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Digital warm-start CRISPR assay enables sensitive quantitative detection of SARS-CoV-2 in clinical samples

In a recent medRxiv* preprint paper, researchers from the University of Connecticut Health Center in the United States unveil their digital warm-start CRISPR (WS-CRISPR) method for stringent and sensitive quantitative detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples of patients with coronavirus disease (COVID-19).

24 Nov 2020

Measurement of Cancer Biomarker Enrichment in Exosomes

Postnova Analytics reports that researchers from the University of Utah (Salt Lake City, USA) have used a novel combination of Asymmetrical Flow Field-Flow Fractionation and Centrifugal Field-Flow Fractionation to measure cancer biomarker enrichment in exosomes.

From Postnova Analytics 24 Nov 2020

Biosensor assay SARS-CoV-2 antibody test may predict COVID-19 severity in patients

Researchers in New York, USA, have found an association of mortality with an early humoral response to SARS-CoV-2 infection within the first few days after onset of symptoms (DAOS), using a highly sensitive and automated testing-on-a-probe (TOP) biosensor assays for SARS-CoV-2.

24 Nov 2020

Early high-titer convalescent plasma prevents 75% of severe COVID-19 in elderly

A promising new clinical study published on the preprint server medRxiv reports that if convalescent plasma with a high titer of antibodies is given early in the course of COVID-19 in elderly patients, the risk of severe illness is reduced by 73%.

24 Nov 2020

New CDC report describes COVID-19 in NYC in early spring

The Centres for Disease Control and Prevention (CDC), in its Morbidity and Mortality Weekly Report (MMWR), has published an update on the outbreak in New York City. The report is titled, "COVID-19 Outbreak — New York City, February 29–June 1, 2020".

23 Nov 2020

Mildly symptomatic COVID-19 patients may be contagious for longer than previously thought

Researchers in Brazil have reported two cases of people with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding infectious virus for a significantly longer period than has previously been reported.

23 Nov 2020

Repeat infection following COVID-19 recovery may not pose risk to close contacts

Researchers in China have conducted a study suggesting that people who have recovered from coronavirus disease 2019 (COVID-19) may not pose a risk to close contacts if they become reinfected with the causative agent severe acute respiratory syndrome coronavirus (SARS-CoV-2).

23 Nov 2020

SARS-CoV-2 spike deletion mutations may evade current vaccine candidates, study finds

A thought-provoking new study reports that the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antibodies elicited by natural infection may not be able to neutralize emerging strains that display deletion mutations in their genomic RNA.

23 Nov 2020

Greensboro North Carolina Company’s Dedication to Ensuring Laboratories have COVID-19 Supplies Now Offers One-Stop-Shop for PCR Instruments, Extraction Systems and Kits, POC COVID-19 Test Kits, and Supplies.

GREENSBORO, NC — (November 20, 2020) – Greensboro-based, Carolina Liquid Chemistries Corp. (CLC) has been tirelessly working since the beginning of the COVID-19 outbreak to provide high-quality testing kits and instruments to healthcare providers and laboratories as quickly as possible.

From Carolina Liquid Chemistries Corp. 23 Nov 2020

Study suggests neutralizing SARS-CoV-2 antibodies offer protection against reinfection

A new study published in November 2020 on the preprint server medRxiv* indicates that the chances of symptomatic infection are indeed much lower among the population with antibodies to the virus.

22 Nov 2020

Inexpensive, rapid-turnaround COVID-19 tests could eliminate the virus within weeks

Testing half the population weekly with inexpensive, rapid-turnaround COVID-19 tests would drive the virus toward elimination within weeks-- even if those tests are significantly less sensitive than gold-standard clinical tests, according to a new study published today by University of Colorado Boulder and Harvard University researchers.

20 Nov 2020

SARS-CoV-2 suppresses ACE2 activity in COVID-19 patients

A recent study conducted by a team of international scientists has revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19), suppresses the expression and function of human angiotensin-converting enzyme 2 (ACE2) and induces the expression of interferon-stimulated genes at the initial phase of infection. The study is currently available on the bioRxiv* preprint server.

