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Newer class of diabetes medications may also improve cardiovascular health, researchers report

A newer class of medications used to control blood sugar levels in type 2 diabetics may also improve cardiovascular health, researchers from The Ohio State University Wexner Medical Center reported in a new meta-analysis presented yesterday at the American Society of Hypertension's Annual Scientific Meeting and Exposition.

17 May 2013

Protein processing breakdown in endoplasmic reticulum

With obesity reaching epidemic levels in some parts of the world, scientists have only begun to understand why it is such a persistent condition. A study in the Journal of Biological Chemistry adds substantially to the story by reporting the discovery of a molecular chain of events in the brains of obese rats that undermined their ability to suppress appetite and to increase calorie burning.

17 May 2013

Study reveals that prolonged Dkk1 signaling can lead to fibrosis, stiffening of artery walls

The hardening of arteries is a hallmark of atherosclerosis, an often deadly disease in which plaques, excessive connective tissue, and other changes build up inside vessel walls and squeeze off the flow of oxygen-rich blood throughout the body.

17 May 2013

Tel Aviv University researchers invent a method for repairing damaged peripheral nerves

Some parts of the body, like the liver, can regenerate themselves after damage. But others, such as our nervous system, are considered either irreparable or slow to recover, leaving thousands with a lifetime of pain, limited mobility, or even paralysis.

14 May 2013

Researchers discover potential treatment for deadly, drug-resistant bacterial infections

Through the serendipity of science, researchers at the University of Pittsburgh have discovered a potential treatment for deadly, drug-resistant bacterial infections that uses the same approach that HIV uses to infect cells.

8 May 2013

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Aileron Therapeutics, Inc. today announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.

7 May 2013

EPAC2 and diabetes: an interview with Dr. Hussain, Johns Hopkins University

EPAC stands for exchange protein activated by cyclic AMP (cAMP). cAMP is an (among many) intracellular messenger molecule. cAMP is generated when certain hormones stimulate a cell by binding to their receptor, which is at the outside surface of the cell.

3 May 2013

Pancreatitis and diabetes drugs: an interview with Dr Sonal Singh, Johns Hopkins University School of Medicine

Acute pancreatitis is an inflammation of the pancreas which leads to leakage of pancreatic enzymes. Apart from certain drugs such as GLP-1 based therapies, the most common causes of pancreatitis are Gallstones and Alcohol use.

30 Apr 2013

Neuroscientists identify cellular change in the brain that accompanies obesity

A team of American and Italian neuroscientists has identified a cellular change in the brain that accompanies obesity. The findings could explain the body's tendency to maintain undesirable weight levels, rather than an ideal weight, and identify possible targets for pharmacological efforts to address obesity.

30 Apr 2013

Maruishi gains exclusive rights to develop, commercialize Cara Therapeutics' CR845 in Japan

Cara Therapeutics, Inc. and Maruishi Pharmaceutical Company, Ltd. today announced that they have entered into a License Agreement providing Maruishi with exclusive rights to develop, manufacture and commercialize Cara's lead analgesic drug candidate, CR845, for acute pain and uremic pruritus in Japan.

29 Apr 2013

Shin Poong to develop, market Almac Discovery's ALM201 in South Korea

Almac Discovery today announced the licensing of its novel anti-angiogenic peptide ALM201 to Shin Poong Pharmaceutical Company Ltd for clinical development and marketing in South Korea.

29 Apr 2013

BIOMARGIN research project aims to prevent, diagnose lesions in transplanted kidneys

The BIOMARGIN (BIOMArkers of Renal Graft INjuries in kidney allograft recipients) research project, coordinated by INSERM, has just received financing from the "health" seventh framework programme of the European Commission to the tune of 6 million euros for a four-year period.

29 Apr 2013

Genes play role in wound healing, regulate biological processes in human skin

Biologists at UC San Diego have identified eight genes never before suspected to play a role in wound healing that are called into action near the areas where wounds occur.

