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10 years of CRISPR genome editing: Advances, limitations, and future potential

In the decade since the publication of CRISPR-Cas9 as a genome editing technology, the CRISPR toolbox and its applications have profoundly changed biological research, enabling advances through applications in plants, animals, and humans.

20 Jan 2023

Heritable pathogenic defects in genes may increase the risk for sarcomas

Heritable pathogenic defects in genes related to mitosis and telomere function may specifically increase the risk for sarcomas – rare cancers that develop in muscles, bones, and other connective tissues, researchers report.

19 Jan 2023

Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study

Researchers described the evolution of the mpox virus (MPXV) before the 2022 outbreak.

19 Jan 2023

Study reveals how most-resistant pancreatic cancer cells defy treatment

Pancreatic cancer is the third deadliest cancer in the United States, after lung and colorectal, though far less common.

19 Jan 2023

Scientists decipher comprehensive deer tick genome

A University of Maryland-led team of scientists has deciphered the first comprehensive, continuous genome for a parasite responsible for transmitting Lyme disease and other serious infections to hundreds of thousands of Americans yearly.

19 Jan 2023

Comprehensive analysis of genome sequences unravels the elusive origins of bubonic plague

Seeking to better understand more about the origins and movement of bubonic plague, in ancient and contemporary times, researchers at McMaster University, University of Sydney and the University of Melbourne, have completed a painstaking granular examination of hundreds of modern and ancient genome sequences, creating the largest analysis of its kind.

19 Jan 2023

Several genes and individual genetic variations associated with atrial fibrillation discovered

In the largest genetic study of heart arrhythmia to date, researchers led by Kazuo Miyazawa and Kaoru Ito at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan report the discovery of several genes and individual genetic variations that are associated with atrial fibrillation.

19 Jan 2023

Mapping Matters: new cellular atlas of endometriosis for better understanding of the disease

In this interview, News Medical spoke to Kate Lawrenson, Ph.D., about their latest research which detailed the molecular profile of endometriosis to help improve therapeutic options for the millions of women suffering from the disease.

19 Jan 2023

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

A new study describes that tight transmission bottlenecks restrict the evolution of SARS-CoV-2 in the transmission chain. SARS-CoV-2 is the causative pathogen of the COVID-19 pandemic.

18 Jan 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

Exploring a novel amplicon-based mpox virus sequencing strategy

Researchers described the development of a sequencing strategy based on amplicons for mpox detection.

18 Jan 2023

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

Mice exposed to World Trade Center dust exhibit a significant impairment in spatial recognition and short- and long-term memory, as well as changes in genes related to immune-inflammatory responses and blood-brain barrier disruption, according to a study conducted by researchers from the Icahn School of Medicine at Mount Sinai and published January 17 in the Journal of Alzheimer's Disease.

17 Jan 2023

On four flights out of China in December, 22% of passengers were SARS-CoV-2 positive

Researchers document COVID-19 screening results in Italy of 556 flight passengers from two Chinese provinces in late December 2022.

17 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

New research finds community interactions drive antibiotic tolerance in bacteria

In a new study, researchers examined the evolutionary trajectory of a lab-grown community of bacterium, Escherichia coli, having two interacting strains.

17 Jan 2023

Study finds non-Omicron breakthrough infections elicit robust cross-neutralizing activity against Omicron variants across the antigenic barrier

Researchers assessed the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with a non-Omicron variant on SARS-CoV-2 BA.4/5 neutralization.

17 Jan 2023

Acquired mutations in 'Guardian of the Genome' accelerate the development of atherosclerosis

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in collaboration with institutes in the USA, has demonstrated that acquired mutations in the gene encoding the protein p53 contribute to the development of atherosclerotic cardiovascular disease.

16 Jan 2023

Genome News and Research

10 years of CRISPR genome editing: Advances, limitations, and future potential

Heritable pathogenic defects in genes may increase the risk for sarcomas

Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study

Study reveals how most-resistant pancreatic cancer cells defy treatment

Scientists decipher comprehensive deer tick genome

Comprehensive analysis of genome sequences unravels the elusive origins of bubonic plague

Several genes and individual genetic variations associated with atrial fibrillation discovered

Mapping Matters: new cellular atlas of endometriosis for better understanding of the disease

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

Combination of multiple maps uncovers new genetic risk factor for AMD

Exploring a novel amplicon-based mpox virus sequencing strategy

Exposure to World Trade Center particulate matter accelerates cognitive deterioration in mice model of Alzheimer's

On four flights out of China in December, 22% of passengers were SARS-CoV-2 positive

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

New research finds community interactions drive antibiotic tolerance in bacteria

Study finds non-Omicron breakthrough infections elicit robust cross-neutralizing activity against Omicron variants across the antigenic barrier

Acquired mutations in 'Guardian of the Genome' accelerate the development of atherosclerosis

First-ever method for analyzing RNA sequencing data genome-wide using a 'pantranscriptome'

New test 'fishes' for multiple respiratory viruses using DNA as 'bait'

Researchers report on the largest cohort of patients tested using plasma mcfDNA sequencing for pathogen detection

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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