Clinical Trial News and Research

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Researchers take step toward developing cell therapy treatment for MS

An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.

27 Nov 2023

Abiomed announces enrollment of first patient in landmark RECOVER IV trial for AMI cardiogenic shock

Abiomed, part of Johnson & Johnson MedTech, announces the first patient in the world has been enrolled in the landmark RECOVER IV randomized controlled trial (RCT).

27 Nov 2023

Researchers identify biomarkers for checkpoint inhibitor-induced hyperprogression of melanoma cells

Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system to fight them.

24 Nov 2023

Gene therapy could reverse symptoms of rare, hereditary DOOR syndrome

A lot of research has been done over many decades on diseases that are widespread in large parts of the population, such as cancer and heart disease. As a result, treatment methods have improved enormously thanks to long-term research efforts on diseases that affect many people.

23 Nov 2023

Half-dose COVID-19 booster elicits similar immune response with fewer side effects

Reducing the dose of a widely used COVID-19 booster vaccine produces a similar immune response in adults to a full-dose with fewer side effects, according to a new study.

23 Nov 2023

Numbing agent lidocaine may have cancer-fighting properties

Lidocaine - often used as numbing agent for outpatient medical procedures - activates certain bitter taste receptors through two unique mechanisms that result in cancer cell death, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.

22 Nov 2023

Acoustic stimulation of the brain may ease persistent symptoms after mild traumatic brain injury

New research indicates that acoustic stimulation of the brain may ease persistent symptoms in individuals who experienced mild traumatic brain injury in the past.

22 Nov 2023

Study finds among outpatients with mild to moderate COVID-19, treatment with fluvoxamine does not reduce duration of symptoms

Researchers investigate the effects of high-dose fluvoxamine among patients with mild-to-moderate COVID-19.

22 Nov 2023

Study shows how probiotic Bifidobacteria longum can help relieve constipation

Scientists have identified the genes in the probiotic Bifidobacteria longum responsible for improving gut motility.

21 Nov 2023

Drug for children with achondroplasia may help reduce chances of SIDS

A drug that boosts bone growth in children with the most common form of dwarfism, may also reduce their chances of sudden infant death syndrome, sleep apnea and needing surgery, according to a new study.

21 Nov 2023

Immunotherapy drug is safe and may benefit overall survival for patients with advanced NSCLC

For patients with advanced or metastatic non-small cell lung cancer (NSCLC) and limited performance status, an immune checkpoint inhibitor drug called durvalumab is safe and may benefit overall survival, according to a new eClinicalMedicine study by UPMC Hillman Cancer Center researchers.

21 Nov 2023

PROFID EHRA trial aims to personalize the prevention of sudden cardiac death after myocardial infarction

The first clinical trial to challenge the routine implantation of a defibrillator in myocardial infarction survivors with heart failure has enrolled its first patient.

21 Nov 2023

Call for improved data sharing practices in the pharmaceutical industry

Development of potential or improved anti-cancer treatments are being blocked or slowed down by lack of transparency in data sharing between pharmaceutical companies and research groups, according to cancer clinicians, researchers and consumers.

21 Nov 2023

Nut consumption linked to improved male fertility, systematic review reveals

A systematic review finds that consuming at least 60 grams of nuts daily significantly enhances male fertility by improving sperm vitality, motility, and morphology, while evidence for nut consumption's impact on female fertility remains limited.

20 Nov 2023

Young people may be more susceptible to the effects of elevated blood cholesterol and hypertension

Young people may be more susceptible to the effects of the risk factors for developing atherosclerosis. According to a study carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), younger people are especially vulnerable to the damaging effects of elevated blood cholesterol and hypertension, two of the major modifiable cardiovascular risk factors.

20 Nov 2023

New study unravels the mystery of red wine headaches

A red wine may pair nicely with the upcoming Thanksgiving meal. But for some people, drinking red wine even in small amounts causes a headache.

20 Nov 2023

Breakthroughs in TB prevention offer hope for children

Taking a common antibiotic could more than half the risk of children becoming sick with multidrug resistant tuberculosis (MDR-TB), according to findings presented this week at a conference on lung health.

20 Nov 2023

Academic medical centers may help mitigate structural racism in cardiovascular care for Black women

Investigators from the Barbra Streisand Women’s Heart Center in the Smidt Heart Institute at Cedars-Sinai have found that among a cohort of women with obstructive coronary artery disease treated at academic medical centers, racial and ethnic disparities did not impact their long-term outcomes.

20 Nov 2023

What are the minimal clinically important differences in the Diabetes Distress Scale–17 and its four subscales?

Adistribution-based minimal clinically important difference (MCID) for the Diabetes Distress Scale–17 (DDS-17) and its four subscales.

20 Nov 2023

Breakthrough in tuberculosis treatment: TB-PRACTECAL trial reveals efficacy of new oral regimen

The TB-PRACTECAL clinical trial outcomes, which evaluated the efficacy and safety of oral bedaquiline.

20 Nov 2023

Clinical Trial News and Research

Researchers take step toward developing cell therapy treatment for MS

Abiomed announces enrollment of first patient in landmark RECOVER IV trial for AMI cardiogenic shock

Researchers identify biomarkers for checkpoint inhibitor-induced hyperprogression of melanoma cells

Gene therapy could reverse symptoms of rare, hereditary DOOR syndrome

Half-dose COVID-19 booster elicits similar immune response with fewer side effects

Numbing agent lidocaine may have cancer-fighting properties

Acoustic stimulation of the brain may ease persistent symptoms after mild traumatic brain injury

Study finds among outpatients with mild to moderate COVID-19, treatment with fluvoxamine does not reduce duration of symptoms

Study shows how probiotic Bifidobacteria longum can help relieve constipation

Drug for children with achondroplasia may help reduce chances of SIDS

Immunotherapy drug is safe and may benefit overall survival for patients with advanced NSCLC

PROFID EHRA trial aims to personalize the prevention of sudden cardiac death after myocardial infarction

Call for improved data sharing practices in the pharmaceutical industry

Nut consumption linked to improved male fertility, systematic review reveals

Young people may be more susceptible to the effects of elevated blood cholesterol and hypertension

New study unravels the mystery of red wine headaches

Breakthroughs in TB prevention offer hope for children

Academic medical centers may help mitigate structural racism in cardiovascular care for Black women

What are the minimal clinically important differences in the Diabetes Distress Scale–17 and its four subscales?

Breakthrough in tuberculosis treatment: TB-PRACTECAL trial reveals efficacy of new oral regimen

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