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EC approves INVOKANA (canagliflozin) medication for adults with type 2 diabetes mellitus

Janssen-Cilag International NV announced today that the European Commission has approved INVOKANA (canagliflozin) in the European Union for the treatment of adults with type 2 diabetes mellitus, to improve glycaemic control[1]. Canagliflozin is an oral, once-daily medication, which belongs to a new class of medications called sodium glucose co-transporter 2 (SGLT2) inhibitors.

23 Nov 2013

FDA approves OLYSIO (simeprevir) for treatment of chronic hepatitis C infection

Janssen Therapeutics, Division of Janssen Products, LP, announced today the U.S. Food and Drug Administration has approved OLYSIO (simeprevir), an NS3/4A protease inhibitor, for the treatment of chronic hepatitis C infection as part of an antiviral treatment regimen in combination with pegylated interferon and ribavirin in genotype 1 infected adults with compensated liver disease, including cirrhosis.

23 Nov 2013

NEXAVAR tablets receive FDA approval for treatment of patients with thyroid cancer

Bayer HealthCare and Onyx Pharmaceuticals, Inc., an Amgen subsidiary, today announced that the U.S. Food and Drug Administration has approved a supplemental New Drug Application for the oral multi-kinase inhibitor NEXAVAR (sorafenib) tablets for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma refractory to radioactive iodine treatment.

23 Nov 2013

Novel drug combats psychosis in Parkinson’s disease

The non-dopaminergic drug pimavanserin reduces psychotic symptoms in patients with Parkinson’s disease without worsening motor function, shows a randomized trial.

22 Nov 2013

Sinai Hospital reports results from Phase 2a trial of apo A-I infusion therapy CSL112

Researchers from the Sinai Center for Thrombosis Research presented findings from a Phase 2a trial substudy that examined the antiplatelet effects of CSL112, a novel apolipoprotein A-I (apo A-I) infusion therapy, at the American Heart Association 2013 Scientific Sessions.

22 Nov 2013

Genetic diagnostic test for inherited eye diseases now available from Mass. Eye and Ear

The Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology today announced the availability of a comprehensive genetic diagnostic test for inherited eye diseases.

22 Nov 2013

New documentary reveals how antiretroviral therapy transformed lives of HIV people in Africa

A new documentary produced by the University of East Anglia reveals how the lives of people with HIV in Africa have been transformed by antiretroviral therapy and highlights the crucial need for continued funding of the lifesaving treatment.

22 Nov 2013

Mouse study highlights importance of microorganisms in optimal cancer treatment outcomes

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22 Nov 2013

Reason for decline in stroke deaths still remains unclear

A national group of leading scientists, including one University of Alabama at Birmingham expert, says that for more than 100 years fewer people have been dying of stroke, yet it is still unclear why this decline remains constant.

22 Nov 2013

Combinatory therapy may be effective in suppressing drug resistance in treatment of melanoma

Stand Up To Cancer (SU2C), the charitable initiative supporting ground-breaking research aimed at getting new cancer treatments to patients in an accelerated timeframe, announces that the Allan H. (Bud) and Sue Selig Stand Up To Cancer Melanoma Innovative Research Grant Recipient Roger S. Lo, M.D., Ph.D., associate professor in the Department of Medicine at the Jonsson Comprehensive Cancer Center of the University of California, Los Angeles (UCLA) has published two studies in Cancer Discovery, a journal of the American Association for Cancer Research which indicate that treatment using combinatory therapy may be effective in suppressing drug resistance in the treatment of melanoma.

21 Nov 2013

Antibiotic resistance holds stable in U.S. children's hospitals

Two studies published in the December issue of Infection Control and Hospital Epidemiology show antibiotic resistance patterns for children have held stable over a seven-year period and surgical patients in U.S. children's hospitals account for 43 percent of all antibiotic use in children's hospitals, presenting an opportunity for targeted intervention.

21 Nov 2013

State highlights: Mo. doctors propose Medicaid payment reform project; N.C. Medicaid billing problems persist; Calif. nursing home pays $48M to settle fraud case

Some doctors want to make Missouri's Medicaid program a little more like a health club. A proposal outlined by a pair of doctors Tuesday would create a pilot project in which primary care physicians would be paid a flat monthly amount for each Medicaid patient they accept (Lieb, 11/19).

