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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Polygenic risk score not useful in predicting heart disease risk, study finds

A Polygenic Risk Score -- a genetic assessment that doctors have hoped could predict coronary heart disease (CHD) in patients -- has been found not to be a useful predictive biomarker for disease risk, according to a Vanderbilt study published in the Journal of the American Medical Association.

23 Feb 2020

New eye scan could aid in early detection of autism

A new eye scan could help identify autism in children years earlier than currently possible.

21 Feb 2020

Harmful levels of metal linked to DNA damage found in the urine of e-cigarette users

Researchers at the University of California, Riverside, have completed a cross-sectional human study that compares biomarkers and metal concentrations in the urine of e-cigarette users, nonsmokers, and cigarette smokers.

20 Feb 2020

Global study shows long-term survival benefit for a subset of patients with advanced lung cancer

According to the results of a large, global study led by Yale Cancer Center researchers, even a tiny amount of a biomarker known as PD-L1 (programmed death-ligand1) can predict a long-term survival benefit from using pembrolizumab (Keytruda).

20 Feb 2020

New biomarkers for diagnosis and prognosis of lung cancer identified

Applying bioinformatics to resolve biological problems. This is the objective of the research group of the University of Malaga "BI4NEXT", which, in one of its latest studies, developed in the Supercomputing and Bioinnovation Center based on biobank samples, has identified new biomarkers for the diagnosis, prognosis and even treatment of lung cancer.

20 Feb 2020

Language may be a promising biomarker for progression of Hungtinton's disease

Huntington's disease is a hereditary neurodegenerative disorder caused by a gene of chromosome 4 that affects a very important area of the brain, the striatum. People are born with the defective gene but symptoms do not appear until the age of 30 or 40.

20 Feb 2020

Plant-based diets improve heart health via the gut microbiome

A new study published in February 2020 in the Journal of the American College of Cardiology reports that a reduced intake of animal-based foods and a diet based on plants can result in a lower risk of coronary heart disease (CHD) by influencing the gut microbiome pattern to favor beneficial species.

17 Feb 2020

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

Small cell lung cancer accounts for 14% of all lung cancers and is often rapidly resistant to chemotherapy, resulting in poor clinical outcomes.

17 Feb 2020

Simple blood test measures the body's immune response to improve ovarian cancer diagnosis

Researchers have developed a simple blood test that measures the body's own immune response to improve diagnosis of ovarian cancer.

17 Feb 2020

New technique can label diverse molecules in a single tissue sample

A new technique can label diverse molecules and amplify the signal to help researchers spot those that are especially rare. Called SABER (signal amplification by exchange reaction), Peng Yin's lab at Harvard's Wyss Institute first introduced this method last year and since have found ways to apply it to proteins, DNA and RNA.

16 Feb 2020

Treating soft tissue sarcoma with shorter radiation treatment found to be safe, effective

A new study led by researchers at the UCLA Jonsson Comprehensive Cancer Center found that treating soft tissue sarcoma with radiation over a significantly shorter period of time is safe, and likely just as effective, as a much longer conventional course of treatment.

13 Feb 2020

Neuronal necrosis occurs much earlier in Alzheimer’s disease progression than previously thought

Alzheimer's remains the leading cause of dementia in Western societies, with some estimates suggesting that as many as 24 million people worldwide are living with the disease.

13 Feb 2020

Circulating ceramide ratios may be useful predictors of future dementia risk

Novel blood-based biomarkers for dementia could identify disease at an early preclinical stage, serve as surrogate outcomes for clinical trials of investigational therapies and even identify future potential therapeutic targets.

13 Feb 2020

New multiplexed electrical biosensor for accurate detection of Alzheimer's disease

A research team at KAIST reported clinically accurate multiplexed electrical biosensor for detecting Alzheimer's disease by measuring its core biomarkers using densely aligned carbon nanotubes.

11 Feb 2020

New summary report highlights advances and challenges in small cell lung cancer research

In 2017, a group of lung cancer experts posed the question: "Can recent advances in tumor biology that have led to progress treating non-small cell lung cancer translate into improved outcomes for small cell lung cancer?"

10 Feb 2020

CRISPR-edited immune cells can be safely given to cancer patients

The emergence of CRISPR-Cas9 gene-editing technology has spurred hope in both doctors and patients since it shows promise in treating a multitude of diseases, including cancer. For the first time in the United States, a team of scientists has shown that CRISPR-edited immune cells can be safely used to cancer patients.

9 Feb 2020

Study finds link between bladder cancer and collagen receptor

A team of investigators has recently discovered that the collagen receptor DDR1 functionally interacts with the insulin-like growth factor system in regulating bladder cancer.

9 Feb 2020

Researchers receive federal grant to evaluate potential imaging biomarker for Alzheimer's

Researchers at Wake Forest School of Medicine have received a five-year grant worth approximately $2.53 million from the National Institute on Aging to evaluate whether a novel brain-imaging technique can identify Alzheimer's disease in its early stages.

9 Feb 2020

Scientists identify new biomarker for identifying individuals at risk of depression

Chronic pain, or inflammation, is believed to be one of the major factors in the onset of major depressive disorder.

8 Feb 2020

New treatment approach for eosinophilic chronic rhinosinusitis

Eosinophilic chronic rhinosinusitis is a type of airway disease involving nasal inflammation. Many studies have attempted to understand the molecular-based pathogenesis of recurrent ECRS; none have provided a clear explanation, until now.

6 Feb 2020

Biomarker News and Research

Further Reading

Polygenic risk score not useful in predicting heart disease risk, study finds

New eye scan could aid in early detection of autism

Harmful levels of metal linked to DNA damage found in the urine of e-cigarette users

Global study shows long-term survival benefit for a subset of patients with advanced lung cancer

New biomarkers for diagnosis and prognosis of lung cancer identified

Language may be a promising biomarker for progression of Hungtinton's disease

Plant-based diets improve heart health via the gut microbiome

Intratumoral heterogeneity linked to chemotherapy resistance in small-cell lung cancer

Simple blood test measures the body's immune response to improve ovarian cancer diagnosis

New technique can label diverse molecules in a single tissue sample

Treating soft tissue sarcoma with shorter radiation treatment found to be safe, effective

Neuronal necrosis occurs much earlier in Alzheimer’s disease progression than previously thought

Circulating ceramide ratios may be useful predictors of future dementia risk

New multiplexed electrical biosensor for accurate detection of Alzheimer's disease

New summary report highlights advances and challenges in small cell lung cancer research

CRISPR-edited immune cells can be safely given to cancer patients

Study finds link between bladder cancer and collagen receptor

Researchers receive federal grant to evaluate potential imaging biomarker for Alzheimer's

Scientists identify new biomarker for identifying individuals at risk of depression

New treatment approach for eosinophilic chronic rhinosinusitis

Event guide: World Clinical Biomarkers & CDx Summit Japan eBook

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