Mouse Model News and Research

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MODEL-AD Center releases eight new mouse models for Alzheimer's research

The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer's disease (AD), has released eight new models carrying genetic mutations found in patients.

23 Jul 2018

Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice

Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed?

20 Jul 2018

High-fat diet and systemic inflammation contribute to progression of prostate cancer

Osaka University-led study shows how a high-fat diet and systemic inflammation contribute to prostate cancer progression

18 Jul 2018

Researchers identify key protein involved in irregular brain cell activity

In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor suppressor.

17 Jul 2018

New drug strategy can alleviate multiple behavioral, cellular deficiencies in FXS mouse model

Research in mice shows that a pharmacological strategy can alleviate multiple behavioral and cellular deficiencies in a mouse model of fragile X syndrome, the most common inherited form of intellectual disability and a major single-gene cause of autism spectrum disorders.

13 Jul 2018

New technique measures how well cancer drugs reach their targets

Scientists have developed a technique that allows them to measure how well cancer drugs reach their targets inside the body.

13 Jul 2018

UCLA researchers uncover gene that controls equilibrium of bone and fat in bone marrow

In an unexpected discovery, UCLA researchers have found that a gene previously known to control human metabolism also controls the equilibrium of bone and fat in bone marrow as well as how an adult stem cell expresses its final cell type.

13 Jul 2018

Novel therapeutic approach alleviates ALS-related muscular atrophy in mouse models

Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig's disease, according to a new study out of Case Western Reserve University School of Medicine.

12 Jul 2018

Study reveals link between gastrointestinal flora and acute lung injury after blood transfusions

Knowledge that the gastrointestinal flora affects both healthy physiological processes and various disease mechanisms has increased in recent years.

11 Jul 2018

Mice study shows promise for treating genetic conditions during fetal development

Researchers at Carnegie Mellon University and Yale University have for the first time used a gene editing technique to successfully cure a genetic condition in a mouse model.

10 Jul 2018

Spread of pancreatic cancer to the liver or lungs depends on plasticity of tumor cells

Pancreatic cancer often spreads, forming metastases in the liver or lungs. The prognosis is better for patients with metastases in the lungs.

9 Jul 2018

Scientists discover new target to treat blood vessel damage in diabetes

In diabetes, both the tightly woven endothelial cells that line our blood vessels and the powerhouses that drive those cells start to come apart as early steps in the destruction of our vasculature.

9 Jul 2018

UT Southwestern researchers uncover body's microreactors for innate immunity

A DNA-sensing enzyme forms droplets that act as tiny bioreactors creating molecules to stimulate innate immunity – the body's first response to infection, UT Southwestern researchers report. The work, reported today in the journal Science, could lead to novel treatments for infections, autoimmune disease, and cancer.

9 Jul 2018

Nanofiber-based wound dressings loaded with vitamin D spur production of antimicrobial peptide

Nanofiber-based wound dressings loaded with vitamin D spur the production of an antimicrobial peptide, a key step forward in the battle against surgical site infections, or SSIs.

6 Jul 2018

New clues may lead to rapid detection of sepsis

Sepsis is an infection that kills as many Americans each year as stroke and Alzheimer's combined-about 250,000-but very little has changed in the treatment of this age-old scourge.

3 Jul 2018

Established lung fibrosis can be reversed using diabetes drug treatment

Researchers at the University of Alabama at Birmingham have shown - for the first time - that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism.

2 Jul 2018

Glucose-based dietary supplement increases muscle-force in Duchenne muscular dystrophy mouse

A dietary supplement derived from glucose increases muscle-force production in the Duchenne muscular dystrophy mouse model by 50% in ten days, according to a study conducted by researchers from Université Laval's Faculty of Medicine and Centre hospitalier universitaire de Québec Research Centre-Université Laval.

30 Jun 2018

Mouse Model News and Research

MODEL-AD Center releases eight new mouse models for Alzheimer's research

Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice

High-fat diet and systemic inflammation contribute to progression of prostate cancer

Researchers identify key protein involved in irregular brain cell activity

New drug strategy can alleviate multiple behavioral, cellular deficiencies in FXS mouse model

New technique measures how well cancer drugs reach their targets

UCLA researchers uncover gene that controls equilibrium of bone and fat in bone marrow

Novel therapeutic approach alleviates ALS-related muscular atrophy in mouse models

Study reveals link between gastrointestinal flora and acute lung injury after blood transfusions

Mice study shows promise for treating genetic conditions during fetal development

Spread of pancreatic cancer to the liver or lungs depends on plasticity of tumor cells

Scientists discover new target to treat blood vessel damage in diabetes

UT Southwestern researchers uncover body's microreactors for innate immunity

Nanofiber-based wound dressings loaded with vitamin D spur production of antimicrobial peptide

New clues may lead to rapid detection of sepsis

Established lung fibrosis can be reversed using diabetes drug treatment

Glucose-based dietary supplement increases muscle-force in Duchenne muscular dystrophy mouse

Modified natural killer cells may be new player in CAR-T immunotherapies

New mouse model could shed light on autism subtype

Penn cancer researchers reveal secrets of 'hot' and 'cold' pancreatic tumors

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