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Study: Use of bone marrow mononuclear stem cells does not improve heart function

New data reported by the Cardiovascular Cell Therapy Research Network (CCTRN) at the 2013 Scientific Sessions of the American Heart Association in Dallas showed that the use of bone marrow mononuclear stem cells (BMCs) did not improve heart function significantly more at one year than at six months.

19 Nov 2013

New method could cut hours off the time it takes to diagnose blood infections

A new method could cut hours off the time it takes to diagnose blood infections while also eliminating the need for complicated manual processing and expensive equipment, according to a report to be published in mBio-, the online open-access journal of the American Society for Microbiology, on November 19.

19 Nov 2013

TOPCAT trial results of spironolactone presented at AHA Scientific Sessions

A late-breaking clinical trial, known as the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial, to be presented at the American Heart Association Scientific Sessions, November 18, 2013, demonstrates that spironolactone did not reduce the primary outcome of cardiovascular death, heart failure hospitalization, nor surviving a cardiac arrest in patients with heart failure and preserved ejection fraction (pump function). However, spironolactone did reduce the major burden faced by these patients-the risk of repeated hospitalizations for heart failure.

19 Nov 2013

Two drugs tested in larger trial fail to improve kidney function in patients with acute heart failure

Two drugs tested in a larger trial did not improve kidney function in acute heart failure patients, contrary to results of smaller studies. The results were presented today at the American Heart Association's Scientific Sessions 2013 in Dallas and simultaneously published in the Journal of the American Medical Association. Previous smaller studies showed that low-dose dopamine or low-dose nesiritide could improve kidney function and reduce fluid overload that is often present in hospitalized acute heart failure patients by increasing urine production.

19 Nov 2013

Scientists use new method to draw map of cancer's family tree

A new method to take the DNA fingerprint of individual cancer cells is uncovering the true extent of cancer's genetic diversity, new research reveals.

19 Nov 2013

Extract from bitter melon may have therapeutic qualities to treat head and neck cancer

Extract taken from an Asian vegetable may have therapeutic qualities to treat head and neck cancer, a Saint Louis University researcher has found.

19 Nov 2013

Vismodegib drug does not offer added benefits for patients with BCC

The drug vismodegib (trade name: Erivedge) is approved for the treatment of patients with two forms of basal cell carcinoma: symptomatic metastatic BCC and locally advanced BCC inappropriate for surgery or radiotherapy.

19 Nov 2013

Research findings offer new hope for millions of traumatic brain injury patients

Every year, nearly two million people in the United States suffer traumatic brain injury (TBI), the leading cause of brain damage and permanent disabilities that include motor dysfunction, psychological disorders, and memory loss. Current rehabilitation programs help patients but often achieve limited success.

19 Nov 2013

Mutations affecting immune system play important role in breast cancer

Mutations in the genes that defend the body against cancer-related viruses and other infections may play a larger role in breast cancer than previously thought, according to a study at the University of Illinois at Chicago.

19 Nov 2013

Generex Biotechnology provides update on Phase II trial of AE37 breast cancer vaccine

Generex Biotechnology Corporation today announced that it has reached a pre-specified point in the ongoing Phase II trial of its AE37 breast cancer vaccine to initiate its primary efficacy analysis. The drug is a novel immunotherapeutic cancer vaccine being developed by the Company's wholly-owned subsidiary, Antigen Express, Inc. A previously released positive interim analysis showed a strong trend toward reduced relapse in breast cancer patients receiving the AE37 vaccine.

18 Nov 2013

Gilead Sciences gets marketing authorization from European Commission for Vitekta tablets

Gilead Sciences, Inc. today announced that the European Commission has granted marketing authorization for Vitekta (elvitegravir 85 mg and 150 mg) tablets, an integrase inhibitor for the treatment of HIV-1 infection in adults without known mutations associated with resistance to elvitegravir.

