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FDA Breakthrough Device designation granted for AI-based mammogram analysis tool

A new technology that harnesses AI to analyze mammograms and improve the accuracy of predicting a woman's personalized five-year risk of developing breast cancer has received Breakthrough Device designation from the Food and Drug Administration (FDA).

30 Jul 2025

PD-1 helps guide immune memory cells to the skin early during infection

Weill Cornell Medicine researchers have discovered that PD-1—a molecule best known for putting the brakes on immune cells—also plays a critical role in helping T cells become long-term immune defenders in the skin.

30 Jul 2025

Researchers classify how specific genetic mutations correspond to rare disorders

The NF-κB signaling pathway plays a pivotal role in how our bodies fight infection, heal, and regulate inflammation. At the heart of this pathway is the NEMO protein, encoded by the IKBKG gene.

30 Jul 2025

Synergistic effects of radiation and immunotherapy boost anti-tumor immunity

Head and neck squamous cell carcinomas (HNSCC) are a group of cancers that affect cells in and around our mouth and nose.

29 Jul 2025

Gut microbial metabolites restore hormone-producing cells in obesity

New research from scientists at the Marshall University Joan C. Edwards School of Medicine reveals that certain gut microbial byproducts may hold promise as a novel therapy for obesity-associated metabolic complications by restoring critical hormone-producing cells in the intestine.

29 Jul 2025

New RNA therapy reverses symptoms of progeria in mouse models

Children who develop deep wrinkles, stunted growth, and rapidly aging bones and blood vessels as early as 1 to 2 years of age may be suffering from Hutchinson-Gilford Progeria Syndrome (HGPS), a rare and incurable genetic disorder that affects approximately one in eight million people.

29 Jul 2025

Pyruvate identified as a promising oral treatment for ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory disease marked by intestinal pain, bleeding, and impaired gut barrier function.

29 Jul 2025

Senescent macrophages emerge as key drivers of tumor progression

Macrophages are versatile immune cells, tasked with cleaning up pathogens and maintaining tissue health.

29 Jul 2025

WHO urges urgent action to eliminate hepatitis and reduce liver cancer deaths

As we mark World Hepatitis Day, WHO calls on governments and partners to urgently accelerate efforts to eliminate viral hepatitis as a public health threat and reduce liver cancer deaths.

29 Jul 2025

Plant-based agent inhibits key protein to reduce bronchial thickening

A plant-based agent inhibits a protein that, among other things, is responsible for the dreaded thickening of the bronchial wall.

29 Jul 2025

Immunotherapy shows promise in changing leukemia’s cellular environment

Scientists studying a hard-to-treat form of blood cancer called acute myeloid leukemia (AML) have found that a type of treatment - immunotherapy - may help change the environment where cancer cells live, possibly helping the immune system respond more effectively.

29 Jul 2025

Exonate plans 'CLEAR-DE' Phase IIb clinical trial of lead candidate EXN407 for diabetic eye disease

Exonate Ltd., a biotechnology company developing novel, non-invasive, small-molecule therapeutics for patients with retinal vascular diseases, today announced plans to initiate a Phase IIb clinical trial for its lead candidate EXN407.

29 Jul 2025

Gut mycobiota could help predict disability in multiple sclerosis

Gut fungal communities may impact multiple sclerosis severity, offering new insights into MS pathogenesis and potential microbiome-based treatment strategies.

29 Jul 2025

Understanding immune drift in biologic therapy for inflammatory skin diseases

Immune-inflammatory skin diseases (e.g., psoriasis, atopic dermatitis) involve dysregulation of CD4+ T-cell subsets (Th1/Th2/Th17/Treg) and cytokine networks (IL-17/IL-23/IL-4).

28 Jul 2025

Restoring mitochondria enhances immune response against lung cancer

While chemotherapy remains a cornerstone of lung cancer treatment, it often weakens the immune system it relies on for long-term control.

28 Jul 2025

Metabolic rewiring turns immune cells into potent cancer fighters

Researchers have discovered a way to make the immune system's T cells significantly more effective at fighting cancer.

28 Jul 2025

Vitamin D supplementation reduces liver inflammation and fibrosis largely through TXNIP

Chronic liver disease (CLD) is a major global health concern, affecting approximately 1.5 billion people. This life-threatening disease often progresses silently, eventually leading to worsened conditions like liver cirrhosis or liver cancer.

28 Jul 2025

Advancing precision medicine in colorectal cancer with multi-omics approaches

Colorectal cancer is among the most prevalent and lethal malignancies worldwide, with liver metastases occurring in nearly one-third of patients and accounting for a major share of cancer-related deaths.

28 Jul 2025

Neutrophils emerge as key players in cancer progression and therapy

Neutrophils are the most abundant type of white blood cells, critical for immune defense and inflammation control.

28 Jul 2025

Common plant virus shows powerful potential as cancer immunotherapy

A virus that typically infects black-eyed peas is showing great promise as a low-cost, potent cancer immunotherapy-and researchers are uncovering why.

28 Jul 2025