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New type of immunotherapy extends survival of mice with triple negative breast tumors

Immunotherapies for cancer - treatments that prime the immune system to attack tumors - are valuable weapons in the anti-cancer arsenal. But some cancers are more difficult to target with this strategy than others.

17 Aug 2020

Potential inhibitors of SARS-CoV-2 identified

Now, a new study published on the preprint server bioRxiv in August 2020 reports the discovery of two inhibitors of the helicase enzyme, which is essential for viral replication and the most highly conserved non-structural coronavirus (CoV) protein.

16 Aug 2020

SARS-CoV-2 spike pocket is a putative target for antiviral design

In a methodologically rigorous study, researchers from the University of Oxford have recently shown how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein harbors a lipid-binding pocket which modulates the stability of the prefusion trimer and provides conformational shielding from antibodies. Their findings are currently freely available on the bioRxiv* preprint server.

16 Aug 2020

Influenza-virus-based vaccine platform another viable option against SARS-CoV-2

In a novel proof of concept study, published on the bioRxiv preprint server, U.S. researchers used attenuated influenza viral particles that express severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain to induce neutralizing antibodies in mice – unveiling another viable vaccine candidate for preventing coronavirus disease (COVID-19).

14 Aug 2020

Natural controllers shed light on immunity mechanisms against hepatitis B

Infections in humans caused by the hepatitis B virus (HBV) represent a major public health problem. Despite the availability of effective protective vaccines, more than 250 million individuals worldwide are chronically infected according to WHO estimates.

13 Aug 2020

Membrane nanoparticles acts as a bait to trap SARS-CoV-2

In an exciting new bioRxiv preprint research paper, Chinese researchers describe the development of membrane nanoparticles from ACE2-rich cells with a potent capacity to block the adherence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Aug 2020

Australian researcher receives Campbell Foundation's grant to study HIV prevention methods

The Campbell Foundation, a Fort Lauderdale-based nonprofit that provides grants to support alternative clinical approaches to the treatment and prevention of HIV/AIDS, has awarded an $85,000 grant to Gilda Tachedjian, PhD., Head of Life Sciences and Principal Investigator at Burnet Institute in Melbourne, Australia.

13 Aug 2020

SPT enzyme can be used as metabolically responsive “switch” to slow tumor growth

The enzyme serine palmitoyl-transferase can be used as a metabolically responsive "switch" that decreases tumor growth, according to a new study by a team of San Diego scientists, who published their findings Aug. 12 in the journal Nature.

12 Aug 2020

SUTD scientists use 3D printing to create heart cells from stem cells

All humans start out from a single cell which then divides to eventually form the embryo. Depending on the signals sent by their adjacent cells, these divided cells are then developed or differentiated into specific tissues or organs.

11 Aug 2020

Researchers discover dose threshold that improves delivery of cancer-fighting drugs into a tumor

University of Toronto Engineering researchers have discovered a dose threshold that greatly increases the delivery of cancer-fighting drugs into a tumor.

11 Aug 2020

Oxytocin can aid in the control and prevention of osteoporosis

Oxytocin, produced by the hypothalamus and sometimes known as the "love hormone" for its involvement in pair bonding and orgasm, can be a strong ally in the control and prevention of osteoporosis, according to a study by scientists at São Paulo State University in Brazil.

10 Aug 2020

Study suggests novel strategy to slow down evolution of antibiotic resistance

The rise of antibiotic resistance in many pathogens has been driven by the spread of a small number of strains, suggesting that some bacteria may be genetically pre-disposed to evolving resistance.

10 Aug 2020

Scientists find new way of identifying and targeting hidden HIV viral reservoirs during ART therapy

Scientists at The Wistar Institute may have discovered a new way of identifying and targeting hidden HIV viral reservoirs during treatment with antiretroviral therapy (ART).

7 Aug 2020

Method provides new insight into brain cells that maintain body's master circadian clock.

UT Southwestern scientists have developed a genetically engineered mouse and imaging system that lets them visualize fluctuations in the circadian clocks of cell types in mice.

7 Aug 2020

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed.

7 Aug 2020

Study: Drinking honeysuckle decoction accelerates the negative conversion of COVID-19 patients

In a new study in Cell Discovery, Chen-Yu Zhang's group at Nanjing University and two other groups from Wuhan Institute of Virology and the Second Hospital of Nanjing present a novel finding that absorbed miRNA MIR2911 in honeysuckle decoction (HD) can directly target SARS-CoV-2 genes and inhibit viral replication. Drinking of HD accelerate the negative conversion of COVID-19 patients.

7 Aug 2020

HDAC6 inhibitors increase efficacy of immunotherapy in triple-negative breast cancer

Genetic modifier HDAC6 was found to control tumor growth and halt metastasis in triple-negative breast cancer in vivo, according to a new study published in the top-tier journal Cancer Research by investigators at the George Washington University (GW) Cancer Center.

6 Aug 2020

in vivo News and Research

New type of immunotherapy extends survival of mice with triple negative breast tumors

Potential inhibitors of SARS-CoV-2 identified

SARS-CoV-2 spike pocket is a putative target for antiviral design

Influenza-virus-based vaccine platform another viable option against SARS-CoV-2

Natural controllers shed light on immunity mechanisms against hepatitis B

Membrane nanoparticles acts as a bait to trap SARS-CoV-2

Australian researcher receives Campbell Foundation's grant to study HIV prevention methods

SPT enzyme can be used as metabolically responsive “switch” to slow tumor growth

SUTD scientists use 3D printing to create heart cells from stem cells

Researchers discover dose threshold that improves delivery of cancer-fighting drugs into a tumor

Oxytocin can aid in the control and prevention of osteoporosis

Study suggests novel strategy to slow down evolution of antibiotic resistance

Scientists find new way of identifying and targeting hidden HIV viral reservoirs during ART therapy

Method provides new insight into brain cells that maintain body's master circadian clock.

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

Study: Drinking honeysuckle decoction accelerates the negative conversion of COVID-19 patients

HDAC6 inhibitors increase efficacy of immunotherapy in triple-negative breast cancer

Researchers investigate why irregular heartbeats occur after stem cell transplantation

Regeneron antibody cocktail shows promise as potential COVID-19 treatment

Researchers develop scalable strategy to find novel molecular glue degraders

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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