Immune System News and Research

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Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.

2 Jan 2024

How immune cells shape our earliest breaths

Study profiles the development of immune cells in human lungs during embryonic and fetal stages, revealing their influence on epithelial cell fate and lung development.

1 Jan 2024

Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency

This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell response during acute infection model.

29 Dec 2023

Next-gen sequencing identifies thousands of cancer patients missing out on immunotherapy

Brigham researchers' findings from next-generation sequencing suggest that revising current cancer care guidelines could allow approximately 6,000 more patients in the U.S. to benefit from immunotherapy treatment each year

28 Dec 2023

New model links RNA editing glitch to early-stage type 1 diabetes

Hebrew University study proposes a new model suggesting that disrupted RNA editing within pancreatic beta cells might initiate an inflammatory response akin to early-stage type 1 diabetes.

26 Dec 2023

Spatial profiling predicts recurrence of Hodgkin lymphoma after bone marrow transplant

Cedars-Sinai Cancer investigators have discovered a new way to predict whether a cancer of the immune system will recur in patients treated with a bone marrow transplant.

22 Dec 2023

Previously unrecognized class of antibodies can broadly neutralize multiple virus strains

Researchers have identified a previously unrecognized class of antibodies - immune system proteins that protect against disease - that appear capable of neutralizing multiple forms of flu virus.

21 Dec 2023

R21/Matrix-M vaccine gets WHO green light for global rollout

The R21/Matrix-M™ malaria vaccine is one step closer to mass rollout, after officially receiving WHO prequalification status, making it eligible for procurement by United Nations agencies.

21 Dec 2023

Unraveling nuanced roles of JAK inhibitors in inflammation

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues.

21 Dec 2023

Scientists develop a method for tracking cellular events over time in living organisms

While physicists continue to argue about whether time is indeed an illusion, as Albert Einstein claimed, biologists have no doubt about its significance for understanding life as a dynamic system.

21 Dec 2023

UKHSA and ONS publish latest Winter CIS data

The Winter CIS was launched jointly by the UK Health Security Agency (UKHSA) and the Office for National Statistics (ONS) in November 2023 to deliver real-time prevalence and positivity data to aid the surveillance of COVID-19 in the community and help understand the winter pressures on the NHS.

21 Dec 2023

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Despite their promise, immunotherapies fail to treat many cancers, including over 80% of some of the most advanced breast cancers.

20 Dec 2023

Brazilian researchers create cutting-edge nanoparticle weapon against tuberculosis

A low-cost technology involving nanoparticles loaded with antibiotics and other antimicrobial compounds that can be used in multiple attacks on infections by the bacterium responsible for most cases of tuberculosis has been developed by researchers at São Paulo State University (UNESP) in Brazil and is reported in an article published in the journal Carbohydrate Polymers.

20 Dec 2023

OSU study pinpoints early muscle loss mechanism in acute spinal cord injury

Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit.

20 Dec 2023

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer's disease.

20 Dec 2023

New vaccine design targets universal immunity with "chef"-inspired tool

Vaccine development aims at protecting as many people as possible from infections. Short protein fragments of pathogens, so-called epitopes, are seen as a promising new approach for vaccine development.

20 Dec 2023

A new test could save arthritis patients time, money, and pain. But will it be used?

Erinn Maury knew Remicade wasn't the right drug for Patti Schulte, a rheumatoid arthritis patient the physician saw at her Millersville, Maryland, practice. Schulte's swollen, painful joints hadn't responded to Enbrel or Humira, two drugs in the same class.

20 Dec 2023

Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

19 Dec 2023

Endometrial cancer rates rising alarmingly, particularly among Black women

The numbers are stark and deeply troubling. Endometrial cancer - which develops in the lining of the uterus (womb) and is sometimes called uterine cancer - is on the rise in the U.S. In 1987, there were 35,000 cases annually.

19 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Immune System News and Research

Small molecule-switchable RNA platform enables control of therapeutic protein expression

How immune cells shape our earliest breaths

Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency

Next-gen sequencing identifies thousands of cancer patients missing out on immunotherapy

New model links RNA editing glitch to early-stage type 1 diabetes

Spatial profiling predicts recurrence of Hodgkin lymphoma after bone marrow transplant

Previously unrecognized class of antibodies can broadly neutralize multiple virus strains

R21/Matrix-M vaccine gets WHO green light for global rollout

Unraveling nuanced roles of JAK inhibitors in inflammation

Scientists develop a method for tracking cellular events over time in living organisms

UKHSA and ONS publish latest Winter CIS data

Protein "on/off switch" controls breast cancer spread and immunotherapy response

Brazilian researchers create cutting-edge nanoparticle weapon against tuberculosis

OSU study pinpoints early muscle loss mechanism in acute spinal cord injury

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

New vaccine design targets universal immunity with "chef"-inspired tool

A new test could save arthritis patients time, money, and pain. But will it be used?

Embryonic immune sensor could key to creating patient-derived blood stem cells

Endometrial cancer rates rising alarmingly, particularly among Black women

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Understanding the DNA Damage Response in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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