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Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

Currently, spinal cord injury does not have any effective treatments; physical rehabilitation can help patients regain some mobility, but for severe cases the outcomes are extremely limited by the failure of spinal neurons to regenerate naturally after injury.

20 Sep 2022

Overload of stress granules enables the growth of obesity-related pancreatic cancer

Obesity is a known risk factor for at least 13 types of cancer, in part because it creates ever-present inflammatory state. For years, one researcher has wondered if there's more to the story than inflammation.

20 Sep 2022

Cell's anti-aging structures can set the damage threshold a cancer cell can sustain, study shows

A new study led by Claus M. Azzalin, group leader at Instituto de Medicina Molecular João Lobo Antunes- iMM and published today in the prestigious scientific journal Proceedings of the National Academy of Sciences (PNAS) shows, for the first time, that the cell's anti-aging structures – the telomeres – can set the damage threshold a cancer cell can sustain and above which cells cannot continue to divide and die.

20 Sep 2022

The potential of nanobody engineering in the development of SARS-CoV-2 antivirals and diagnostic tools

Researchers investigated nanobody engineering to develop antivirals and diagnostic tools against SARS-CoV-2.

20 Sep 2022

Highly sensitive mask can detect respiratory viruses in the air within 10 minutes

Scientists have created a face mask that can detect common respiratory viruses, including influenza and the coronavirus, in the air in droplets or aerosols.

19 Sep 2022

Mechanical forces generated by T cells influence the destruction of cancer cells

As a part of our immune defenses, cytotoxic T cells – or killer T cells – seek out and destroy cells that are infected or cancerous. This process is essential for the body's defense against diseases.

15 Sep 2022

Large molecules glom together into dense droplets to create squishy circuits in cells

An emerging field explores how groups of molecules condense together inside cells, the way oil droplets assemble and separate from water in a vinaigrette.

14 Sep 2022

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Through extensive single-cell analysis, researchers at The University of Texas MD Anderson Cancer Center have created a spatial map of tumor-infiltrating B cells and plasma cells in early-stage lung cancers, highlighting previously unappreciated roles these immune cells play in tumor development and treatment outcomes.

13 Sep 2022

New drug marks cancer cells for destruction by the immune system

Tumor cells are notoriously good at evading the human immune system; they put up physical walls, wear disguises and handcuff the immune system with molecular tricks.

13 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

$Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer$

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that the targeted therapy fruquintinib significantly improved overall survival (OS) and progression-free survival (PFS) in patients with refractory metastatic colorectal cancer.

13 Sep 2022

How effective is vitamin D supplementation in COVID-19?

The current paper addresses the considerable evidence now supporting the efficacy of vitamin D in COVID-19, as well as its safety.

13 Sep 2022

LJI scientists uncover major clue toward developing new antiviral therapies against flaviviruses

Zika virus has a trick up its sleeve. Once inside the body, the virus likes to make a bee line for dendritic cells, the cells we rely on to launch an effective immune response.

12 Sep 2022

Exercise hormone reduces protein levels linked to Parkinson's disease

Researchers from Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice.

12 Sep 2022

Molecule News and Research

Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

Overload of stress granules enables the growth of obesity-related pancreatic cancer

Cell's anti-aging structures can set the damage threshold a cancer cell can sustain, study shows

The potential of nanobody engineering in the development of SARS-CoV-2 antivirals and diagnostic tools

Highly sensitive mask can detect respiratory viruses in the air within 10 minutes

Mechanical forces generated by T cells influence the destruction of cancer cells

Large molecules glom together into dense droplets to create squishy circuits in cells

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

New drug marks cancer cells for destruction by the immune system

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Fruquintinib provides survival benefits for patients with refractory metastatic colorectal cancer

How effective is vitamin D supplementation in COVID-19?

LJI scientists uncover major clue toward developing new antiviral therapies against flaviviruses

Exercise hormone reduces protein levels linked to Parkinson's disease

Research could lead to a new therapeutic option for patients with bladder cancer

Small molecule inhibitor found to be effective against SARS-CoV-2 variants

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

Study reveals gut-brain circuits drive cravings for fatty foods

Label-free trace detection of bio-molecules by LI-SERS method

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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