21 Nov 2013

Vagus nerve stimulation-tone therapy safe for treating tinnitus, say UT Dallas researchers

UT Dallas researchers have demonstrated that treating tinnitus, or ringing in the ears, using vagus nerve stimulation-tone therapy is safe and brought significant improvement to some of the participants in a small clinical trial.

21 Nov 2013

Long-term cocaine abuse may be linked with deficits in parts of brain overseeing own behavior

New research from the Icahn School of Medicine at Mount Sinai reveals long-term cocaine abuse may be associated with deficits in parts of the brain involved in monitoring and overseeing one's own behavior.

21 Nov 2013

UK's first gene therapy trial for patients with chronic heart failure begins at GJNH

The UK’s first gene therapy trial for advanced heart failure, CUPID 2, has officially begun at the Golden Jubilee National Hospital; with the first candidate recently being administered with a dose of the MYDICAR treatment.

21 Nov 2013

Using radiation models to improve cancer therapies: an interview with Adrian Treverton, COO of Xstrahl and Jean-Pierre Wery, President of Crown Bioscience

What we are trying to do is take a cancer model like the PDX model (patient-derived tumor xenograft), which is a human-derived cancer growing in an in vivo model and apply radiation to that model.

From Xstrahl 20 Nov 2013

First Edition: November 20, 2013

Today's early morning highlights from the major news organizations, including reports that President Barack Obama places some of the blame for the health law's woes with Republicans, and details of comments by an Obama administration tech official that a large portion of the healthcare.gov 'back office' functions are yet to be built.

20 Nov 2013

DNA vaccine demonstrates potential to prevent and treat deadly MERS coronavirus

Inovio Pharmaceuticals, Inc. announced today that preclinical testing of a DNA synthetic vaccine for the virulent Middle East Respiratory Syndrome coronavirus (MERS) induced robust and durable immune responses, demonstrating the potential for a SynCon DNA vaccine to prevent and treat this deadly virus.

20 Nov 2013

Study compares prevalence, impact of chronic pain amongst different ethnic groups in Tower Hamlets

A new study in the London Borough of Tower Hamlets, funded by medical research charity Arthritis Research UK, may help improve GPs’ understanding of chronic musculoskeletal pain amongst different ethnic groups and develop better strategies for self-management as a result

20 Nov 2013

BioCardia reports positive results for Transendocardial Autologous Cells in Ischemic Heart Failure Trial

BioCardia, Inc., a leader in cardiovascular regenerative medicine, today announced positive 12-month results for the randomized Transendocardial Autologous Cells (MSC or BMC) in Ischemic Heart Failure Trial (TAC-HFT).

20 Nov 2013

Therapy News and Research

EC approves INVOKANA (canagliflozin) medication for adults with type 2 diabetes mellitus

FDA approves OLYSIO (simeprevir) for treatment of chronic hepatitis C infection

NEXAVAR tablets receive FDA approval for treatment of patients with thyroid cancer

Novel drug combats psychosis in Parkinson’s disease

Sinai Hospital reports results from Phase 2a trial of apo A-I infusion therapy CSL112

Genetic diagnostic test for inherited eye diseases now available from Mass. Eye and Ear

New documentary reveals how antiretroviral therapy transformed lives of HIV people in Africa

Mouse study highlights importance of microorganisms in optimal cancer treatment outcomes

Reason for decline in stroke deaths still remains unclear

Combinatory therapy may be effective in suppressing drug resistance in treatment of melanoma

Antibiotic resistance holds stable in U.S. children's hospitals

State highlights: Mo. doctors propose Medicaid payment reform project; N.C. Medicaid billing problems persist; Calif. nursing home pays $48M to settle fraud case

Vagus nerve stimulation-tone therapy safe for treating tinnitus, say UT Dallas researchers

Long-term cocaine abuse may be linked with deficits in parts of brain overseeing own behavior

UK's first gene therapy trial for patients with chronic heart failure begins at GJNH

Using radiation models to improve cancer therapies: an interview with Adrian Treverton, COO of Xstrahl and Jean-Pierre Wery, President of Crown Bioscience

First Edition: November 20, 2013

DNA vaccine demonstrates potential to prevent and treat deadly MERS coronavirus

Study compares prevalence, impact of chronic pain amongst different ethnic groups in Tower Hamlets

BioCardia reports positive results for Transendocardial Autologous Cells in Ischemic Heart Failure Trial

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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