immunity News and Research

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COVID-19 booster shots essential for maintaining long-term immunity against infection in older adults

In a study of more than 80 men and women from Baltimore, Maryland, Johns Hopkins researchers have added to evidence that COVID-19 booster shots are essential for maintaining long-term immunity against infection, particularly among older adults.

29 Sep 2022

Primary vaccinations and boosters effective in reducing COVID-19 severity during Delta and Omicron predominance

In a new study, researchers analyzed COVID-19 vaccination and surveillance data to understand the effect of primary vaccinations, boosters, and prior SARS-CoV-2 infections on severe COVID-19 outcomes and subsequent infections.

29 Sep 2022

Study examines the incidence of severe COVID-19 in fully vaccinated and boosted high-risk populations

In new research, scientists studied a cohort of patients at the U.S Veterans Health Administration facilities to determine the incidence of severe COVID-19 outcomes among individuals with primary and booster doses of any combination of BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines.

29 Sep 2022

Significant humoral immune evasion contributes to the emergence and rapid spread of Arg346-mutated BA.4 and BA.5 sublineages

=Researchers measured the neutralizing titers of plasma samples against the SARS-CoV-2 new variant of concern Omicron's sub-variants BA.4 and BA.5 with arginine (Arg)346 mutations.

29 Sep 2022

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

A new study showed that SARS-CoV-2 Spike N-glycosylation patterns, intracellular lectins, and the associated molecular chaperones play crucial roles in the viral-host-cell invasion and function.

28 Sep 2022

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

A recent study designed immunogens to induce antibodies against SARS-CoV-2 variants.

28 Sep 2022

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, primarily causes mild to moderate upper-respiratory tract illness. However, some individuals with COVID-19 develop severe infections and require hospital admission.

27 Sep 2022

Bile acids play an important role in regulating gut microbiome

Scientists performe in vitro and in vivo experiments to investigate the antimicrobial effects of different bile acids on various microorganisms.

27 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Evolution of pathogens during vaccination programs

New research summarized the current understanding of pathogen evolution.

27 Sep 2022

Some pre-existing conditions matter a lot more when assessing COVID-19 outcomes

A new paper in Biology Methods & Protocols, published by Oxford University Press, indicates that some pre-existing conditions - including degenerative neurological diseases, dementia, and severe disabilities - matter a lot more than once thought when assessing who is at risk for death due to COVID-19.

27 Sep 2022

How do clinical outcomes in patients infected with different Omicron subvariants differ?

Researchers compare the clinical outcomes, upper respiratory viral loads, and viral recovery of different SARS-CoV-2 Omicron subvariants on cell cultures.

27 Sep 2022

Differences in protection from previous infection or vaccination against infection with Omicron BA.4/5 or BA.2

Researchers investigated the differences in vaccination- and previous infection-induced immunities against the Omicron BA.2 and BA.4/5 subvariants of SARS-CoV-2.

27 Sep 2022

First data on Pfizer-BioNTech's Omicron BA.4/5 combination vaccine

In a recent study posted to the bioRxiv* preprint server, researchers from Germany and the United States analyzed the association between exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4/BA.5 spike glycoprotein and pan-Omicron neutralization.

27 Sep 2022

Researchers uncover a new way the immune system detects coronavirus infection

In a recent study posted to bioRxiv*, researchers in the United States demonstrated that the main protease (Mpro) of coronaviruses (CoVs) activates host inflammasome responses.

27 Sep 2022

Does leptin play a role in Parkinson’s disease?

Scientists review in vitro and in vivo evidence associated with Parkinson's disease and leptin.

26 Sep 2022

In vitro gut models reveal how microplastics affect the GI tract

Researchers hypothesize that exposure to polyethylene microplastics affect the human adult GI system in vitro under realistic conditions.

26 Sep 2022

UTHSC professor receives $5 million to explore the gut as therapeutic target for treating disease

Radhakrishna Rao, PhD, vice-chair and professor in the Department of Physiology at the University of Tennessee Health Science Center (UTHSC), has received two large national awards totaling $5 million for separate studies involving the gut as a therapeutic target for treating disease.

26 Sep 2022

Study demonstrates how pan-sarbecovirus ORF7a protein plays a role in evading host immunity

In a new study, researchers demonstrated how sarbecovirus family down-regulates major histocompatibility complex-I (MHC-I) surface expression to evade cellular immunity.

26 Sep 2022

Omicron BA.1 breakthrough infection in vaccinated individuals recall memory B cells to confer immunity

In a new study, researchers followed up with individuals vaccinated with a COVID-19 vaccine based on the mRNA platform up to six months following Omicron BA.1 breakthrough infection to trace the evolution of their antibody immunity.

26 Sep 2022

immunity News and Research

COVID-19 booster shots essential for maintaining long-term immunity against infection in older adults

Primary vaccinations and boosters effective in reducing COVID-19 severity during Delta and Omicron predominance

Study examines the incidence of severe COVID-19 in fully vaccinated and boosted high-risk populations

Significant humoral immune evasion contributes to the emergence and rapid spread of Arg346-mutated BA.4 and BA.5 sublineages

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Bile acids play an important role in regulating gut microbiome

How the gut microbiome could affect COVID-19 severity

Evolution of pathogens during vaccination programs

Some pre-existing conditions matter a lot more when assessing COVID-19 outcomes

How do clinical outcomes in patients infected with different Omicron subvariants differ?

Differences in protection from previous infection or vaccination against infection with Omicron BA.4/5 or BA.2

First data on Pfizer-BioNTech's Omicron BA.4/5 combination vaccine

Researchers uncover a new way the immune system detects coronavirus infection

Does leptin play a role in Parkinson’s disease?

In vitro gut models reveal how microplastics affect the GI tract

UTHSC professor receives $5 million to explore the gut as therapeutic target for treating disease

Study demonstrates how pan-sarbecovirus ORF7a protein plays a role in evading host immunity

Omicron BA.1 breakthrough infection in vaccinated individuals recall memory B cells to confer immunity

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