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New trial shows benefit of digitoxin in patients with severe heart failure symptoms

Digitoxin reduced the risk of a composite of all-cause death and hospitalization for worsening heart failure (HF) among patients with advanced HF and a reduced ejection fraction (HFrEF), according to a late-breaking trial presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

$Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction$

Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction

Beta-blocker therapy significantly reduced a composite endpoint of all-cause mortality, new myocardial infarction (MI) and heart failure (HF) compared with no beta-blocker therapy in the subgroup of patients with MI and mildly reduced left ventricular ejection fraction (LVEF), according to an individual patient data meta-analysis presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Diabetes drug metformin alters blood metal levels in humans

The widely used diabetes drug metformin changes blood metal levels in humans. The Kobe University study is an important step in understanding the drug's many actions and designing better ones in the future.

1 Sep 2025

First ESC statement on mental health and heart disease promotes integrated care

A new ESC Clinical Consensus Statement is calling for greater awareness of the multidirectional relationship between mental health conditions and cardiovascular disease to improve patient health.

30 Aug 2025

Updated guidelines aim to standardize valvular heart disease care across Europe

Updated ESC/EACTS Guidelines, being published today at ESC Congress 2025, aim to improve the way that patients with valvular heart disease are diagnosed and treated, responding to robust new evidence that suggests some newer and less invasive treatments could be offered more widely and consistently to patients.

30 Aug 2025

New ESC guidelines introduce unified approach to improve myocarditis and pericarditis care

New ESC Guidelines to improve the diagnosis and care of patients with myocarditis and pericarditis, have been published today at ESC Congress 2025.

30 Aug 2025

ESC releases new guidance on lipid management to reduce cardiovascular risk

New ESC/EAS Focused Update to Guidelines, about how best to manage lipid levels in patients to reduce cardiovascular risk, recommends the use of new cardiovascular risk predication algorithms. The update was published today at ESC Congress 2025.

30 Aug 2025

New ESC guidelines prioritize women's autonomy in high-risk pregnancies

Updated ESC Guidelines, published today at ESC Congress 2025, put a focus on a woman's autonomy in making her own reproductive choices by promoting a transparent dialogue and shared decision-making for pregnancies that are high-risk for an adverse maternal and/or fetal event.

30 Aug 2025

REBOOT trial finds no benefit of beta blockers after uncomplicated heart attacks

Beta blockers-drugs commonly prescribed for a range of cardiac conditions, including heart attacks-provide no clinical benefit for patients who have had an uncomplicated myocardial infarction with preserved heart function.

30 Aug 2025

Insights into clinical features and genetic variants of Cornelia de Lange syndrome in China

Cornelia de Lange syndrome (CdLS) is a rare genetic disorder with symptoms, including facial anomalies (such as fused eyebrows, short nose, upturned nose tip, and downturned mouth corners), growth retardation, small head (microcephaly), developmental delays, cognitive impairments, excess hair growth, and limb anomalies.

29 Aug 2025

Alzheimer’s research uncovers a new therapeutic pathway for the memory-robbing malady

The gut contains the largest collection of immune cells in the body. New research at the Buck Institute shows that some of those immune cells travel along the brain/gut axis in a mouse model of Alzheimer's disease (AD) providing a potential new therapeutic pathway for the memory-robbing malady.

29 Aug 2025

Proteomic study reveals new drug targets in gastric signet ring cell carcinoma

Gastric signet ring cell carcinoma (GSRCC) is a distinct subtype of gastric cancer (GC) with unique epidemiological and pathogenic characteristics.

29 Aug 2025

Many preschoolers with ADHD receive medication before behavioral therapy

Young children with attention deficit/hyperactivity disorder often receive medication just after being diagnosed, which contravenes treatment guidelines endorsed by the American Academy of Pediatrics, a Stanford Medicine-led study has found.

29 Aug 2025

Inherited DNA changes can cause hormone imbalance in women with polycystic ovary syndrome

Increased testosterone levels are a consistent hormonal abnormality in women with polycystic ovary syndrome (PCOS). This study identified specific DNA variants in the gene DENND1A, which increase testosterone production in PCOS.

29 Aug 2025

Daily use of low-dose colchicine may slow growth of blood mutations linked to disease

Taking low-dose colchicine daily may slow the progression of a common acquired gene mutation found in the blood of older adults that can lead to certain blood cancers and increased risk of cardiovascular disease, according to a subanalysis of the LoDoCo2 trial published in JACC, the flagship journal of the American College of Cardiology, and simultaneously presented at ESC Congress 2025.

29 Aug 2025

Sharp rise in pertussis hospitalizations highlights need for timely vaccination

Pertussis, commonly known as whooping cough, is a vaccine-preventable disease which continues to circulate even in areas where vaccination coverage is high, and outbreaks may still occur. A study published in Eurosurveillance and conducted at Meyer Children's Hospital in Florence, Italy, has found a sharp increase in hospitalisations for pertussis among children and adolescents (patients aged 16 years or under) in 2024.

29 Aug 2025

How well does a cesarean risk calculator work?

Validated cesarean prediction tool effectively assesses delivery risks, supporting clinicians and patients in making informed decisions about labor induction.

29 Aug 2025

Sinus surgery proves more effective than antibiotics for chronic rhinosinusitis

Sinus surgery is more effective than antibiotics at treating chronic rhinosinusitis, according to a major clinical trial led by University College London (UCL) along with academics at the University of East Anglia and Guy's and St Thomas' NHS Foundation Trust.

28 Aug 2025

Food delivery riders could help speed defibrillator access in cardiac arrest emergencies

Inspired by an urgent need to improve timely defibrillation for out-of-hospital cardiac arrests (OHCA) in dense urban settings, a team of investigators developed a simulation that explored the potential of leveraging an existing food delivery network in Taipei City, Taiwan, to help address this challenge.

28 Aug 2025

Gut disorders forecast Alzheimer’s and Parkinson’s risk years before diagnosis

Study maps clinical, genetic, and proteomic links between gut-brain disorders and neurodegeneration, showing how diabetes, vitamin D deficiency, and bowel disorders forecast Alzheimer’s and Parkinson’s years in advance. Multimodal models in biobanks highlight early detection and personalized prevention opportunities.

28 Aug 2025

Hospital News and Research

New trial shows benefit of digitoxin in patients with severe heart failure symptoms

Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction

Diabetes drug metformin alters blood metal levels in humans

First ESC statement on mental health and heart disease promotes integrated care

Updated guidelines aim to standardize valvular heart disease care across Europe

New ESC guidelines introduce unified approach to improve myocarditis and pericarditis care

ESC releases new guidance on lipid management to reduce cardiovascular risk

New ESC guidelines prioritize women's autonomy in high-risk pregnancies

REBOOT trial finds no benefit of beta blockers after uncomplicated heart attacks

Insights into clinical features and genetic variants of Cornelia de Lange syndrome in China

Alzheimer’s research uncovers a new therapeutic pathway for the memory-robbing malady

Proteomic study reveals new drug targets in gastric signet ring cell carcinoma

Many preschoolers with ADHD receive medication before behavioral therapy

Inherited DNA changes can cause hormone imbalance in women with polycystic ovary syndrome

Daily use of low-dose colchicine may slow growth of blood mutations linked to disease

Sharp rise in pertussis hospitalizations highlights need for timely vaccination

How well does a cesarean risk calculator work?

Sinus surgery proves more effective than antibiotics for chronic rhinosinusitis

Food delivery riders could help speed defibrillator access in cardiac arrest emergencies

Gut disorders forecast Alzheimer’s and Parkinson’s risk years before diagnosis

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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