18 Nov 2013

New hope for patients whose melanoma has metastasised to the brain

New data show that in patients whose melanoma (BRAF V600 mutation-positive) has spread (metastasised) to the brain, Zelboraf (vemurafenib) extends life expectancy by over six months compared to chemotherapy.1 These results are welcome news for patients suffering from metastatic melanoma, as up to half of these patients are diagnosed with brain metastases with many given less than six months to live.1

18 Nov 2013

Scientists reveal surprising role for HDAC1 proteins in development of skin tumors

Findings by scientists from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna reveal a surprising role for histone deacetylase 1 (HDAC1) - a member of a family of chromatin modifying proteins - in the development of skin tumors.

18 Nov 2013

Experts develop new working formulation for reporting of cardiac antibody-mediated rejection

Antibody-mediated rejection of the transplanted heart is a recognized clinical complication and a major limitation to survival of patients who have undergone heart transplantation. Experts have now developed a new working formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection.

18 Nov 2013

Academy of Nutrition and Dietetics supports new cardiovascular guidelines

The reality of existing insurance coverage precludes effective implementation of four newly released cardiovascular guidelines from the American Heart Association and American College of Cardiology, according to the Academy of Nutrition and Dietetics. The Academy supports the new guidelines and urges public and private insurance carriers to follow the recommendations so that Americans will have access to health care they deserve.

18 Nov 2013

Childhood cancer survivors face heart problems decades after treatment

Cancer treatment takes a toll on the hearts of child survivors, according to research presented at the American Heart Association's Scientific Sessions 2013.

18 Nov 2013

Treatment of pelvic nodes can be easily integrated into IMRT-based treatment strategy

Treatment of pelvic nodes individualized by inclusion of sentinel nodes can be easily integrated into an IMRT-based treatment strategy, according to the new study conducted by a group of researchers from T-bingen and Munich in Germany. The target volume concept seems to correctly cover individual pelvic nodes, which is indicated by the absence of any nodal recurrence within five years of follow-up.

18 Nov 2013

Aligned approach to advanced bladder cancer treatment very much needed, study says

New study, involving eight Italian research centres, concluded that an aligned approach to the treatment of advanced bladder cancer is much needed, while confirming previously published results on survival estimates of associated salvage therapies.

18 Nov 2013

Higher levels of physical fitness lower risk of heart attacks and increase survival

A new study highlights the importance of exercise and physical fitness among people with stable coronary artery disease. Researchers at the Johns Hopkins University School of Medicine and Henry Ford Hospital found that higher levels of physical fitness lower the risk of having heart attacks and increase survival in those with coronary artery disease, whether or not they have had a procedure to open up their blocked arteries.

18 Nov 2013

Study: New device helps people who lost vision due to blinding genetic disease

Research presented today at the 117th Annual Meeting of the American Academy of Ophthalmology shows promising data about a device that helps people who have lost their vision due to a blinding genetic disease to recognize common objects.

18 Nov 2013

Therapy News and Research

Study: Use of bone marrow mononuclear stem cells does not improve heart function

New method could cut hours off the time it takes to diagnose blood infections

TOPCAT trial results of spironolactone presented at AHA Scientific Sessions

Two drugs tested in larger trial fail to improve kidney function in patients with acute heart failure

Scientists use new method to draw map of cancer's family tree

Extract from bitter melon may have therapeutic qualities to treat head and neck cancer

Vismodegib drug does not offer added benefits for patients with BCC

Research findings offer new hope for millions of traumatic brain injury patients

Mutations affecting immune system play important role in breast cancer

Generex Biotechnology provides update on Phase II trial of AE37 breast cancer vaccine

Gilead Sciences gets marketing authorization from European Commission for Vitekta tablets

New hope for patients whose melanoma has metastasised to the brain

Scientists reveal surprising role for HDAC1 proteins in development of skin tumors

Experts develop new working formulation for reporting of cardiac antibody-mediated rejection

Academy of Nutrition and Dietetics supports new cardiovascular guidelines

Childhood cancer survivors face heart problems decades after treatment

Treatment of pelvic nodes can be easily integrated into IMRT-based treatment strategy

Aligned approach to advanced bladder cancer treatment very much needed, study says

Higher levels of physical fitness lower risk of heart attacks and increase survival

Study: New device helps people who lost vision due to blinding genetic disease

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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