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Researchers identify mechanistic principles for engineering antibodies to enhance cadherin adhesion

Future treatments for advanced cancer could work by sticking cancer cells in place and preventing their spread around the body. A new study by researchers at the University of California, Davis, and the University of Washington shows how an antibody strengthens bonds between cells. The work is published Aug. 3 in Proceedings of the National Academy of Sciences.

5 Aug 2022

Hyaluranic acid wakes up stem cells to start muscle repair

A new study published in the journal Science reveals a unique form of cell communication that controls muscle repair.

4 Aug 2022

Study reveals the effects of an atypical mode of chromosome arrangement on genome architecture and evolution

A research team led by André Marques at the Max Planck Institute for Plant Breeding Research in Cologne, Germany, has uncovered the profound effects of an atypical mode of chromosome arrangement on genome organization and evolution.

4 Aug 2022

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Metastatic bladder cancer is generally incurable, so new therapies are an urgent need. Researchers at the University of Alabama at Birmingham now report a potential treatment for a quarter of bladder cancers.

4 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

Study shows how microglia contribute to slowdown of neuron activity linked with Alzheimer’s

One of the hallmarks of Alzheimer's disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience.

4 Aug 2022

Higher suPAR levels linked with increased risk of blood clot formation

Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms - blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.

4 Aug 2022

Therapeutic use of ketamine may be safe, study suggests

Commonly used in medicine as an anesthetic, ketamine is also increasingly prescribed to relieve depressive symptoms. This very fast-acting psychotropic drug is particularly indicated for the treatment of patients resistant to conventional antidepressants.

4 Aug 2022

Fully reduced form of vitamin K found to efficiently inhibit ferroptotic cell death

A team of researchers at Tohoku University has reported on a novel function of vitamin K, which is generally known for its importance in blood clotting.

4 Aug 2022

Queen’s researchers receive grant from Breast Cancer Now to search for new treatments

Researchers at Queen's University Belfast have received funding from Breast Cancer Now to search for new treatments inspired by COVID-19 vaccine innovation.

3 Aug 2022

Researchers unravel mechanism of action of bacterial Tc toxin in fatal attacks

A harmful and often deadly substance made by bacteria, a bacterial toxin manipulates host cell functions and disrupts vital cell processes in a living organism.

3 Aug 2022

Case series of first 3 monkeypox patients in Massachusetts treated with tecoviromat

A team of US-based scientists has described the therapeutic efficacy of a pan-Orthopoxvirus inhibitor, tecovirimat, in patients with monkeypox infection

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN Bio 3 Aug 2022

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

Liver cancer's rapid growth leads to a vulnerability in its energy-production and cell-building processes that may be potently exploited with a new combination-treatment strategy, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

3 Aug 2022

Experiments and mathematical modeling help study the role of morphogens in tissue patterning

Morphogens are molecules that travel from biological cell to cell to pattern tissues in the embryo. These molecules are important not only for the embryo during development, but also for the adult during tissue repair.

2 Aug 2022

Research could pave the way for therapeutic strategies targeting DCIR to treat colorectal tumors

Colorectal tumors are a common adverse effect of chronic inflammation of the intestine. In a new study, researchers from Japan and China demonstrate that mice models with dendritic cell immunoreceptor (DCIR) protein deficiency are resistant to colonic tumors induced by dextran sodium sulfate and azoxymethane.

2 Aug 2022

Molecule News and Research

Researchers identify mechanistic principles for engineering antibodies to enhance cadherin adhesion

Hyaluranic acid wakes up stem cells to start muscle repair

Study reveals the effects of an atypical mode of chromosome arrangement on genome architecture and evolution

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Study shows how microglia contribute to slowdown of neuron activity linked with Alzheimer’s

Higher suPAR levels linked with increased risk of blood clot formation

Therapeutic use of ketamine may be safe, study suggests

Fully reduced form of vitamin K found to efficiently inhibit ferroptotic cell death

Queen’s researchers receive grant from Breast Cancer Now to search for new treatments

Researchers unravel mechanism of action of bacterial Tc toxin in fatal attacks

Case series of first 3 monkeypox patients in Massachusetts treated with tecoviromat

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

Experiments and mathematical modeling help study the role of morphogens in tissue patterning

Research could pave the way for therapeutic strategies targeting DCIR to treat colorectal tumors

Carbon monoxide foam in the fight against inflammation

Study suggests possible benefit from melatonin in COVID-19

Is cannabidiol effective against COVID-19?

Automation of established method for isolating volatile food ingredients

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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