Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Professor Hawking to open inaugural Cambridge Rare Disease Summit on 14 September, 2015

Professor Hawking was famously diagnosed with the rare motor neuron disease at 21, and was told science had no answers. He has of course gone on to live a long and productive life, and the Cambridge Rare Disease Summit will discuss how to make this a reality for the 3.5 million other Britons who live with a rare disease.

11 Sep 2015

Worldwide Protein Data Bank symposium focuses on multi-scale structural biology

The symposium titled with "Integrative Structural Biology with Hybrid Methods" is held focusing on the multi-scale structural biology, which aims to analyze structures of protein molecules and their assemblies, cellular machines, organelle, and even living cells and organisms by the hybrid methods, integrating many different technologies, such as chemical cross-links, MS spectrometry, FRET, Super-resolution microscopy, X-ray diffraction, NMR, and Computer modeling, in addition to Cryo-electron microscopy that has been attracting much attention these days.

10 Sep 2015

Scientists identify new drug target to treat heart arrhythmias

Scientists at The Ohio State University Davis Heart and Lung Research Institute have identified a new target they hope will help make the next drug discovery for patients suffering from heart arrhythmias happen sooner.

9 Sep 2015

Three drug-like compounds may offer better odds of survival to patients with prostate cancer, find SMU researchers

Researchers at Southern Methodist University, Dallas, have discovered three new drug-like compounds that could ultimately offer better odds of survival to prostate cancer patients.

9 Sep 2015

DNDi announces successful completion of SCYX-7158 Phase I study for treatment of sleeping sickness

The Drugs for Neglected Diseases initiative (DNDi) has announced today at the 9th European Congress on Tropical Medicine and International Health in Basel, Switzerland, the successful completion of Phase I human clinical trials for SCYX-7158 (AN5568), the first oral drug candidate specifically developed from the earliest drug discovery stage to combat human African trypanosomiasis, or sleeping sickness, a deadly parasitic disease transmitted by the tsetse fly.

9 Sep 2015

Assay plates: selecting the correct product

Correct assay plate selection is vital for successful research, whether you are performing absorbance, fluorescence or luminescence assays. Porvair Sciences offers a wide range of assay plates which are recognized as industry-leading tools for Pharma drug discovery and screening.

2 Sep 2015

Researchers successfully use alcohols as reagents in alkylation reaction

Researchers at Princeton have developed a dual catalyst system that directly installs alkyl groups--fragments containing singly bonded carbon and hydrogen atoms that have extremely useful properties for drug discovery--onto compounds called heteroarenes. The new reaction uses simple and abundant alcohols and offers a milder and more widely applicable alternative to existing strategies.

28 Aug 2015

Dr. Sharma receives research award from ASCO to continue study on triple-negative breast cancer

Dr. Sharma was awarded the 2015 Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology to continue her research on triple-negative breast cancer.

25 Aug 2015

European chestnut leaves contain ingredients with power to disarm deadly staph bacteria

Leaves of the European chestnut tree contain ingredients with the power to disarm dangerous staph bacteria without boosting its drug resistance, scientists have found.

24 Aug 2015

New ASU-POSTECH collaboration aims to discover biological molecules for health care, renewable energy research

The Biodesign Institute at Arizona State University and Pohang University of Science and Technology (POSTECH), Pohang, South Korea, have announced a partnership that will catalyze discoveries with a major impact on health care and clean energy applications.

24 Aug 2015

Janus collaborates with Roche to develop TLR inhibitor to address several autoimmune diseases

Janus Biotherapeutics today announced that they have entered into a collaboration with Roche for the development of a small molecule toll-like receptor (TLR) inhibitor with the potential to address several autoimmune diseases. TLRs are an important class of proteins that play a key role in the innate immune system.

20 Aug 2015

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Synthorx Inc. announced today that the company has employed its proprietary protein expression system to successfully produce proteins containing novel amino acids. Using a semi-synthetic DNA template (containing the synthetic base pair X and Y), Synthorx scientists were able to produce RNA containing X and Y, which was used with an otherwise fully natural biological system, to efficiently direct the incorporation of multiple novel amino acids at different sites in proteins.

