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Intellegens and Optibrium announce success in the Open Source Malaria global initiative

Intellegens, an artificial intelligence start-up, and, Optibrium, leading providers of software and services for drug discovery, today announced joint success in the Open Source Malaria global initiative aimed at identifying the best predictive models for antimalarial compounds.

6 Dec 2019

New model can help study the mechanisms of bone metastasis, tumor immune response

The Research Team reports the establishment of B6Ca P, an allograft tumor line from a Hi-Myc transgenic mouse that had been backcrossed onto C57BL/6J background.

4 Dec 2019

Early adherence step in intestinal transit of Shigella discovered

The bacterial pathogen Shigella, often spread through contaminated food or water, is a leading cause of mortality in both children and older adults in the developing world.

4 Dec 2019

New discovery may bring scientists a step closer to developing hearing loss treatments

A new discovery from a team led by Massachusetts Eye and Ear researchers may bring scientists a step closer to developing treatments that regrow the lost cells that cause hearing loss.

4 Dec 2019

Novel approach to reach the most difficult-to-access physiological locations

A team led by Professor Sylvain Martel at the Polytechnique Montréal Nanorobotics Laboratory has developed a novel approach to tackling one of the biggest challenges of endovascular surgery: how to reach the most difficult-to-access physiological locations.

3 Dec 2019

New human colon-on-a-chip enables in vitro study of mucus physiology

We have a mutualistic but complicated relationship with the collection of microbes in our gut known as the intestinal microbiome.

3 Dec 2019

New treatment approach could improve outcomes for people with cystic fibrosis

A new approach to treating people with cystic fibrosis (CF) has been shown to reduce inflammation, which has the potential to reduce the need for lung transplants and lower the risk of death.

3 Dec 2019

Inhibition of a protease could improve the treatment of IBD, study shows

Scientists at the Centro Nacional de Investigaciones Cardiovasculares and the Centro de Investigaciones Biológicas of the Consejo Superior de Investigaciones Científicas have identified the protease MT1-MMP as a possible future target for drugs to treat inflammatory bowel disease.

3 Dec 2019

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies.

From Sartorius 3 Dec 2019

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle.

3 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

Research lays foundation for patient-specific 3D-printed meniscus

The human knee joint is the largest and complex joint in the body compared to other joints. It has various hard and soft tissue elements to provide stability and proper functioning including the meniscus.

2 Dec 2019

Scientists sheds light on small protein and its role in immune response

The immune system is the body’s defense against disease-causing pathogens. It works by warding off disease and potentially-damaging foreign bodies. Now, a team of researchers have developed a new method to shed light on the basic defense mechanism of the immune system.

27 Nov 2019

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Oligomerix, Inc., a privately held company pioneering the development of tau oligomer inhibitors for Alzheimer's disease and related neurodegenerative disorders, and the Feinstein Institutes for Medical Research announced today the publication of preclinical data demonstrating that an oral small molecule drug inhibits the formation of neurotoxic tau oligomers in an animal model of tau aggregation most relevant to AD.

26 Nov 2019

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Novoheart, a global stem cell biotechnology company, is pleased to announce a collaboration with global biopharmaceutical company AstraZeneca, in an effort to develop the world’s first human-specific in vitro, functional model of heart failure with preserved ejection fraction (HFpEF), a common condition especially among the elderly and in women, with the reported prevalence approaching 10% in women over the age of 80 years.

26 Nov 2019

in vivo News and Research

Intellegens and Optibrium announce success in the Open Source Malaria global initiative

New model can help study the mechanisms of bone metastasis, tumor immune response

Early adherence step in intestinal transit of Shigella discovered

New discovery may bring scientists a step closer to developing hearing loss treatments

Novel approach to reach the most difficult-to-access physiological locations

New human colon-on-a-chip enables in vitro study of mucus physiology

New treatment approach could improve outcomes for people with cystic fibrosis

Inhibition of a protease could improve the treatment of IBD, study shows

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Research lays foundation for patient-specific 3D-printed meniscus

Scientists sheds light on small protein and its role in immune response

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Apoptosis protein API-5 more markedly expressed in chemoresistant triple-negative breast cancer

Researchers assess safety of conditionally immortalized cells for bioartificial kidney application

PREDiCT: Tumor Models San Francisco Summit 2020

Special protective membrane reduces build-up of fibrotic tissue around pacemakers

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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