26 Apr 2013

Immudex signs agreement to provide MHC-peptide multimer and Elispot proficiency panel services

Immudex has entered into a strategic agreement with the US Cancer Immunotherapy Consortium (CIC) of the Cancer Research Institute, and the European Association for Cancer Immunotherapy (CIMT), under which Immudex will provide MHC-peptide multimer and Elispot proficiency panel services worldwide.

26 Apr 2013

Urine tests could improve diagnosis of liver cancer

New data from two clinical trials presented today at the International Liver Congress- 2013 demonstrate substantial improvements in the detection of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) using diagnostic urine tests.

26 Apr 2013

Serum C-peptide levels predict cardiovascular death risk

Levels of C-peptide predict the risk for death from cardiovascular disease in nondiabetic adults, show data from the US National Health and Nutrition Examination Survey.

25 Apr 2013

Individual hydroxymethylcytosine molecules in DNA detected by new method involving chemical modification and nanopore analysis

Changes in the bases that make up DNA act as markers, telling a cell which genes it should read and which it shouldn’t. In the journal Angewandte Chemie, a British team has now introduced a new method that makes it possible to enrich the rare gene segments that contain the modified base hydroxymethylcytosine and to identify individual hydroxymethylcytosine molecules in DNA. Such modifications are associated with autoimmune diseases and cancer.

24 Apr 2013

Rheumatoid arthritis diagnosis: an interview with Dr. Stan Naides, Medical Director, Quest Diagnostics

Rheumatoid arthritis (RA) is an autoimmune disorder that can cause debilitating joint damage. In cases of RA, the immune system attacks the body’s own tissues, especially the membranes that line the joints. As a result, fluid builds up in the joints, causing pain and systemic inflammation, leading to joint destruction if untreated.

From Quest Diagnostics 23 Apr 2013

Theradiag obtains CE mark for proprietary anti-CCP IVD kit in rheumatoid arthritis

Theradiag, a company specializing in theranostic and in vitro diagnostics, today announced it has obtained a CE mark for its proprietary anti-CCP in vitro diagnostic kit in rheumatoid arthritis.

23 Apr 2013

Pergamum reaches LPLV in Phase I/II trial of LL-37 for treatment of hard-to-heal venous leg ulcers

Pergamum AB announced today that the company has reached last-patient-last-visit in a randomized Phase I/II trial of LL-37 for the treatment of hard-to-heal venous leg ulcers. Karolinska Development AB is the majority owner of Pergamum.

23 Apr 2013

Peptides News and Research

Newer class of diabetes medications may also improve cardiovascular health, researchers report

Protein processing breakdown in endoplasmic reticulum

Study reveals that prolonged Dkk1 signaling can lead to fibrosis, stiffening of artery walls

Tel Aviv University researchers invent a method for repairing damaged peripheral nerves

Researchers discover potential treatment for deadly, drug-resistant bacterial infections

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

EPAC2 and diabetes: an interview with Dr. Hussain, Johns Hopkins University

Pancreatitis and diabetes drugs: an interview with Dr Sonal Singh, Johns Hopkins University School of Medicine

Neuroscientists identify cellular change in the brain that accompanies obesity

Maruishi gains exclusive rights to develop, commercialize Cara Therapeutics' CR845 in Japan

Shin Poong to develop, market Almac Discovery's ALM201 in South Korea

BIOMARGIN research project aims to prevent, diagnose lesions in transplanted kidneys

Genes play role in wound healing, regulate biological processes in human skin

Immudex signs agreement to provide MHC-peptide multimer and Elispot proficiency panel services

Urine tests could improve diagnosis of liver cancer

Serum C-peptide levels predict cardiovascular death risk

Individual hydroxymethylcytosine molecules in DNA detected by new method involving chemical modification and nanopore analysis

Rheumatoid arthritis diagnosis: an interview with Dr. Stan Naides, Medical Director, Quest Diagnostics

Theradiag obtains CE mark for proprietary anti-CCP IVD kit in rheumatoid arthritis

Pergamum reaches LPLV in Phase I/II trial of LL-37 for treatment of hard-to-heal venous leg ulcers

Editorial Focus eBook - Peptides and Oligonucleotides (2nd edition) eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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