20 Nov 2020

Scientists explain potential reasons for SARS-CoV-2 re-infection

A study, which was published in the journal New Microbes and New Infections, focused on the possible reasons for SARS-CoV-2 reinfection.

20 Nov 2020

Texas Heart Institute to participate in a study to treat ARDS in hospitalized COVID-19 patients

Texas Heart Institute has been selected as one of up to 60 sites in the world to participate in an international investigative study seeking to aid COVID-19 patients who develop acute respiratory distress syndrome (ARDS).

19 Nov 2020

Seroprevalence meta-analysis predicts 643 million already infected by SARS-CoV-2 globally

A recent systematic review and meta-analysis conducted by a team of international scientists reveal low seroprevalence of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the general population.

19 Nov 2020

SARS-CoV-2 is not associated with adverse pregnancy outcomes

A recent study examined the risks of SARS-CoV-2 infection during pregnancy, finding that no severe adverse outcomes are expected to either party.

19 Nov 2020

COVID-19 during pregnancy can cause placental inflammation and impaired immunity

A new study conducted by a team of researchers at Johns Hopkins University, USA, has observed how pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show stunted antiviral immune responses.

18 Nov 2020

Bioelectronic rapid test for COVID-19

A recent study presents a bioelectronic sensor platform to detect protein at the single-molecule level that is simple, rapid, and robust enough for widespread POC (point-of-care) or bedside application.

18 Nov 2020

Males may have higher but more transient SARS-CoV-2 immunity than females post-infection

Adding another piece to the puzzle that is coronavirus disease 2019 (COVID-19) serology, a new study published on the preprint server medRxiv* in November 2020 suggests that males have stronger but more transient anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protective immunity than females.

17 Nov 2020

COVID-19 outbreak on an American aircraft carrier: A case study in transmission

A new study showing the dynamics of infectious spread within close quarters of an aircraft carrier. The study presents a rich case study that may help us better understand the dynamics of SARS-CoV-2’s transmission and thereby fine-tune present policies that aim to prevent its spread.

16 Nov 2020

Polymerase News and Research

Digital warm-start CRISPR assay enables sensitive quantitative detection of SARS-CoV-2 in clinical samples

Measurement of Cancer Biomarker Enrichment in Exosomes

Biosensor assay SARS-CoV-2 antibody test may predict COVID-19 severity in patients

Early high-titer convalescent plasma prevents 75% of severe COVID-19 in elderly

New CDC report describes COVID-19 in NYC in early spring

Mildly symptomatic COVID-19 patients may be contagious for longer than previously thought

Repeat infection following COVID-19 recovery may not pose risk to close contacts

SARS-CoV-2 spike deletion mutations may evade current vaccine candidates, study finds

Greensboro North Carolina Company’s Dedication to Ensuring Laboratories have COVID-19 Supplies Now Offers One-Stop-Shop for PCR Instruments, Extraction Systems and Kits, POC COVID-19 Test Kits, and Supplies.

Study suggests neutralizing SARS-CoV-2 antibodies offer protection against reinfection

Inexpensive, rapid-turnaround COVID-19 tests could eliminate the virus within weeks

SARS-CoV-2 suppresses ACE2 activity in COVID-19 patients

Scientists explain potential reasons for SARS-CoV-2 re-infection

Texas Heart Institute to participate in a study to treat ARDS in hospitalized COVID-19 patients

Seroprevalence meta-analysis predicts 643 million already infected by SARS-CoV-2 globally

SARS-CoV-2 is not associated with adverse pregnancy outcomes

COVID-19 during pregnancy can cause placental inflammation and impaired immunity

Bioelectronic rapid test for COVID-19

Males may have higher but more transient SARS-CoV-2 immunity than females post-infection

COVID-19 outbreak on an American aircraft carrier: A case study in transmission

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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