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Pharmacyclics presents ibrutinib trial data for B-cell malignancies at ASH meeting

Pharmacyclics, Inc. today announced results of 40 clinical, non-clinical and pre-clinical presentations on ibrutinib (IMBRUVICA™) at the 55TH Annual meeting of the American Society of Hematology (ASH) held in New Orleans, Dec 7 - 10, 2013.

11 Dec 2013

Merck provides update on MK-8931 investigational oral therapy for Alzheimer’s disease

Merck, known as MSD outside the United States and Canada, today provided an update on the development program for MK-8931, a novel investigational oral β-amyloid precursor protein site-cleaving enzyme (BACE) inhibitor.

11 Dec 2013

EyeTechCare's new EyeOP1 device now available in six more French health care facilities

EyeTechCare SA, which develops non-invasive therapeutic medical devices for the ophthalmology market based on the use of ultrasound, today announces that six more health care facilities in France now have the new EyeOP1 device.

11 Dec 2013

Genzyme granted Priority Review for Cerdelga investigational oral therapy for Gaucher disease

Genzyme, a Sanofi company, announced today that the Food and Drug Administration (FDA) has granted a six-month Priority Review designation to its New Drug Application (NDA) for Cerdelga™ (eliglustat), an investigational oral therapy for adult patients with Gaucher disease type 1.

11 Dec 2013

Discovery could lead to new way to combat cancer

One way to defeat an opponent is to cut off its supply lines. Tumors are no different. The supply lines for tumors are the blood vessels that ferry oxygen and nutrients to the cells. Restricting the blood vessels that feed tumor cells can shrink the tumor. A cross-institutional international team of scientists recently discovered a new, important step of the process that grows new blood vessels, a discovery that could lead to a new way to combat cancer.

11 Dec 2013

UTHealth starts clinical trial to study two forms of stem cell treatments for children with CP

A first-of-its-kind clinical trial studying two forms of stem cell treatments for children with cerebral palsy has begun at The University of Texas Health Science Center at Houston Medical School.

10 Dec 2013

Pemetrexed, paclitaxel regimens equally effective in NSCLC

PointBreak trial results suggest that pemetrexed- and paclitaxel-based chemotherapy offer comparable survival outcomes and tolerability for patients with advanced nonsquamous non-small-cell lung cancer (NSCLC) but with differing toxicity profiles.

10 Dec 2013

Biosimulation and epilepsy treatments: an interview with Dr. Serge Bischoff, CEO of Rhenovia and RHENEPI program director

The need for biosimulation is primarily to do with the very high attrition rate in drug development and especially in the development of drugs for the central nervous system.

10 Dec 2013

Researchers explain why anti-tumor activity of specific immune cells suppress during tumor growth

The Leuven-based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth.

10 Dec 2013

electroCore’s non-invasive VNS therapy for headaches reviewed at AHS and NANS meetings

electroCore’s non invasive vagus nerve stimulation therapy for the prevention and treatment of cluster headache and migraine was reviewed at both the AHS Annual Scottsdale Headache Symposium (Nov 21st to 24th) and the NANS meeting this weekend (Dec 5th to 8th).

10 Dec 2013

Restricting antibiotics use unlikely to stop spread of drug resistance in typhoid fever

Restricting the use of antibiotics is unlikely to stop the spread of drug resistance in typhoid fever, according to a study funded by the Wellcome Trust and published in the journal eLife.

10 Dec 2013

State highlights: Union, Calif. Hospital Assn. at odds over organization, ballot issues; Ind. hospital cuts worry nurses; N.C. Medicaid overhaul changes

Duane Dauner, president of the California Hospital Assn., emailed the group's board in September with a warning: The leader of the state's largest health care workers' union had told him that if hospitals did not pave the way for the organizing of 20,000 workers, the union would launch ballot measures taking aim at hospital pricing and executive pay. But negotiations on organizing agreements between the two sides stalled. In November, the union, SEIU-United Healthcare Workers West, filed two initiatives for the 2014 ballot that would limit hospital prices and cap executive compensation at nonprofit hospitals (Mason, 12/6).

10 Dec 2013

Studies expose high prevalence of epilepsy and other neurological disorders in US Veterans

Three studies coming out of the American Epilepsy Society's 67th Annual Meeting in Washington DC expose the high prevalence of epilepsy and other neurological disorders in US Veterans who served in Operation Enduring Freedom, Operation Iraqi Freedom and Operation New Dawn. The research conducted from these studies indicate that veterans are at a particularly high risk for traumatic brain injury, post traumatic stress disorder, psychological non-epileptic seizures and epileptic seizure diagnoses.

