzheimer's disease research

Imagine the day when a routine visit to the family doctor includes a simple blood test to predict the risk for developing Alzheimer's disease (AD).

26 Jul 2007

Researchers identify gene-regulating protein in the brain that triggers ability to cope with

Researchers have identified a gene-regulating protein in the brains of mice that triggers the animals' ability to cope with the "behavioral despair" caused by inescapable stress.

19 Jul 2007

Suicide gene therapy for cancer

Cutting-edge research at South Dakota State University may yield a new therapy that targets only cancer cells, leaving healthy cells unharmed.

18 Jul 2007

Peregrine licenses worldwide rights to a novel anti-angiogenesis technology

Peregrine Pharmaceuticals, Inc. has announced that it has licensed worldwide exclusive rights to a novel anti-angiogenesis technology from The University of Texas M. D. Anderson Cancer Center.

10 Jul 2007

Gene therapy offers promising approach to tackle pancreatic cancer

A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity, researchers from The University of Texas M. D. Anderson Cancer Center report in the July 9 edition of Cancer Cell.

10 Jul 2007

Soil increases the oral transmissibility of deadly prions

The rogue proteins that cause chronic wasting disease (CWD) exhibit a dramatic increase in their infectious nature when bound to common soil particles, according to a new study.

9 Jul 2007