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SLU researchers make advances in understanding plaque-causing protein in neurological disorders

In a recent paper published in the Journal of Biological Chemistry Yuna Ayala, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, and her research team made advances in understanding how a protein causes damaging plaques to build up in neurodegenerative illnesses like amyotrophic lateral sclerosis (ALS) and a form of dementia called frontotemporal lobar degeneration.

19 Apr 2017

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Working with yeast and human cells, researchers at Johns Hopkins say they have discovered an unexpected route for cells to eliminate protein clumps that may sometimes be the molecular equivalent of throwing too much or the wrong trash into the garbage disposal.

3 Mar 2017

Research provides insights on how pathogens escape process of autophagy

Our immune system has various ways to deal with threats from the outside like pathogens. One of the defence mechanisms is a process called autophagy.

3 Mar 2017

Unexpected discovery paves way for new insights in regulation of bacterial virulence

Chemists and molecular biologists have made an unexpected discovery in infection biology. The researchers can now show that two proteins that bind to one another slow down a chemical reaction central to the course of the disease in the bacteria Yersinia pseudotuberculosis.

3 Mar 2017

Changes in size of mitochondria in subset of brain cells could be key to maintaining blood sugar

Keeping blood sugar levels within a safe range is key to managing both type 1 and type 2 diabetes. In a new finding that could lead to fewer complications for diabetes patients, Yale School of Medicine researchers have found that changes in the size of mitochondria in a small subset of brain cells play a crucial role in safely maintaining blood sugar levels.

15 Feb 2017

Non-invasive imaging technique accurately detects skin cancer without surgical biopsy

Researchers funded by the National Institute of Biomedical Imaging and Bioengineering have developed a non-invasive imaging technique that accurately detects skin cancer without surgical biopsy.

13 Feb 2017

Osmium-based compound seen to target cancer cells from inside

Researchers have witnessed - for the first time - cancer cells being targeted and destroyed from the inside, by an organo-metal compound discovered by the University of Warwick.

13 Feb 2017

Research uncovers previously unknown mechanism that could be key to alternative lupus treatment

Only one new drug has become available over the past 50 years for the estimated 1.5 million Americans and five million-plus people worldwide suffering from lupus, but new research has identified a previously unknown mechanism involved in the immune response that could provide an alternative therapy target.

10 Feb 2017

VIB-KU Leuven researchers identify underlying mechanism in early onset Parkinson's disease

A team of researchers led by Patrik Verstreken have identified an underlying mechanism in early onset Parkinson's.

10 Feb 2017

Exeter scientists discover how two cell organelles interact at molecular level

Scientists have made a breakthrough in understanding how different compartments (or organelles) of human cells interact.

20 Jan 2017

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy and HIV.

18 Jan 2017

Study provides insights into CPEB4 gene and fatty liver disease

This condition generally leads to chronic inflammation (non-alcoholic steatohepatitis), which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study on the basic biology of the liver paves the way to examine therapeutic strategies to fight and prevent fatty liver disease.

18 Jan 2017

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

UT Southwestern Medical Center researchers have identified a protein that is central to the immune system's ability to recognize and destroy the bacterium responsible for the global tuberculosis (TB) epidemic.

12 Jan 2017

Study strengthens therapeutic potential for niacin-based diet in treatment of Parkinson's disease

People with certain forms of early-onset Parkinson's disease may benefit from boosting the amount of niacin in their diet, according to new research from the University of Leicester.

11 Jan 2017

How does the brain control appetite?

Energy balance between energy intake and expenditure in our bodies is important for maintaining energy homeostasis to keep our bodies functioning properly. The appetite determines how much we eat, the energy intake, by communication between the brain and body.

4 Jan 2017

New tool explains how proteins assemble into different liquid and gel-like solid states

A tool that uses light to manipulate matter inside living cells has begun to explain how proteins assemble into different liquid and gel-like solid states, a key to understanding many critical cellular operations.

30 Dec 2016

Super-resolution fluorescence microscopy sheds light on brain’s molecular mechanism

Advances in microscopy techniques have often triggered important discoveries in the field of neuroscience, enabling vital insights in understanding the brain and promising new treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's.

29 Dec 2016

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

An international team of scientists has discovered that the gene, OGDHL, a key protein required for normal function of the mitochondria -- the energy-producing factory of the cell -- and its chaperone, nardilysin (NRD1) are linked to progressive loss of neurological function in humans.

22 Dec 2016

New study reveals IRBIT's role in facilitating apoptosis

Billions of cells in our bodies die every day in an important process called apoptosis. Now, researchers at the RIKEN Brain Science Institute have mapped out a sequence of events that are necessary for apoptosis to occur properly.

21 Dec 2016

Mayo Clinic scientists show how hungry liver cells find energy

In a recent Science Advances article, Mayo Clinic researchers show how hungry human liver cells find energy.

20 Dec 2016

Organelle News and Research

SLU researchers make advances in understanding plaque-causing protein in neurological disorders

Scientists discover how misfolded proteins can damage cells’ energy-producing powerhouses

Research provides insights on how pathogens escape process of autophagy

Unexpected discovery paves way for new insights in regulation of bacterial virulence

Changes in size of mitochondria in subset of brain cells could be key to maintaining blood sugar

Non-invasive imaging technique accurately detects skin cancer without surgical biopsy

Osmium-based compound seen to target cancer cells from inside

Research uncovers previously unknown mechanism that could be key to alternative lupus treatment

VIB-KU Leuven researchers identify underlying mechanism in early onset Parkinson's disease

Exeter scientists discover how two cell organelles interact at molecular level

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Study provides insights into CPEB4 gene and fatty liver disease

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

Study strengthens therapeutic potential for niacin-based diet in treatment of Parkinson's disease

How does the brain control appetite?

New tool explains how proteins assemble into different liquid and gel-like solid states

Super-resolution fluorescence microscopy sheds light on brain’s molecular mechanism

Scientists discover OGDHL and NRD1 genes linked to progressive loss of neurological function

New study reveals IRBIT's role in facilitating apoptosis

Mayo Clinic scientists show how hungry liver cells find energy

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