Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

New proteomics studies help gain more insights into Alzheimer's, cancer and listeriosis

The brains of people with Alzheimer's disease contain many protein aggregates outside of cells, known as plaques. These are mainly made of the peptide amyloid-beta, which is released from the plasma membrane when the protease BACE1 cleaves its membrane-anchored precursor protein.

19 Jul 2018

Researchers identify new potential target protein for colon cancer

Researchers at Boston University School of Medicine have identified a new potential target protein they believe can help further the understanding of colon cancer and ultimately survival of patients with the disease.

18 Jul 2018

Researchers identify key protein involved in irregular brain cell activity

In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor suppressor.

17 Jul 2018

Researchers find elevated biomarkers of brain injury after high-acceleration head impacts

Researchers from the University of Michigan found that serum levels of two biomarkers of traumatic brain injury, tau and ubiquitin C-terminal hydrolase L1, are elevated following high-acceleration head impacts, even when there is no clinical diagnosis of concussion.

3 Jul 2018

New discovery could have significant implications in brain aging and cancers

Scientists at the University of Sheffield have discovered what keeps the perfect balance of breaks and repairs in our DNA - something which could help improve the success of chemotherapy and combat neurodegeneration associated with aging.

13 Jun 2018

Synthetic gene reveals potential therapeutic target for rare, inherited disease

DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react and patch up the affected DNA strands.

11 Jun 2018

Study could open up new treatment approaches for neurodegenerative diseases

Cell biologists have deepened understanding of proteins associated with neurodegenerative diseases. The findings could open up new treatment approaches for disorders including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS), among others.

31 May 2018

Scientists report new strategy for fighting bacteria

Antimicrobial resistance is a major medical problem worldwide, impacting both human health and economic well-being.

24 May 2018

Researchers characterize new protein that plays key role in genetic stability of cells

Researchers from the Novo Nordisk Foundation Center for Protein Research at the Faculty of Health and Medical Sciences have characterized a new protein that is important to the genetic stability of our cells.

3 May 2018

Researchers identify protein crucial for leukemia's aggressiveness

Researchers have identified a protein critical for the aggressiveness of T-cell leukemia, a subtype of leukemia that afflicts children and adults.

27 Apr 2018

Researchers find link between increased proteostasis and immortality of stem cells

Stem cells are considered to be immortal in culture and, therefore, of great interest for aging research. This immortality is regulated by increased proteostasis, which controls the quality of proteins.

8 Mar 2018

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB pathway, which is associated with accelerated cellular aging, based on the analysis of the function of the SirT6 protein.

19 Jan 2018

Scientists provide insights into crucial interaction for DNA repair

Osaka University scientists, in collaboration with The University of Tokyo, describe the crystal structure of RNF168 bound to ubiquitin chains, a crucial interaction for DNA repair, to find a unique interaction DNA is like the computer code of the body, and it must be preserved for our bodies to survive.

16 Jan 2018

Study suggests new target to treat prostate cancer

Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.

22 Dec 2017

Researchers find new role for SHARPIN protein in melanoma growth

Researchers at Sanford Burnham Prebys Medical Discovery and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex, regulating NFκB and other inflammatory molecules, SHARPIN modulates PRMT5, an epigenetic master switch that controls several proteins linked to melanoma. The research was published in The Journal of Clinical Investigation.

12 Dec 2017

Research findings offer path for drug discovery to treat hyperaldosteronism

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute, in collaboration with researchers at Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health, identifies a mechanism that explains the development of hyperaldosteronism.

7 Dec 2017

New strategy offers therapeutic alternative to prevent excessive clotting in kidney disease patients

Researchers at Boston University School of Medicine have discovered a potential treatment target to prevent chronic kidney disease patients from developing blood clots without causing bleeding complications - an unwanted and perplexing side effect.

29 Nov 2017

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

In the fight against brain damage caused by stroke, researchers have turned to an unlikely source of inspiration: hibernating ground squirrels.

17 Nov 2017

Research suggests possibility of preventing and treating Parkinson's disease using licorice extract

DGIST's research team led by Dr. Yun-Il Lee in Well-Aging Research Center has identified a new mechanism of inhibition of dopaminergic neuronal apoptosis and suggested the possibility of preventing and treating Parkinson's disease.

8 Nov 2017

Study: Diverse autism symptoms may stem from malfunction in communication among brain cells

A defective gene linked to autism influences how neurons connect and communicate with each other in the brain, according to a study from Washington University School of Medicine in St. Louis. Rodents that lack the gene form too many connections between brain neurons and have difficulty learning.

3 Nov 2017

Ubiquitin News and Research

Further Reading

New proteomics studies help gain more insights into Alzheimer's, cancer and listeriosis

Researchers identify new potential target protein for colon cancer

Researchers identify key protein involved in irregular brain cell activity

Researchers find elevated biomarkers of brain injury after high-acceleration head impacts

New discovery could have significant implications in brain aging and cancers

Synthetic gene reveals potential therapeutic target for rare, inherited disease

Study could open up new treatment approaches for neurodegenerative diseases

Scientists report new strategy for fighting bacteria

Researchers characterize new protein that plays key role in genetic stability of cells

Researchers identify protein crucial for leukemia's aggressiveness

Researchers find link between increased proteostasis and immortality of stem cells

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Scientists provide insights into crucial interaction for DNA repair

Study suggests new target to treat prostate cancer

Researchers find new role for SHARPIN protein in melanoma growth

Research findings offer path for drug discovery to treat hyperaldosteronism

New strategy offers therapeutic alternative to prevent excessive clotting in kidney disease patients

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

Research suggests possibility of preventing and treating Parkinson's disease using licorice extract

Study: Diverse autism symptoms may stem from malfunction in communication among brain cells

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry focus eBook - The Digital Laboratory (4th edition)

Editorial Focus eBook - Proteomics (2nd Edition)

Industry Focus eBook - Life Science Microscopy (3rd Edition)

BFEB: Advances in microplate-based assays and analysis

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation