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Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Study reveals sex differences in response to drugs targeting tauopathies

Microglia are cells that are central to both brain health as well as disease progression in many neurological conditions.

24 Jan 2023

Study provides an estimate of people in the United States with VEXAS syndrome

About 13,200 men and another 2,300 women in the United States over age 50 are estimated to have VEXAS syndrome, according to a new study led by researchers at NYU Grossman School of Medicine.

24 Jan 2023

Study uncovers protein that acts as a brake for DNA replication

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers.

24 Jan 2023

Researchers review the association between endogenous retrovirus reactivation and aging

Researchers explored the role of endogenous retrovirus (ERV) reactivation in the aging process.

24 Jan 2023

Researchers develop a simple new assay to eliminate heteroresistance in Enterobacter species

Bacteria of the genus Enterobacter are among the most dangerous bacteria associated with hospital infections worldwide.

24 Jan 2023

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Many life-saving drugs directly interact with DNA to treat diseases such as cancer, but scientists have struggled to detect how and why they work – until now.

23 Jan 2023

Review on lateral flow test use spearheaded by SARS-CoV-2 pandemic

Researchers assessed the changing landscape of lateral flow tests (LFTs), and the development of next-generation LFTs based on lessons learnt from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

23 Jan 2023

Novel method makes genetic analyses possible for all regions of the intestine

With its length and multitude of folds and protrusions, the intestine represents the largest contact surface between our body and the food taken up from the outside.

23 Jan 2023

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia.

23 Jan 2023

New resource of digital microbes created with focus on drug metabolism

Researchers at University of Galway associated with APC Microbiome Ireland, a world-leading SFI Research Centre, have created a resource of over 7,000 digital microbes – enabling computer simulations of how drug treatments work and how patients may respond.

20 Jan 2023

Genome News and Research

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Study reveals sex differences in response to drugs targeting tauopathies

Study provides an estimate of people in the United States with VEXAS syndrome

Study uncovers protein that acts as a brake for DNA replication

Researchers review the association between endogenous retrovirus reactivation and aging

Researchers develop a simple new assay to eliminate heteroresistance in Enterobacter species

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Review on lateral flow test use spearheaded by SARS-CoV-2 pandemic

Novel method makes genetic analyses possible for all regions of the intestine

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

New resource of digital microbes created with focus on drug metabolism

UK set to boost genomics expertise through a landmark partnership with Thailand

Comprehensive profiling of human-to-human oral and intestinal microbial transmission

First-ever computer reconstruction replicates the exact chemical and 3D structure of a 'live' virus

10 years of CRISPR genome editing: Advances, limitations, and future potential

Heritable pathogenic defects in genes may increase the risk for sarcomas

Mpox has been silently circulating in non-mpox-endemic nations for 20 years, according to new study

Study reveals how most-resistant pancreatic cancer cells defy treatment

Scientists decipher comprehensive deer tick genome

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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