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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

IgG antibodies reduce viral load of SARS-CoV-2

A study conducted by researchers at the University of Washington has highlighted the importance of serological testing for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

26 May 2020

Novel testing system predicts outcomes in patients with sepsis

More than 1.7 million Americans develop sepsis each year, and more than 270,000 die from it. The condition--which happens when the body has an extreme response to a bacterial or viral infection, causing a chain reaction that can lead to organ failure and death--has few strategies for treatment.

26 May 2020

Capillary leakage important in COVID-19 respiratory distress

Now, a new study published on the preprint server medRxiv reports the pivotal role played by protein leakage through lung capillaries and promotes the use of serum albumin as a biomarker of disease progression and severity.

24 May 2020

Novel biomarkers linked to improved outcomes with immunotherapy in metastatic breast cancer

Two novel biomarkers have been found to correlate with improved outcomes with immunotherapy in metastatic breast cancer and may help to identify the patients most likely to benefit from this treatment, according to exploratory studies reported at the ESMO Breast Cancer Virtual Meeting 2020.

22 May 2020

Recommendations for treating bladder cancer during COVID-19 pandemic

Bladder cancer is associated with significant illness and mortality, particularly if treatment is delayed.

22 May 2020

Durvalumab plus chemotherapy improved overall survival rate for mesothelioma patients

PrECOG, LLC is reporting clinical efficacy and biomarker analyses from its single-arm phase two study PrE0505 for the initial treatment of patients with malignant pleural mesothelioma.

20 May 2020

New test strip could provide accurate point-of-care diagnostics for cancer, COVID-19

A new synthetic paper for finger-prick blood tests could provide accurate point-of-care diagnostics for cancer, COVID-19, and other serious diseases.

20 May 2020

Novel microRNA biomarker could help detect lymph node metastases in pancreatic cancer patients

For years, surgeons have operated on pancreatic cancer patients to remove what they thought was a localized tumor only to discover that the disease had spread to other, inoperable parts of the body. Now, a City of Hope molecular scientist thinks he may have found a way to prevent ineffective surgeries and prolong the lives of these patients.

18 May 2020

Fibroblasts of different pancreatic diseases exhibit distinct properties, study reveals

Fibroblasts present in different pancreatic diseases are genetically distinct and their functions are 'programmed' by the unique environment of each disease, according to new research from the University of Liverpool (UK).

18 May 2020

SMART researchers awarded NMRC funding to develop rapid paper-based COVID-19 tests

Singapore-MIT Alliance for Research and Technology, MIT's research enterprise in Singapore, has received a grant from the National Medical Research Council COVID-19 Research fund for the acceleration of research and development of rapid paper-based serological and diagnostic tests for COVID-19.

18 May 2020

Study aims to identify markers that predict how COVID-19 affects patients

COVID-19 is the UK's largest public health crisis since World War II. There is an urgent need to identify why some patients with the virus do very well whereas others need to be admitted to intensive care and may die from the disease.

18 May 2020

New book demystifies the molecular biology of breast cancer

Breast cancer is known as one of the most deadly diseases among women. However, recent advancements in the imaging tools and diagnostic methods for breast cancer has improved the screening in the past few years.

15 May 2020

High DPP3 concentration in the blood predicts multiple organ failure in burn patients

Diagnostics company SphingoTec GmbH ("sphingotec") and 4TEEN4 Pharmaceuticals GmbH ("4TEEN4") announced today the publication of new data showing that high blood levels of Dipeptidyl Peptidase 3 (DPP3) are indicating upcoming multiple organ failure and mortality risk in burn patients.

15 May 2020

New imaging device can help detect early biomarker of Alzheimer’s disease

Biomedical engineers at Duke University have devised a new imaging device capable of measuring both the thickness and texture of the various layers of the retina at the back of the eye.

15 May 2020

New eco-evolutionary mathematical model can predict prostate cancer aggressiveness

Prostate cancer is the most common cancer in men. One in nine men will be diagnosed during their lifetime. While most men will not die from prostate cancer, there is a small subset of patients whose disease is so aggressive at the time of diagnosis that surgery and radiation are not able to control their cancer.

14 May 2020

Trial E3311: Less intense treatment for HPV+ oropharynx cancer shows positive results

The final results of the randomized phase two trial E3311 will be presented at the American Society of Clinical Oncology annual meeting, to occur virtually from May 29-31.

13 May 2020

Nanosized silver cubes can make it easier to read diagnostic tests

Engineers at Duke University have shown that nanosized silver cubes can make diagnostic tests that rely on fluorescence easier to read by making them more than 150 times brighter.

13 May 2020

Researchers identify changes in the aging brain related to blood circulation

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have identified changes in the aging brain related to blood circulation.

7 May 2020

Study finds race-specific lupus nephritis biomarkers for early diagnosis, treatment

University of Houston Hugh Roy and Lillie Cranz Cullen Endowed Professor of biomedical engineering, Chandra Mohan, and his team have discovered a difference in urinary biomarker proteins of lupus nephritis in patients according to race.

6 May 2020

AI-based technology could help accelerate clinical trials for glaucoma

The technology, supported by an artificial intelligence (AI) algorithm, could help accelerate clinical trials, and eventually may be used in detection and diagnostics, according to the Wellcome-funded study published today in Expert Review of Molecular Diagnostics.

4 May 2020

Biomarker News and Research

Further Reading

IgG antibodies reduce viral load of SARS-CoV-2

Novel testing system predicts outcomes in patients with sepsis

Capillary leakage important in COVID-19 respiratory distress

Novel biomarkers linked to improved outcomes with immunotherapy in metastatic breast cancer

Recommendations for treating bladder cancer during COVID-19 pandemic

Durvalumab plus chemotherapy improved overall survival rate for mesothelioma patients

New test strip could provide accurate point-of-care diagnostics for cancer, COVID-19

Novel microRNA biomarker could help detect lymph node metastases in pancreatic cancer patients

Fibroblasts of different pancreatic diseases exhibit distinct properties, study reveals

SMART researchers awarded NMRC funding to develop rapid paper-based COVID-19 tests

Study aims to identify markers that predict how COVID-19 affects patients

New book demystifies the molecular biology of breast cancer

High DPP3 concentration in the blood predicts multiple organ failure in burn patients

New imaging device can help detect early biomarker of Alzheimer’s disease

New eco-evolutionary mathematical model can predict prostate cancer aggressiveness

Trial E3311: Less intense treatment for HPV+ oropharynx cancer shows positive results

Nanosized silver cubes can make it easier to read diagnostic tests

Researchers identify changes in the aging brain related to blood circulation

Study finds race-specific lupus nephritis biomarkers for early diagnosis, treatment

AI-based technology could help accelerate clinical trials for glaucoma

Event guide: World Clinical Biomarkers & CDx Summit Japan eBook

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