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Exercise transiently suppresses inflammation in rheumatic disease

Research findings presented today at the European League Against Rheumatism Annual Congress suggest that exercise transiently suppresses local and systemic inflammation, reinforcing the beneficial effects of exercise and the need for this to be regular in order to achieve clinical efficacy in rheumatic disease.

12 Jun 2014

High-volume deep well plates available from Porvair Sciences

Precisely manufactured to SLAS/ANSI specifications - Porvair Sciences 24-well deep well plates permit users to simply undertake multiple, high volume (10ml / well) experiments in a single unit maximising both productivity and operational flexibility.

From Chromatrap® - Porvair Sciences Ltd 12 Jun 2014

Hunterdon Regional Cancer Center offers immuno-therapy clinical trial for lung cancer

According to the American Cancer Society, lung cancer is the second most common cancer among men and women and the leading cause of death in the United States. In 2014, it is estimated that 224,210 people will be diagnosed with lung cancer.

11 Jun 2014

Dendrimer offers a simple way of creating vesicles

One of the defining features of cells is their membranes. Each cell's repository of DNA and protein-making machinery must be kept stable and secure from invaders and toxins. Scientists have attempted to replicate these properties, but, despite decades of research, even the most basic membrane structures, known as vesicles, still face many problems when made in the lab. They are difficult to make at consistent sizes and lack the stability of their biological counterparts.

11 Jun 2014

Celgene: OTEZLA phase III study for psoriatic arthritis meets primary endpoint

Celgene International Sàrl, a wholly-owned subsidiary of Celgene Corporation (NASDAQ:CELG), today announced results of additional analyses from the phase III clinical trials of OTEZLA, the Company's oral, selective inhibitor of phosphodiesterase 4 (PDE4).

11 Jun 2014

Protein Metrics introduces top-down analysis as part of 2.0 release of Byonic proteomics search engine

Protein Metrics, Inc., a leading provider of software for rapid and thorough protein and peptide characterization, today announced the introduction of top-down analysis as part of the 2.0 release of its Byonic™ proteomics search engine.

11 Jun 2014

New mechanism explains novel aspects of how wiring of neurons in brain works

How neurons are created and integrate with each other is one of biology's greatest riddles. Researcher Dietmar Schmucker from VIB-KU Leuven unravels a part of the mystery in Science magazine.

11 Jun 2014

Gene variant that increases risk of type 2 diabetes identified in Latino individuals

A genetic analysis of DNA samples of approximately 3,700 Mexican and U.S. Latino individuals identified a gene variant that was associated with a 5-fold increase in the prevalence of type 2 diabetes, findings that may have implications for screening in this population, according to a study in the June 11 issue of JAMA, a diabetes theme issue.

11 Jun 2014

Grain legume crops overlooked as potentially valuable sources of micronutrients

Popular diets across the world typically focus on the right balance of essential components like protein, fat, and carbohydrates. These items are called macronutrients, and we consume them in relatively large quantities.

11 Jun 2014

Paradigm shift in new, highly targeted leukaemia therapy

Australian researchers are zeroing in on a promising new approach to killing off cancer cells in patients with leukemia.

11 Jun 2014

Scientists find out what goes wrong in cancer cell

Cancer - about one in three Europeans is confronted with this diagnosis during their lifetime. Scientists at the German Cancer Research Center DKFZ in Heidelberg are investigating the development of cancerous cells to find out how their growth is controlled and what goes wrong in a cancer cell.

11 Jun 2014

Researchers discover new class of tumor

This is the story of two perfectly harmless genes. By themselves, PAX3 and MAML3 don't cause any problems. However, when they combine during an abnormal but recurring chromosomal mismatch, they can be dangerous.

11 Jun 2014

Scientists discover important new biomarker that could improve HER2 targeted cancer treatments

Scientists from the School of Pharmacy & Pharmaceutical Sciences, Trinity College Dublin have made a significant discovery of a new biomarker which may help overcome resistance to newer and more targeted anti-cancer drugs, such as Herceptin, for HER2 positive cancers. These findings may also help the early identification of patients who will benefit more from these treatments.

11 Jun 2014

UCF College of Nursing interim dean receives NIH grant to improve care for critically-ill patients

More than one hospital television drama has played out an emergency room scene where a patient has to be "tubed" to re-establish breathing.

11 Jun 2014

Researchers discover strong genetic risk factor for type 2 diabetes in Latin American patients

In the largest study of its kind published to date, an international team of researchers in Mexico and the United States has discovered a strong genetic risk factor for type 2 diabetes that primarily affects Latin American patients, but is rare elsewhere.

11 Jun 2014

Celsion signs definitive asset purchase agreement to acquire EGEN

Celsion Corporation (Celsion) (NASDAQ: CLSN), an oncology drug development company, and EGEN, Inc. (EGEN), a privately-held biopharmaceutical company focused on the development of nucleic acid-based therapeutics for the treatment of cancer and other difficult to treat diseases, today announced the signing of a definitive asset purchase agreement in which Celsion will acquire substantially all of the assets of EGEN, including its Phase Ib DNA-based immunotherapy product candidate EGEN-001 and its therapeutic platform technologies, TheraPlas™ for delivery of DNA and mRNA, TheraSilence™ for delivery of RNA, and RAST™ for Cell Enabled Expression and Secretion of RNA.

10 Jun 2014

Exercise and diet impact on gut microbial diversity

Scientists at the Science Foundation Ireland-funded Alimentary Pharmabiotic Centre (APC) at University College Cork and Teagasc Food Research Centre, Moorepark, have carried out a study in conjunction with the Irish Rugby Football Union that has revealed that exercise and associated dietary changes influence gut microbial diversity.

10 Jun 2014

Inovio evaluates responses of immunotherapy product in treating HPV linked head and neck cancer

Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) today announced it has initiated a phase I/IIa clinical trial to evaluate safety, immunogenicity and clinical responses of its immunotherapy product, INO-3112, in treating human papillomavirus (HPV)- associated head and neck cancer.

10 Jun 2014

Findings add surprising new dimension to understanding of antibody repertoires

As elite soldiers of the body's immune response, B cells serve as a vast standing army ready to recognize and destroy invading antigens, including infections and cancer cells. To do so, each new B cell comes equipped with its own highly specialized weapon, a unique antibody protein that selectively binds to specific parts of the antigen.

10 Jun 2014

Wistar findings suggest means of boosting initial immune response

Your first response to an infectious agent or antigen ordinarily takes about a week, and is relatively weak. However, if your immune system encounters that antigen a second time, the so-called memory response is rapid, powerful, and very effective.

10 Jun 2014