in vivo News and Research

RSS

Researchers identify potential target in the fight against MERS

First identified in 2012, the MERS-coronavirus is capable of causing severe and often fatal pneumonia. There are no effective treatments for MERS.

29 Jan 2020

New strategy using organoids to study childhood brain tumors

A new study reports the creation of in vitro models of brain tumors in children using organoids derived from stem cells, which will help to screen new drugs for efficacy and thus improve the rate of drug development. The study, titled 'Modeling medulloblastoma in vivo and with human cerebellar organoids,' is published in the journal Nature Communications.

29 Jan 2020

New way to treat stroke using an already FDA-approved drug shows promise

Stroke is the third leading cause of death and disability in the United States. More than 87 percent are ischemic strokes, caused by obstruction of one or more cerebral arteries. With limited progress in developing treatments, there is a critical need for neuroprotective agents to effectively treat stroke.

29 Jan 2020

New blood sugar tool could one day replace uncomfortable finger-prick test

Researchers have developed a new way to monitor blood sugar levels that could replace the needle-prick method that people with diabetes currently use.

29 Jan 2020

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Using genetically engineered human pluripotent stem cells, University of California San Diego School of Medicine researchers created a new type of cancer model to study in vivo how glioblastoma, the most common and aggressive form of brain cancer, develops and changes over time.

29 Jan 2020

Avacta demonstrates initial proof-of-concept for TMAC drug conjugates in pre-clinical study

Avacta Group plc, the developer of Affimer biotherapeutics and reagents, is pleased to announce that it has demonstrated initial proof-of-concept for its proprietary new class of drug conjugate, TMAC, in a pre-clinical animal model of cancer.

From Avacta Life Sciences Ltd. 28 Jan 2020

Do biologists and physicists approach AFM differently?

This was the question at the forefront of my mind as I attended the Linz Winter Workshop back in February. Do biologists and physicists approach AFM differently and, does it matter?

From Nu Nano Ltd 28 Jan 2020

Improving drug testing with comprehensive 'Organ Chip' platform

The U.S. Food and Drug Administration approves only 13.8% of all tested drugs, and these numbers are even lower in "orphan" diseases that affect relatively few people.

27 Jan 2020

Biodegradable bridge for nerve injuries

Researchers have successfully tried a biodegradable bridge like device (biodegradable polycaprolactone PCL conduit) in vivo for management of nerve injuries. The team published their findings in a paper titled, “Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates,” in the latest issue of the journal Science Translational Medicine.

26 Jan 2020

Stanford scientists complete first global census of cell surface proteins

Stanford scientists have completed the first global census of diverse proteins sprouting tree-like from the outer membrane of a cell. These cell surface proteins govern how cells interact with one another and how they assemble into tissues and organs such as hearts and brains.

24 Jan 2020

Scientists visualize diabetes-related proteins at high resolution

Scientists have examined a key receptor for the first time at high resolution - broadening understanding of how it might function, and opening the door to future improvements in treating conditions such as type 2 diabetes.

24 Jan 2020

Researchers identify novel cellular entry factor for AAV vector types

Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors for in vivo gene therapy. AAVs are vectors-or vehicles--that are created from a virus that is made harmless by molecular engineering, and have shown promise transporting genetic therapy treatments to affected tissues.

23 Jan 2020

Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies

Promoting the signaling pathway of reelin -an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioral alterations seen in Alzheimer's and other pathologies associated with Tau protein, as shown in a new study with animal models -published in the journal Progress in Neurobiology.

23 Jan 2020

Scientists reverse HIV latency, take major scientific step toward curative therapies

Approximately 38 million people are infected with HIV worldwide, about 1.1 million people in the United States. Currently, people with HIV take antiretroviral therapy (ART), which can suppress HIV to undetectable levels in blood, but the virus persists throughout the body in latently infected resting CD4+ T cells.

22 Jan 2020

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a "one-size-fits-all" cancer therapy.

21 Jan 2020

Antiviral compound from banana plants shows potential for clinical use against influenza

What keeps most infectious disease researchers up at night aren't infamous viruses like Ebola. Instead, influenza, commonly known as the flu, continues to be a clear and present danger to humanity.

21 Jan 2020

Linkam automated temperature-controlled stage supports TASC method for rapid screening of drug-polymer miscibility

A new, simplified hot stage microscopy-based method, thermal analysis by structure characterization, has successfully been used to screen the miscibility of drug-polymer combinations.

20 Jan 2020

'Methylation clock' gene found to have functional role in aging of the eye

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age.

16 Jan 2020

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Emulate, Inc. announced today a published study in collaboration with Johns Hopkins University School of Medicine, that demonstrated superior functionality of the Duodenum Intestine-Chip populated with organoids, compared to organoids alone.

14 Jan 2020

Protein SV2A levels could explain poor neuronal connections in schizophrenia

A team of researchers have found that persons with schizophrenia may have lower levels of certain specific proteins that show up on their brain scans. This could help as diagnostic tools, say experts. The new study titled, “Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats”, is published in the latest issue of the journal Nature Communications.

14 Jan 2020

in vivo News and Research

Researchers identify potential target in the fight against MERS

New strategy using organoids to study childhood brain tumors

New way to treat stroke using an already FDA-approved drug shows promise

New blood sugar tool could one day replace uncomfortable finger-prick test

Researchers create new brain cancer model using genetically engineered pluripotent stem cells

Avacta demonstrates initial proof-of-concept for TMAC drug conjugates in pre-clinical study

Do biologists and physicists approach AFM differently?

Improving drug testing with comprehensive 'Organ Chip' platform

Biodegradable bridge for nerve injuries

Stanford scientists complete first global census of cell surface proteins

Scientists visualize diabetes-related proteins at high resolution

Researchers identify novel cellular entry factor for AAV vector types

Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies

Scientists reverse HIV latency, take major scientific step toward curative therapies

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Antiviral compound from banana plants shows potential for clinical use against influenza

Linkam automated temperature-controlled stage supports TASC method for rapid screening of drug-polymer miscibility

'Methylation clock' gene found to have functional role in aging of the eye

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Protein SV2A levels could explain poor neuronal connections in schizophrenia

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News