19 Aug 2015

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

In experiments with 500,000 genetically engineered zebrafish embryos, Johns Hopkins scientists report they have developed a potentially better and more accurate way to screen for useful drugs, and they have used it to identify 24 drug candidates that increase the number of insulin-producing cells in the pancreas.

19 Aug 2015

ADDF establishes Goodes Prize to recognize scientists in Alzheimer's drug discovery research

Thanks to the generosity of former Warner-Lambert CEO and Chairman Melvin R. Goodes and his family, the Alzheimer's Drug Discovery Foundation has established the only prize specifically recognizing scientists in Alzheimer's drug discovery research. Mr. Goodes—who has been open about his own Alzheimer's diagnosis—is an honorary member of the ADDF's Board of Governors.

13 Aug 2015

New TSRI discovery could open way to incorporate sulfur into natural antibiotic products

In a discovery with implications for future drug design, scientists from the Florida campus of The Scripps Research Institute have shown an unprecedented mechanism for how a natural antibiotic with antitumor properties incorporates sulfur into its molecular structure, an essential ingredient of its antitumor activity.

11 Aug 2015

UBC researchers identify gene that could be important cause of obesity

Scientists at the University of British Columbia have discovered a gene that could be an important cause of obesity.

11 Aug 2015

Newcastle University awarded £5M for drug development research

Cancer Research UK's Drug Discovery Committee has today (Friday) awarded Newcastle University's Northern Institute of Cancer Research £5M to bring more cancer drugs to clinical trials.

7 Aug 2015

Heptares, AstraZeneca sign licensing agreement to develop and commercialise immuno-oncology treatments

Heptares Therapeutics, the clinical-stage GPCR structure-guided drug discovery and development company and wholly-owned subsidiary of Sosei Group Corporation, is pleased to announce that it has entered into a licensing agreement with AstraZeneca under which AstraZeneca will acquire exclusive global rights to develop, manufacture and commercialise the adenosine A2A receptor antagonist, HTL-1071, a small molecule immuno-oncology candidate, and potential additional A2A receptor-blocking compounds.

6 Aug 2015

Laser autofocus option added to BioTek’s Cytation Cell Imaging Multi-Mode Readers

BioTek’s award-winning Cytation Cell Imaging Multi-Mode Readers now have an option for laser autofocus, along with the current image-based autofocus method.

4 Aug 2015

G7 Therapeutics, MorphoSys collaborate on novel antibody therapeutics targeting GPCRs and ion channels

MorphoSys AG and G7 Therapeutics AG announced today that they have signed an agreement to collaborate on novel antibody therapeutics targeting G protein-coupled receptors and potentially other disease-related transmembrane proteins such as ion channels.

4 Aug 2015

Drug Discovery News and Research

Further Reading

Professor Hawking to open inaugural Cambridge Rare Disease Summit on 14 September, 2015

Worldwide Protein Data Bank symposium focuses on multi-scale structural biology

Scientists identify new drug target to treat heart arrhythmias

Three drug-like compounds may offer better odds of survival to patients with prostate cancer, find SMU researchers

DNDi announces successful completion of SCYX-7158 Phase I study for treatment of sleeping sickness

Assay plates: selecting the correct product

Researchers successfully use alcohols as reagents in alkylation reaction

Dr. Sharma receives research award from ASCO to continue study on triple-negative breast cancer

European chestnut leaves contain ingredients with power to disarm deadly staph bacteria

New ASU-POSTECH collaboration aims to discover biological molecules for health care, renewable energy research

Janus collaborates with Roche to develop TLR inhibitor to address several autoimmune diseases

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

ADDF establishes Goodes Prize to recognize scientists in Alzheimer's drug discovery research

New TSRI discovery could open way to incorporate sulfur into natural antibiotic products

UBC researchers identify gene that could be important cause of obesity

Newcastle University awarded £5M for drug development research

Heptares, AstraZeneca sign licensing agreement to develop and commercialise immuno-oncology treatments

Laser autofocus option added to BioTek’s Cytation Cell Imaging Multi-Mode Readers

G7 Therapeutics, MorphoSys collaborate on novel antibody therapeutics targeting GPCRs and ion channels

Pharmaron’s drug conjugates platform from idea to XDC eBook

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo