Preclinical News and Research

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Study addresses multiple challenges of the pathogenesis of Huntington's disease

Recent genetic data from patients with Huntington's disease (HD) show that DNA repair is an important factor that determines how early or late the disease occurs in individuals who carry the expanded CAG repeat in the HTT gene that causes HD.

12 Feb 2021

Opioid use during pregnancy can cause long-lasting impairment in the infant's brain

As the number of pregnant women using opioid drugs continues to rise, questions have been raised about the long-term health effects on children exposed to these drugs in the womb.

12 Feb 2021

Ionic liquid formulation kills cancer cells, allows uniform distribution of chemotherapy to tumors

A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab.

11 Feb 2021

New review recommends a holistic approach to manage cerebral small vessel disease

Cerebral small vessel disease (SVD) is characterized by damage to the blood vessels and parenchyma in the brain. It presents as a multitude of symptoms, which makes the diagnosis difficult.

11 Feb 2021

Cell-selective nanotherapy can help treat atherosclerotic plaques

Percutaneous coronary intervention (PCI), commonly known as angioplasty with a stent, opens clogged arteries and saves lives. Despite its benefit in treating atherosclerosis that causes coronary artery disease, this common minimally-invasive procedure still poses severe complications for some patients.

11 Feb 2021

Scientists present new outlook on latest trends in peptide drug discovery and development

Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development.

10 Feb 2021

Researchers discover a recipe for cyclical regeneration of bioengineered hair

Researchers at the RIKEN Center for Biosystems Dynamics Research in Japan have discovered a recipe for continuous cyclical regeneration of cultured hair follicles from hair follicle stem cells.

10 Feb 2021

MD Anderson and Mirati Therapeutics collaborate to expand evaluation of potent KRAS inhibitors

The University of Texas MD Anderson Cancer Center and Mirati Therapeutics, Inc. today announced a strategic research and development collaboration to expand the evaluation of Mirati's two investigational small molecules, potent and selective KRAS inhibitors - adagrasib (MRTX849), a G12C inhibitor in clinical development, and MRTX1133, a G12D inhibitor in preclinical development, as monotherapy and in combination with other agents - which target two of the most frequent KRAS mutations in cancer.

10 Feb 2021

Optibrium Raises Investment to Advance Computer-Aided Drug Discovery

Optibrium™ today announced it has raised significant investment from Kester Capital.

From Optibrium Ltd. 10 Feb 2021

FDA issues EUA for bamlanivimab and etesevimab for COVID-19 treatment

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for bamlanivimab and etesevimab administered together for the treatment of mild to moderate COVID-19 in adults and pediatric patients (12 years of age or older weighing at least 40 kilograms [about 88 pounds]) who test positive for SARS-CoV-2 and who are at high risk for progressing to severe COVID-19.

10 Feb 2021

UIC researchers receive $10.15 million grant to develop treatment for dry eye conditions

Researchers at University of Illinois Chicago have been awarded a five-year, $10.15 million grant to develop a broad-spectrum immunomodulatory eye drop to treat patients with severe dry eye and ocular surface disease due to inflammatory and immune system disorders.

9 Feb 2021

Traumatic or stressful events in childhood may lead to changes in key brain structures

A new study from University of Alberta researchers has shown that traumatic or stressful events in childhood may lead to tiny changes in key brain structures that can now be identified decades later.

9 Feb 2021

A precursor to remdesivir shows therapeutic potential for COVID-19

A new study points to the potential to use the remdesivir precursor, GS-441524, as a treatment choice for COVID-19.

9 Feb 2021

4th preclinical study for Novavax in non-human primates, tests SARS-CoV-2 variants

Researchers in the United States have identified specific immune correlates that might be key to ensuring that vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protects against not only disease, but also viral transmission and emerging variants.

8 Feb 2021

Study shows efficacy of radionuclide therapy–immunotherapy combination in prostate cancer model

A combination of radionuclide therapy and immunotherapy has proven successful in slowing the progression of prostate cancer and increasing survival time, according to new research published in the February issue of The Journal of Nuclear Medicine.

8 Feb 2021

Bernese researchers develop a second generation lung-on-chip

The lung is a complex organ whose main function is to exchange gases. It is the largest organ in the human body and plays a key role in the oxygenation of all the organs.

8 Feb 2021

In vitro human blood-brain barrier model found to have a critical flaw

Cells used to study the human blood brain barrier in the lab aren't what they seem, throwing nearly a decade's worth of research into question, a new study from scientists at Columbia University Vagelos College of Physicians and Surgeons and Weill Cornell Medicine suggests.

8 Feb 2021

Novel biomarker may help identify which pancreatic cancer patients respond to CD40 agonists

Inflammation in the blood could serve as a new biomarker to help identify patients with advanced pancreatic cancer who won't respond to the immune-stimulating drugs known as CD40 agonists, suggests a new study from researchers in the Abramson Cancer Center of the University of Pennsylvania published in JCI Insight.

4 Feb 2021

Researchers call for trials of rapamycin to treat COVID-19

Researchers in the United States, China, and the UK have called for immediate large-scale clinical trials of an antibiotic called rapamycin as a prophylactic and treatment approach to coronavirus disease 2019 (COVID-19) in older individuals.

4 Feb 2021

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Pompe disease is a hereditary genetic disorder caused by a deficiency of acid alpha-glucosidase leading to build-up of glycogen in the lyosomes, which then causes cell damage in various tissues, in particular the heart, the muscles, the liver and the nervous system.

3 Feb 2021

Preclinical News and Research

Study addresses multiple challenges of the pathogenesis of Huntington's disease

Opioid use during pregnancy can cause long-lasting impairment in the infant's brain

Ionic liquid formulation kills cancer cells, allows uniform distribution of chemotherapy to tumors

New review recommends a holistic approach to manage cerebral small vessel disease

Cell-selective nanotherapy can help treat atherosclerotic plaques

Scientists present new outlook on latest trends in peptide drug discovery and development

Researchers discover a recipe for cyclical regeneration of bioengineered hair

MD Anderson and Mirati Therapeutics collaborate to expand evaluation of potent KRAS inhibitors

Optibrium Raises Investment to Advance Computer-Aided Drug Discovery

FDA issues EUA for bamlanivimab and etesevimab for COVID-19 treatment

UIC researchers receive $10.15 million grant to develop treatment for dry eye conditions

Traumatic or stressful events in childhood may lead to changes in key brain structures

A precursor to remdesivir shows therapeutic potential for COVID-19

4th preclinical study for Novavax in non-human primates, tests SARS-CoV-2 variants

Study shows efficacy of radionuclide therapy–immunotherapy combination in prostate cancer model

Bernese researchers develop a second generation lung-on-chip

In vitro human blood-brain barrier model found to have a critical flaw

Novel biomarker may help identify which pancreatic cancer patients respond to CD40 agonists

Researchers call for trials of rapamycin to treat COVID-19

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

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