Mouse Model News and Research

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Scientists unveil pathology underlying optic nerve hypoplasia in children

Scientists at the Virginia Tech Carilion Research Institute (VTCRI) have revealed the pathology of cells and structures stricken by optic nerve hypoplasia, a leading cause of childhood blindness in developed nations.

16 Nov 2017

Heart injury triggers irreversible dysregulation that alters cardiosplenic and cardiorenal networks

Heart failure after a heart attack is a global epidemic leading to chronic heart failure pathology. About 6 million people in the United States and 23 million worldwide suffer from this end-stage disease.

15 Nov 2017

Study identifies molecular pathway critical to development of fibrosis

A study led by investigators at Massachusetts General Hospital and University Health Network in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis - scarring and excessive tissue deposition that result from abnormal healing responses and can compromise the function of vital organs.

15 Nov 2017

UCR-led research discovers that human protein could be used to treat sepsis

A research team led by a biomedical scientist at the University of California, Riverside has discovered that the human protein resistin could be used to treat sepsis, the body's extreme and uncontrolled immune response to an infection.

14 Nov 2017

Tulane professor wins Department of Defense grant for research into arteriovenous malformations

Tulane University's Stryder Meadows, a cell and molecular biology professor, received a $1.7 million grant from the Department of Defense to study how arteriovenous malformations (AVM), which are defects in arteries, veins and capillaries, form Hereditary Hemorrhagic Telangiectasia (HHT), a genetic disorder that affects about 1 in 5,000 people.

14 Nov 2017

Study provides new insights into basis for responsiveness of testicular cancer to chemotherapy

Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes?

14 Nov 2017

New drug shows promise in mouse model of autism disorder

Scientists have performed a successful test of a possible new drug in a mouse model of an autism disorder. The candidate drug, called NitroSynapsin, largely corrected electrical, behavioral and brain abnormalities in the mice.

14 Nov 2017

Scientists identify critical player in Alzheimer's disease pathogenesis

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check.

14 Nov 2017

Dengue immunity can provide protection from subsequent Zika infection

Manifestations of Zika virus (ZIKV) infection differ drastically. Sometimes they are catastrophic, most notably when they cause microcephaly in some babies born to infected mothers.

13 Nov 2017

Scientists develop novel mouse model to capture pathology of sporadic ALS and FTD

Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and death of nerve cells, which leads to problems with movement or mental functioning. Examples include Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

13 Nov 2017

New biomarker could lead to early detection of Alzheimer's disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a peptide that could lead to the early detection of Alzheimer's disease (AD).

10 Nov 2017

Malaria parasites’ decision making influenced by fatty molecule in human blood

Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team.

9 Nov 2017

Researchers find way to improve immunotherapy drugs’ impact while limiting side effects

By connecting highly effective cancer immunotherapy drugs such as anti-CTLA4 (ipilimumab) and anti-PD-L1 (atezolizumab) to peptides that bind to tissues in and around tumors, a research team based at the University of Chicago found a way to improve the drugs' impact while limiting treatment-related side effects.

9 Nov 2017

Researchers use gold nanoshells to effectively release cancer drugs inside tumors

Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside cancer cells in laboratory cultures.

8 Nov 2017

Chronic liver inflammation promotes cancer by suppressing immunosurveillance, study finds

Chronic inflammation is known to drive many cancers, especially liver cancer. Researchers have long thought that's because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death.

8 Nov 2017

Early intervention may be crucial to successful treatment of Friedreich's ataxia

New research published today in Disease Models & Mechanisms indicates that early intervention should be a key target in the development of new therapeutics for Friedreich's ataxia, as current treatments may be administered too late to target the disease effectively.

8 Nov 2017

Researchers develop new, three-step system to eliminate colorectal cancer

Researchers at Memorial Sloan Kettering Cancer Center in New York City and Massachusetts Institute of Technology in Boston have developed a new, three-step system that uses nuclear medicine to target and eliminate colorectal cancer.

2 Nov 2017

Preclinical studies show effectiveness of targeted therapy for glioblastoma

The targeted therapy onalespib has shown effectiveness in preclinical studies of glioblastoma by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

2 Nov 2017

Conference to focus on preventing and reversing consequences of sickle cell disease

Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society, will explore SCD- the world's most prevalent single-gene mutation disease - and new research on preventing and reversing its deadly consequences.

1 Nov 2017

New findings offer promising druggable target to root out metastatic pancreatic cancer

Cancer of the pancreas is a deadly disease, with a median survival time of less than six months. Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer's insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the cancer has almost invariably spread to other organs.

28 Oct 2017

Mouse Model News and Research

Scientists unveil pathology underlying optic nerve hypoplasia in children

Heart injury triggers irreversible dysregulation that alters cardiosplenic and cardiorenal networks

Study identifies molecular pathway critical to development of fibrosis

UCR-led research discovers that human protein could be used to treat sepsis

Tulane professor wins Department of Defense grant for research into arteriovenous malformations

Study provides new insights into basis for responsiveness of testicular cancer to chemotherapy

New drug shows promise in mouse model of autism disorder

Scientists identify critical player in Alzheimer's disease pathogenesis

Dengue immunity can provide protection from subsequent Zika infection

Scientists develop novel mouse model to capture pathology of sporadic ALS and FTD

New biomarker could lead to early detection of Alzheimer's disease

Malaria parasites’ decision making influenced by fatty molecule in human blood

Researchers find way to improve immunotherapy drugs’ impact while limiting side effects

Researchers use gold nanoshells to effectively release cancer drugs inside tumors

Chronic liver inflammation promotes cancer by suppressing immunosurveillance, study finds

Early intervention may be crucial to successful treatment of Friedreich's ataxia

Researchers develop new, three-step system to eliminate colorectal cancer

Preclinical studies show effectiveness of targeted therapy for glioblastoma

Conference to focus on preventing and reversing consequences of sickle cell disease

New findings offer promising druggable target to root out metastatic pancreatic cancer

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