immunity News and Research

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Some healthcare workers vaccinated against COVID-19 show unexpectedly low responses to immunizations

A subset of healthcare workers vaccinated against COVID-19 had unexpectedly low responses to the immunizations, according to Cedars-Sinai investigators.

27 Oct 2022

How important is sterilizing immunity in protection against SARS-CoV-2?

The authors discussed the underlying principles of sterilizing immunity and its importance in protecting individuals against SARS-CoV-2 reinfections during the COVID-19 pandemic.

26 Oct 2022

25 years on, varicella vaccination reports impressive success in the USA

New research suggests that 25 years on, varicella vaccination continues to report impressive success in the USA.

26 Oct 2022

Omicron BA.4/BA.5 bivalent mRNA vaccine booster elicits similar neutralizing antibody responses to monovalent vaccine

Researchers analyzed the antibody response induced by the new bivalent mRNA SARS-CoV-2 vaccines in individuals who have been fully vaccinated with monovalent vaccines and those who have had breakthrough infection with the SARS-CoV-2 Omicron BA.4/BA.5 variants.

26 Oct 2022

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

Researchers analyzed the phenotypes of the SARS-CoV-2 variants of concern (VOCs), the molecular responses to infections from these VOCs, and the evolving virus-host interactions using a comparative genomic and proteomic approach.

26 Oct 2022

COVID-19 and the gut

Researchers summarize current knowledge about underlying mechanisms and potential therapeutic approaches for the effects of COVID-19 on the gut.

26 Oct 2022

A review of emerging pediatric respiratory viruses

Respiratory viruses continue to be a leading cause of childhood morbidity and mortality.

26 Oct 2022

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

A new approach to cancer immunotherapy that uses one type of immune cell to kill another - rather than directly attacking the cancer - provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.

25 Oct 2022

Researchers identify specific T cell required to bolster vaccine immunity against fungal pneumonia

Researchers at the University of Illinois College of Veterinary Medicine have demonstrated in a mouse model that a specific type of T cell, one of the body's potent immune defenses, produces cytokines that are necessary for the body to acquire immunity against fungal pathogens.

25 Oct 2022

Did COVID-19 mitigation measures in the United Kingdom impact the transmission of other infectious diseases?

Researchers explored the impact of the coronavirus disease 2019 (COVID-19) pandemic-associated non-pharmaceutical prevention measures on the transmission of 22 infectious diseases in England.

25 Oct 2022

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

Researchers designed a COVID-19 vaccine construct using hybrid SARS-CoV-2 S protein (containing SARS-CoV-2 Delta and Omicron variant mutations) and N protein peptides that confer T lymphocyte-mediated immune protection.

25 Oct 2022

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Researchers performed a longitudinal cohort study to assess the levels of immunoglobulins M (IgM), G (IgG), and A (IgA) against the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

24 Oct 2022

Study shows hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron sublineages

Researchers evaluated imprinted antibody responses against SARS-CoV-2 Omicron sublineages.

24 Oct 2022

COVID-19 vaccination during pregnancy protects infants from SARS-CoV-2 infection

In a recent study under review at the Nature Portfolio journal and currently posted to Research Square* preprint server, researchers evaluated the efficacy of maternal coronavirus disease 2019 (COVID-19) vaccination against infection of infants with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

24 Oct 2022

Antibody-mediated protection against symptomatic COVID achieved at low serum neutralizing titers

In a recent study posted to the medRxiv* preprint server, researchers in the United States assessed the efficiency of protection mediated by antibodies against symptomatic coronavirus disease 2019 (COVID-19) at low serum-neutralizing titers.

24 Oct 2022

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Researchers examine neutralizing antibody responses against SARS-CoV-2 in elderly individuals who received one mRNA booster dose.

23 Oct 2022

Fully vaccinated U.S. frontline workers may experience reduced severity, duration, and viral shedding during SARS-CoV-2

Researchers investigated the association between two or three doses of the messenger ribonucleic acid (mRNA) COVID-19 vaccine and viral loads and symptoms during infections with different SARS-CoV-2 variants.

23 Oct 2022

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

Researchers at Boston University made a chimeric recombinant SARS-CoV-2 encoding the spike glycoprotein gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate.

22 Oct 2022

The public health impact of the SARS-CoV-2 Omicron subvariant BA.5 relative to BA.2 in Denmark

Researchers conducted a nationwide study in Denmark to assess the public health impact of the SARS-CoV-2 Omicron subvariant BA.5 relative to BA.2.

22 Oct 2022

Modeling study suggests the possibility of Japanese encephalitis virus outbreak in Australia

A paper from a research team, which included mathematical modeling expertise from LSHTM and was led by the QIMR Berghofer Medical Research Institute in Brisbane, has suggested that up to 750,000 people across Australia could be at risk of exposure to Japanese encephalitis (JEV).

21 Oct 2022

immunity News and Research

Some healthcare workers vaccinated against COVID-19 show unexpectedly low responses to immunizations

How important is sterilizing immunity in protection against SARS-CoV-2?

25 years on, varicella vaccination reports impressive success in the USA

Omicron BA.4/BA.5 bivalent mRNA vaccine booster elicits similar neutralizing antibody responses to monovalent vaccine

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

COVID-19 and the gut

A review of emerging pediatric respiratory viruses

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

Researchers identify specific T cell required to bolster vaccine immunity against fungal pneumonia

Did COVID-19 mitigation measures in the United Kingdom impact the transmission of other infectious diseases?

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Study shows hybrid immunity or vaccine boosters elicit plasma neutralizing activity against Omicron sublineages

COVID-19 vaccination during pregnancy protects infants from SARS-CoV-2 infection

Antibody-mediated protection against symptomatic COVID achieved at low serum neutralizing titers

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Fully vaccinated U.S. frontline workers may experience reduced severity, duration, and viral shedding during SARS-CoV-2

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

The public health impact of the SARS-CoV-2 Omicron subvariant BA.5 relative to BA.2 in Denmark

Modeling study suggests the possibility of Japanese encephalitis virus outbreak in Australia

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