Preclinical News and Research

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NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells

Cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood, combined with an investigational bispecific antibody targeting CD16a and CD30 known as AFM13, displayed potent anti-tumor activity against CD30+ lymphoma cells, according to a new preclinical study from researchers at The University of Texas MD Anderson Cancer Center.

13 May 2021

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

The importance of computational modeling in the prediction of the course of the ongoing COVID-19 pandemic, as well as evaluating multiple potential drug leads, has never been more clear. Now, a new study describes a set of designer vaccine antigens that may improve vaccine stability as well as enhance the neutralizing antibody response.

13 May 2021

UMD receives new funding to stop infection from Lyme disease pathogens before it begins

The University of Maryland received new funding from the Steven & Alexandra Cohen Foundation to develop novel therapeutic strategies that have the potential to stop infection from Lyme disease pathogens before it begins.

13 May 2021

New noninvasive imaging device could be used in biomedical research, translational medicine

A biochemical reaction between an enzyme called luciferase and oxygen causes fireflies to glow and is considered one of the most well-known examples of bioluminescence in nature.

12 May 2021

Combining biochemical and topographical cues improves quality of skeletal muscle regeneration

When trauma, illness, or injury causes significant muscle loss, reconstructive procedures for bioengineering functional skeletal muscles can fall short, resulting in permanent impairments.

12 May 2021

Researchers conduct first-in-man clinical trial for new stem cell technology

Institutes and centres under the SingHealth Duke-NUS Academic Medical Centre (AMC) are joining hands together with Singapore's first private cord blood bank, Cordlife Group Limited (Cordlife), to test a novel technology that expands the number of blood-forming stem cells from stored umbilical cord blood (UCB) in a first-in-man study in Singapore.

12 May 2021

Manganese‐enhanced MRI provides more accurate details of heart function after a heart attack

According to the British Heart Foundation, heart and circulatory diseases cause more than a quarter (27 per cent) of all deaths in the UK, which equates to more than 160,000 deaths each year - or one death every three minutes.

11 May 2021

CDK inhibitors may boost the effectiveness of immune therapy in metastatic breast cancer

A class of drugs that inhibits breast cancer progression when used with hormonal therapy might also boost the effectiveness of immune therapy in cases of recurrent, metastatic breast cancer, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

10 May 2021

Blocking fat-busting enzyme with a drug compromises cardiac repair during acute heart failure

Blocking the fat-busting enzyme lipoxygenase with a synthetic inhibitor throws the immune system's innate inflammatory response out of whack, compromising cardiac repair during acute heart failure, USF Health researchers found.

10 May 2021

Esophageal cancers turn on ancient viral DNA hidden in our genome

Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago.

10 May 2021

Novel approach to immunotherapy design could pave the way for new brain cancer treatments

A novel approach to immunotherapy design could pave the way for new treatments for people with an aggressive form of brain cancer called glioblastoma.

10 May 2021

Cardiovascular risk factors accumulated from childhood linked to poorer brain function at midlife

Managing weight, blood pressure and cholesterol in children may help protect brain function in later life, according to new research published today in the American Heart Association's flagship journal Circulation.

10 May 2021

Preclinical study finds sex differences in neurological response to SARS-CoV-2 infection

Neurological problems during and after COVID-19 are persistent and frequent. However, research is still ongoing as to why certain people exhibit specific symptoms. Research led by Yi-Ping Hsueh from the Institute of Molecular Biology in Taiwan suggests SARS-CoV-2 infection in the brain could be sex-dependent.

10 May 2021

Study identifies most persistent neurological problems during long COVID-19

Neuropsychiatric issues have been frequently reported in coronavirus disease 2019 (COVID-19) long-haulers. A new study on the medRxiv* preprint server has found which neurological symptoms are likely to persist after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

10 May 2021

Targeted therapies could exploit unique metabolic features of pancreatic cancer cells

Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them.

7 May 2021

Using ultrasound and RNA-loaded nanoparticles to deliver potent medicine to brain tumors

RNA-based drugs have the potential to change the standard of care for many diseases, making personalized medicine a reality. This rapidly expanding class of therapeutics are cost-effective, fairly easy to manufacture, and able to go where no drug has gone before, reaching previously undruggable pathways.

7 May 2021

Researchers develop a multivalent vaccine for COVID-19 and influenza

Researchers at Duke University, USA, are looking into the possibility of a combined influenza and COVID-19 vaccine that could be used to simultaneously protect against annual flu strains and the SARS-CoV-2. Preclinical results showed the vaccine protected mice from both SARS-CoV-2 and the flu.

6 May 2021

Preclinical News and Research

NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

UMD receives new funding to stop infection from Lyme disease pathogens before it begins

New noninvasive imaging device could be used in biomedical research, translational medicine

Combining biochemical and topographical cues improves quality of skeletal muscle regeneration

Researchers conduct first-in-man clinical trial for new stem cell technology

Manganese‐enhanced MRI provides more accurate details of heart function after a heart attack

CDK inhibitors may boost the effectiveness of immune therapy in metastatic breast cancer

Blocking fat-busting enzyme with a drug compromises cardiac repair during acute heart failure

Esophageal cancers turn on ancient viral DNA hidden in our genome

Novel approach to immunotherapy design could pave the way for new brain cancer treatments

Cardiovascular risk factors accumulated from childhood linked to poorer brain function at midlife

Preclinical study finds sex differences in neurological response to SARS-CoV-2 infection

Study identifies most persistent neurological problems during long COVID-19

Targeted therapies could exploit unique metabolic features of pancreatic cancer cells

Using ultrasound and RNA-loaded nanoparticles to deliver potent medicine to brain tumors

Researchers develop a multivalent vaccine for COVID-19 and influenza

Repurposing an existing, cheap drug into long-acting injectable therapy to treat Covid-19

UIC researcher finds potential new way to treat chronic migraine

New $10.7 million project aims to study the genetic underpinnings of Alzheimer's disease

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