10 Dec 2013

Researchers develop new drug-eluting contact lens for prolonged delivery of glaucoma medication

For nearly half a century, contact lenses have been proposed as a means of ocular drug delivery that may someday replace eye drops, but achieving controlled drug release has been a significant challenge.

10 Dec 2013

Drugs that enhance oxidative stress kill rhabdomyosarcoma tumor cells

Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue. The findings are the latest from the St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project and appear in the December 9 edition of the scientific journal Cancer Cell.

10 Dec 2013

Children hospitalized for pneumonia have similar outcomes with big gun antibiotics or penicillin

Children hospitalized for pneumonia have similar outcomes, including length of stay and costs, regardless of whether they are treated with "big gun" antibiotics such as ceftriaxone or cefotaxime or more narrowly focused antibiotics such as ampicillin or penicillin, according to a Vanderbilt study published in Pediatrics.

10 Dec 2013

Takeda presents clinical study results of oral proteasome inhibitor MLN9708 in multiple myeloma patients

Takeda Pharmaceutical Company Limited today announced final Phase 1 and preliminary Phase 2 results of a study combining oral investigational MLN9708 administered twice a week with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma.

10 Dec 2013

Acetylon announces positive preclinical data of ricolinostat (ACY-1215) in models of lymphoma

Acetylon Pharmaceuticals, Inc., the leader in the development of selective histone deacetylase (HDAC) inhibitors for enhanced therapeutic outcomes, announced that positive preclinical data of selective HDAC6 inhibitor, ricolinostat (ACY-1215), in models of lymphoma were presented today in an oral presentation by Dr. Jennifer Amengual, Assistant Professor of Medicine & Experimental Therapeutics, Columbia University Medical Center.

10 Dec 2013

ImmunoGen presents Phase I trial results of SAR650984 at ASH annual meeting

ImmunoGen, Inc., a biotechnology company that develops targeted, antibody-based anticancer therapeutics, today announced the first clinical findings with SAR650984 reported in an oral presentation at the ASH annual meeting. The data are from an ongoing Phase I trial assessing this CD38-targeting therapeutic antibody in patients with CD38-positive MM or other hematologic malignancy.

10 Dec 2013

Study offers new insight into benefits of vitamin D in people with multiple sclerosis

In mice with a rodent form of multiple sclerosis (MS), vitamin D appears to block damage-causing immune cells from migrating to the central nervous system, offering a potential explanation for why the so-called "sunshine vitamin" may prevent or ease symptoms of the neurodegenerative disease, according to results of a study at Johns Hopkins.

9 Dec 2013

Therapy News and Research

Pharmacyclics presents ibrutinib trial data for B-cell malignancies at ASH meeting

Merck provides update on MK-8931 investigational oral therapy for Alzheimer’s disease

EyeTechCare's new EyeOP1 device now available in six more French health care facilities

Genzyme granted Priority Review for Cerdelga investigational oral therapy for Gaucher disease

Discovery could lead to new way to combat cancer

UTHealth starts clinical trial to study two forms of stem cell treatments for children with CP

Pemetrexed, paclitaxel regimens equally effective in NSCLC

Biosimulation and epilepsy treatments: an interview with Dr. Serge Bischoff, CEO of Rhenovia and RHENEPI program director

Researchers explain why anti-tumor activity of specific immune cells suppress during tumor growth

electroCore’s non-invasive VNS therapy for headaches reviewed at AHS and NANS meetings

Restricting antibiotics use unlikely to stop spread of drug resistance in typhoid fever

State highlights: Union, Calif. Hospital Assn. at odds over organization, ballot issues; Ind. hospital cuts worry nurses; N.C. Medicaid overhaul changes

Studies expose high prevalence of epilepsy and other neurological disorders in US Veterans

Researchers develop new drug-eluting contact lens for prolonged delivery of glaucoma medication

Drugs that enhance oxidative stress kill rhabdomyosarcoma tumor cells

Children hospitalized for pneumonia have similar outcomes with big gun antibiotics or penicillin

Takeda presents clinical study results of oral proteasome inhibitor MLN9708 in multiple myeloma patients

Acetylon announces positive preclinical data of ricolinostat (ACY-1215) in models of lymphoma

ImmunoGen presents Phase I trial results of SAR650984 at ASH annual meeting

Study offers new insight into benefits of vitamin D in people with multiple sclerosis

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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