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Report reveals rising rates of fatal opioid overdoses in Ontario shelters

Researchers from the Ontario Drug Policy Research Network (ODPRN) at St. Michael's Hospital and Public Health Ontario analyzed health data from the Office of the Chief Coroner of Ontario and ICES, and found that there were 210 accidental opioid-related toxicity deaths within shelters between January 2018 to May 2022, with the number of deaths more than tripling during the study period (48 before the pandemic versus 162 during the pandemic).

18 Jun 2024

Enterprise Therapeutics appoints Dr Renu Gupta as Chief Medical Officer and Dr Janet Hammond as Non-Executive Director

Appointments bring additional respiratory and late clinical-stage drug development experience as Company commences Phase 2a clinical trial of its lead asset.

From Enterprise Therapeutics Ltd 17 Jun 2024

Global study confirms pantoprazole's role in reducing upper GI bleeding in the ICU

A widely available drug helps prevent upper gastrointestinal bleeding in critically ill adults on a breathing machine, according to the results of a global study and meta-analysis led by researchers at McMaster University.

14 Jun 2024

AI-driven alerts improve patient care escalation and survival rates in hospitals

Deploying and evaluating a machine learning intervention to improve clinical care and patient outcomes is a key step in moving clinical deterioration models from byte to bedside, according to a June 13 editorial in Critical Care Medicine that comments on a Mount Sinai study published in the same issue.

13 Jun 2024

Study advocates for liberal blood transfusions in TBI intensive care

Increased use of blood transfusions after major traumatic brain injury could help people hospitalized in intensive care units regain greater functional independence and a better quality of life.

13 Jun 2024

Noninvasive ventilation halves hypoxemia risk in emergency intubations: PREOXI trial findings

In current clinical care, most critically ill adults undergoing emergency tracheal intubation receive preoxygenation through an oxygen mask.

13 Jun 2024

Changing antibiotic delivery method improves sepsis outcomes globally

Changing the way antibiotics are given to adult patients with sepsis will save thousands of lives a year globally, according to research by The University of Queensland and The George Institute for Global Health.

12 Jun 2024

Climate change-related environmental stressors associated with increased CVD mortality

Cardiovascular disease (CVD) is the leading cause of death worldwide, accounting for approximately one in every three deaths, with more than 20 million deaths reported in 2021 according to a 2024 World Heart Federation report.

12 Jun 2024

Nasal microbiota composition predicts sepsis with high accuracy in ICU settings

The nasal microbiota of intensive care unit (ICU) patients effectively distinguishes sepsis from non-septic cases and outperforms analyzing the gut microbiota to predict sepsis, according to a new study published in Microbiology Spectrum, a journal of the American Society for Microbiology.

12 Jun 2024

Low-cost quality improvement program lowers mortality in El Salvador's pediatric ICU

Pediatric intensive care units (PICUs) in low and middle-income countries see elevated mortality rates, often 10 times higher than those in high-income countries.

12 Jun 2024

Precision medicine in sepsis care: Identifying and treating the PHES subgroup in children

Sepsis – the leading cause of mortality in children around the world – can present with a wide range of signs and symptoms, making a one-size-fits-all treatment strategy ineffective.

11 Jun 2024

Episodic hypoxemia from sleep apnea tied to increased lung cancer relapse

A new study to be presented at the SLEEP 2024 annual meeting is the first to find that episodic hypoxemia and hypoxic burden related to obstructive sleep apnea are associated with the risk of accelerated lung cancer reoccurrence.

4 Jun 2024

Machine learning could personalize oxygen levels for patients on ventilators

Supplemental oxygen is among the most widely prescribed therapies in the world, with an estimated 13 to 20 million patients worldwide requiring oxygen delivery by mechanical ventilation each year.

4 Jun 2024

Study challenges use of in-hospital mortality as sepsis quality metric for safety-net hospitals

Sepsis is a leading cause of death and disability and a key target of state and federal quality measures for hospitals.

31 May 2024

New consensus provides evidence-based guidelines for second-degree burns

Second-degree burns are among the most challenging injuries to manage due to their varying depths and healing potentials.

31 May 2024

Labor epidurals linked to lower risk of severe maternal morbidity

Having an epidural during labor is associated with a marked reduction in serious complications in the first few weeks after giving birth, finds a study published by The BMJ today.

22 May 2024

Study reveals low adoption of recommended smart inhaler therapy for asthma

Only 14.5 percent of adult patients with moderate or severe asthma are prescribed the recommended SMART combination inhaler regimen and over 40 percent of academic pulmonary and allergy clinicians have not adopted this optimal therapy, according to research published at the ATS 2024 International Conference.

21 May 2024

New tool may help identify newborns at highest risk for developing RSV lower respiratory tract infection

On the heels of a shortage of nirsevimab for infant respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) prevention, a new tool may help identify newborns at highest risk for developing serious RSV LRTI, according to research published at the ATS 2024 International Conference.

21 May 2024

Dupilumab shows promising results in Phase 3 trial for COPD with type 2 inflammation

Chronic obstructive pulmonary disease patients with type 2 inflammation may soon gain access to a new drug - dupilumab - that showed rapid and sustained improvements in patients in a pivotal Phase 3 clinical trial, researchers report in the New England Journal of Medicine.

20 May 2024

Study reveals increased risk of lung cancer in e-cigarette users after smoking cessation

Former cigarette smokers who use e-cigarettes or vaping devices may be at higher risk for lung cancer than those who don't vape, according to research published at the ATS 2024 International Conference.

20 May 2024

Critical Care News and Research

Report reveals rising rates of fatal opioid overdoses in Ontario shelters

Enterprise Therapeutics appoints Dr Renu Gupta as Chief Medical Officer and Dr Janet Hammond as Non-Executive Director

Global study confirms pantoprazole's role in reducing upper GI bleeding in the ICU

AI-driven alerts improve patient care escalation and survival rates in hospitals

Study advocates for liberal blood transfusions in TBI intensive care

Noninvasive ventilation halves hypoxemia risk in emergency intubations: PREOXI trial findings

Changing antibiotic delivery method improves sepsis outcomes globally

Climate change-related environmental stressors associated with increased CVD mortality

Nasal microbiota composition predicts sepsis with high accuracy in ICU settings

Low-cost quality improvement program lowers mortality in El Salvador's pediatric ICU

Precision medicine in sepsis care: Identifying and treating the PHES subgroup in children

Episodic hypoxemia from sleep apnea tied to increased lung cancer relapse

Machine learning could personalize oxygen levels for patients on ventilators

Study challenges use of in-hospital mortality as sepsis quality metric for safety-net hospitals

New consensus provides evidence-based guidelines for second-degree burns

Labor epidurals linked to lower risk of severe maternal morbidity

Study reveals low adoption of recommended smart inhaler therapy for asthma

New tool may help identify newborns at highest risk for developing RSV lower respiratory tract infection

Dupilumab shows promising results in Phase 3 trial for COPD with type 2 inflammation

Study reveals increased risk of lung cancer in e-cigarette users after smoking cessation

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