Cytoplasm News and Research

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NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

A new study explores the role of non-structural protein 1 (NSP1) in SARS-CoV-2 infection and pathogenesis.

16 Jun 2022

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

In a recent study posted to the bioRxiv* pre-print server, researchers illustrated the cryo-electron microscopic (cryo-EM) structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein in lipid nanodiscs to 3.5 angstroms (Å) resolution.

16 Jun 2022

Deciphering the structure of nuclear pore complex piece by piece

Whatever you are doing, whether it is driving a car, going for a jog, or even at your laziest, eating chips and watching TV on the couch, there is an entire suite of molecular machinery inside each of your cells hard at work.

10 Jun 2022

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Using advanced microscopy techniques, researchers at Karolinska Institutet and Stockholm University in Sweden have visualized in unprecedented detail the machinery that the cells' powerhouses, the mitochondria, use to form their proteins.

8 Jun 2022

Gastrointestinal complications caused by SARS-CoV-2

scientists discuss the gastrointestinal complications associated with COVID-19.

7 Jun 2022

Phase separation discovery could lead to new interventions to regulate immune activity

Protein complexes that play a critical role in launching an immune response assemble in droplets that form within the liquid environment in cells much like oil droplets in water, UT Southwestern scientists report in a new study.

6 Jun 2022

Persistence of viral RNA following acute infection

Professor Diane Griffin from the Johns Hopkins Bloomberg School of Public Health, USA, has recently explained the persistence mechanism of viral RNA in the human body after clinical recovery from acute infection.

6 Jun 2022

New findings reveal potential mechanisms for cellular defects in human laminopathies

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the Proceedings of the National Academy of Sciences.

1 Jun 2022

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Researchers profiled the binding sites of the entire SARS-CoV-2 spike protein sequence.

26 May 2022

Scientists discover a gene defect that results in allergic and autoimmune disease

Inflammation of the skin and the esophagus, food allergy and asthma are just some of the symptoms of a now 12-year-old boy who was the first to have a mutation on the IL-33 gene. An international team led by a physician from the Karl Landsteiner University for Health Sciences, Krems, discovered this new disease entity.

26 May 2022

Deep visual proteomics is redefining cancer diagnostics

In a recent study published in the journal Nature Biotechnology, researchers introduced deep visual proteomics (DVP), an amalgamation of artificial intelligence (AI) for image analysis and mass spectrometry (MS) for proteomic profiling of biological samples.

22 May 2022

Evaluating serum levels of S100A9 as an inflammatory marker of unfavorable outcomes in patients with COVID-19

Investigators demonstrated S100A9 as an inflammatory biomarker among hospitalized SARS-CoV-2 patients.

20 May 2022

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Researchers investigated COVID-19-triggered changes in the levels of cyclins and cyclin-dependent kinases inside host cells.

10 May 2022

Study investigates stress granule formation during infection with the human common cold coronavirus and SARS-CoV-2

Researchers analyzed the inhibition of stress granules formation in cells infected by the human common cold coronavirus HCOV-OC43 and SARS-CoV-2.

5 May 2022

Bacteria-mediated oral delivery of viral replicon-based mRNA vaccines

Scientists have discussed the possibilities of developing oral replicon-based mRNA vaccines against SARS-CoV-2.

4 May 2022

Study explores SARS-CoV-2 RNA genome's functional interactions with host cell

In a new study, a worldwide map of the SARS-CoV-2 genome-associated host proteins was developed by a team of researchers using the identification of RNA-binding protein by MS (ChIRP-MS) technique.

3 May 2022

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

Researchers assessed the binding pocket of linoleic acid, an essential free-fatty acid in the receptor-binding domains of the spike protein of beta-coronaviruses.

26 Apr 2022

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

My work is focused on looking at the dynamics of B/T cell populations within lymph nodes from patients that had recovered from COVID-19. My role in this research was developing and implementing microscopy image analysis techniques using methods and instrumentation in part supplied by TissueGnostics.

From TissueGnostics 26 Apr 2022

Study suggests SARS-CoV-2 is undergoing evolutionary changes at the functional RNA level in addition to the amino acid level

Researchers demonstrated SARS-CoV-2 evolution at the transcriptional level.

22 Apr 2022

CryoEM reveals never-before-seen details of the human androgen receptor

Scientists at Memorial Sloan Kettering Cancer Center (MSK) have glimpsed never-before-seen details of the human androgen receptor - the protein inside of cells that responds to male-typical hormones like testosterone.

20 Apr 2022