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Genetic factors that make the bacteria behind cholera so dangerous uncovered

Study reveals key genetic factors in Vibrio cholerae O1 that drive cholera transmission and severity, highlighting targets for novel therapeutic strategies.

26 Sep 2024

Targeted drug therapy shows promise for ulcerative colitis remission

An international placebo-controlled study led by Cedars-Sinai suggests that a targeted drug therapy that was developed by researchers at Cedars-Sinai is safe and effective at helping people with moderate to severe ulcerative colitis reach clinical remission.

26 Sep 2024

Targeting tumor immunity with transferrin receptor-directed photodynamic therapy

This new article publication from Acta Pharmaceutica Sinica B, discusses a transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption.

26 Sep 2024

Could microalgae be the secret weapon to ending global hunger and saving the planet?

Researchers highlight the potential of commercially farmed microalgae to combat global undernutrition by providing essential nutrients and reducing environmental impacts.

26 Sep 2024

COVID-19 causes lasting cognitive impairment tied to brain injury markers

Researchers found that COVID-19 patients experienced widespread cognitive deficits one year post-hospitalization, associated with elevated brain injury markers and reduced brain volume. Cognitive recovery plateaued over time, suggesting lasting impacts.

26 Sep 2024

Multi-omics analysis reveals mechanism of action for ruthenium-based anti-cancer agent

This study is led by Prof. Cai-Ping Tan, Prof. Zong-Wan Mao (MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University) and Prof. Zheng-Qiu Li (School of Pharmacy, MOE Key Laboratory of Tumor Molecular Biology, Jinan University).

26 Sep 2024

Understanding SARS-CoV-2's viral strategies for infection

This new article publication from Acta Pharmaceutica Sinica B, discusses how SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites.

26 Sep 2024

Concerns raised over safety and effectiveness of donanemab for Alzheimer’s treatment

The safety and effectiveness of donanemab - an Alzheimer's drug recently approved by the US Food & Drug Administration (FDA) - is called into question in an investigation published by The BMJ today.

25 Sep 2024

Breakthrough research offers hope for improved treatment of chronic wounds

Novel research, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, has identified key molecular targets that could significantly enhance the healing of both acute and chronic wounds.

25 Sep 2024

Research questions effectiveness of MS medications in slowing disability progression

In people with primary progressive multiple sclerosis (MS), a new study has found no difference in the amount of time before disability worsened between people taking certain medications and those not receiving treatment.

25 Sep 2024

Researchers identify drug with anti-aging effects

Aging is an inevitable phenomenon and is accompanied by several comorbidities. To this end, research into the effects of aging has become paramount, and scientists are looking for ways to slow down aging and its detrimental impact on the human body.

25 Sep 2024

CRISPR-Cas13 emerges as a game changer in RNA-targeted therapies

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems.

25 Sep 2024

New deep learning algorithm predicts effects of rare genetic variants

Whether we are predisposed to particular diseases depends to a large extent on the countless variants in our genome.

25 Sep 2024

Extracellular vesicles play key role in brain development

Extracellular vesicles (EVs) are tiny bubbles released by cells, acting as cargo vessels through which cells exchange signals and thus communicate.

25 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

Combining treatments to boost tumor response in lung cancer

Researchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumors.

25 Sep 2024

A faster, cheaper method to detect immune autoantibodies in whole blood

Researchers developed a quick and affordable whole-blood assay to detect autoantibodies against type I IFNs, enabling rapid diagnostics for immune disorders. This new method has potential clinical impact by addressing key limitations of current tests.

25 Sep 2024

Research reveals key role of mucin modification in muco-obstructive diseases

With each breath, a human may inhale thousands of harmful microbes into the lungs. Mucus, the gel-like moist substance coating the airways, is one of the first lines of defense and aids in removal these microbes.

24 Sep 2024

New FDA award fuels research into autosomal dominant tubulointerstitial kidney disease

Critical Path Institute (C-Path) is thrilled to announce its Polycystic Kidney Disease Outcomes Consortium (PKDOC) has been awarded an Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) focused Broad Agency Announcement (BAA) contract from the U.S. Food and Drug Administration (FDA).

24 Sep 2024

Semaglutide shows promise in treating chronic skin condition in obese patients

A pioneering study, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, demonstrates the significant potential of semaglutide in treating hidradenitis suppurative (HS), a common and chronic skin condition, in people with obesity.

24 Sep 2024