Mouse Model News and Research

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Proteins that protect neurons from destruction can be delivered through nose

Protective proteins that mitigate the destruction of nerve cells after a stroke can be administered into the brain through the nose, as Heidelberg University researchers demonstrated using a mouse model.

24 Aug 2018

New project receives $3.2 million grant to investigate secrets of programmed cell death in Alzheimer's

Most neurons in the human brain live out their lives, enduring the processes of aging before eventually dying. Some, however, choose a more violent route: suicide.

24 Aug 2018

Researchers work to create humanized mouse model to test immunotherapies

If a new anti-cancer drug shows promise in a Petri dish, often the next step is to test the drug's effect in mice. This system tends to work well with drugs that directly target cancer, but breaks down with immunotherapies.

24 Aug 2018

Researchers uncover how RNA regulates genes during critical stage in embryonic brain development

Scientists at the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues discovered how a type of RNA, called Evf2 enhancer RNA, regulates key genes during a critical stage in embryonic brain development.

24 Aug 2018

Research identifies cell signaling pathways related to endocannabinoid system in worms

Like mammals, parasitic worms have an endocannabinoid system that may help the worm and the hosts it infects survive by reducing pain and inflammation in the host, according to a "wild" new discovery by an interdisciplinary research team at the University of California, Riverside.

23 Aug 2018

Scientists discover how a protein in the brain maintains 'energy rheostasis'

Scientists at the University of Michigan and Vanderbilt University have identified the function of a protein that has been confounding metabolism researchers for more than two decades. And it may have implications both for treating obesity and for understanding weight gain during pregnancy and menopause.

23 Aug 2018

Scientists develop universal vaccine with the potential to protect against multiple flu strains

Researchers have developed a universal vaccine that can protect against multiple strains of influenza in animals.

22 Aug 2018

Discovery could lead to new targeted treatment for people with lung cancer

Scientists have identified a key molecular player in a subtype of lung cancer which could lead to a new way to tackle the disease, according to research published in Nature Communications.

22 Aug 2018

Study compares T-cell signaling patterns in two different CAR designs

CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have not been thoroughly examined.

21 Aug 2018

A form of vitamin B3 shows potential to prevent acute kidney injury

Acute kidney injury, an often fatal condition without a specific treatment, affects up to 10 percent of all hospitalized adults in the United States and 30-40 percent in low-income countries.

21 Aug 2018

Thrombospondin-1 contributes to development of aortic aneurysm in mice and humans, study finds

Researchers centered at the University of Tsukuba and Kansai Medical University in Japan reveal matricellular protein Thrombospondin-1 (Thbs1) contributes to the development of aortic aneurysm in mice and humans.

20 Aug 2018

Understanding How Antibodies Shape the Gut Microbiome

Dr. Keiichiro Suzuki discusses the importance of IgA in the human body, and his recent research study, which showed that IgA interacts with the gut microbiome and promotes the growth of healthy bacteria.

20 Aug 2018

Brief exposures to stressors can be beneficial to cells, shows study

We've all heard the expression: "what doesn't kill you makes you stronger." Now, research led by a Salk Institute scientist suggests why, at a cellular level, this might be true.

17 Aug 2018

Penn researchers develop first mouse model of idiopathic pulmonary fibrosis

The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the ability to observe and understand the disease.

16 Aug 2018