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White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

As surgeons who take care of cancer patients, we have observed a troubling association between patients who suffer from infections after surgery and the rapid spread of their cancer. We have reported this in lung cancer patients, and others have made these observations in a variety of different cancers. However, the mechanisms responsible for this association are still poorly understood.

16 Jul 2013

Cancer patients who receive chest radiation should be screened for heart disease every 5-10 years

Cancer patients who receive chest radiation should be screened for heart disease every 5-10 years, according to the European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology (ESC) and the American Society of Echocardiography (ASE).

16 Jul 2013

CUMC researchers develop new approach to tailor cancer therapy for individual patient

Columbia University Medical Center (CUMC) researchers are developing a new approach to cancer clinical trials, in which therapies are designed and tested one patient at a time.

16 Jul 2013

FDA approves Gilotrif for patients with late stage non-small cell lung cancer

Companion test also approved to identify appropriate patients The U.S. Food and Drug Administration today approved Gilotrif (afatinib) for patients with late stage (metastatic) non-small cell lung cancer (NSCLC) whose tumors express specific types of epidermal growth factor receptor (EGFR) gene mutations, as detected by an FDA-approved test. Lung cancer is the leading cause of cancer-related death among men and women.

16 Jul 2013

Study shows flavonoid-based nutritional supplements can affect endocrine system

Plant-based diets are healthy. Plants are high in flavonoids. So flavonoids are healthy. At least that's the reasoning of many manufacturers of flavonoid-based nutritional supplements.

16 Jul 2013

Study: Prosthetic valve endocarditis associated with high one-year mortality rate

Prosthetic valve endocarditis (inflammation and infection involving the heart valves and lining of the heart chambers) remains associated with a high one-year mortality rate and early valve replacement does not appear to be associated with lower mortality compared with medical therapy according to a study by Tahaniyat Lalani, M.D., M.H.S., of the Naval Medical Center, Portsmouth, Virginia, and colleagues.

16 Jul 2013

ADC Therapeutics, BZL Biologics sign licensing deal for antibody against PSMA-positive prostate cancers

ADC Therapeutics Sarl, a portfolio company of Auven Therapeutics and the oncology drug development company specializing in proprietary antibody drug conjugates, and BZL Biologics LLC, of New York, today announced an exclusive licensing and collaboration agreement for an antibody against PSMA-positive prostate cancers.

15 Jul 2013

Childhood cancer survivors can still get pregnant despite increased risk of infertility

Although women who survived childhood cancer face an increased risk of infertility, nearly two-thirds of those who tried unsuccessfully to become pregnant for at least a year eventually conceived, according to clinical researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Brigham and Women's Hospital. This is comparable to the rate of eventual pregnancy among all clinically infertile women.

15 Jul 2013

FDA approves QIAGEN’s therascreen EGFR test as companion diagnostic for NSCLC patients

QIAGEN N.V. (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced it has received approval by the U.S. Food and Drug Administration (FDA) to market the therascreen EGFR test as a companion diagnostic to guide the use of Boehringer Ingelheim's new targeted therapy, GILOTRIF™ (afatinib), for treatment of metastatic NSCLC in patients whose tumors have certain EGFR gene mutations.

From QIAGEN Manchester Limited 15 Jul 2013

New theory challenges orthodox view that cancer develops in each host by mutational accidents

A new way to look at cancer -- by tracing its deep evolutionary roots to the dawn of multicellularity more than a billion years ago -- has been proposed by Paul Davies of Arizona State University's Beyond Center for Fundamental Concepts in Science in collaboration with Charles Lineweaver of the Australian National University.

15 Jul 2013

'Defanged' HIV used to deliver gene therapy

Researchers are having success using a "defanged" version of HIV to deliver gene therapy to children suffering from genetic diseases, a development that could improve other such care.

15 Jul 2013

Arthroscopic surgery is a cost-effective approach for patients suffering first shoulder dislocation

Arthroscopic bankart repair surgery is a cost-effective approach for patients suffering their first shoulder dislocation, according to research presented today at the American Orthopaedic Society for Sports Medicine's (AOSSM) Annual Meeting in Chicago, IL.

15 Jul 2013

First Edition: July 12, 2013

Today's early morning highlights from the major news organizations, including articles on data tracking of doctors and comparing the rollout of the Medicare Part D drug plans to implementation of the federal health law.

12 Jul 2013

State highlights: N.Y. expects $20M savings with psychiatric care overhaul; $4M settlement in Mich. over heart procedures

New York plans to overhaul its psychiatric services over the next four years by consolidating 24 inpatient hospitals into 15 regional centers and establishing two dozen outpatient hubs. The plan released to The Associated Press by the Office of Mental Health on Wednesday begins in 2014 and is expected to save $20 million the first year (7/10).

12 Jul 2013

Clinical trial begins on ultrasound in combination with tPA to treat acute ischemic stroke

An international, Phase III clinical trial studying ultrasound in combination with a clot-busting medication to treat acute ischemic stroke has begun at The University of Texas Health Science Center at Houston (UTHealth).

12 Jul 2013

Healthcare system factors may play a role in racial disparities related to kidney failure

Among patients with kidney disease who received specialized pre-dialysis care in a universal healthcare system, blacks experienced faster disease progression than whites, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings suggest that healthcare system factors have less influence on black-white disparities in kidney function decline than other factors.

12 Jul 2013

Seattle Children's leukemia patient has positive response to T-cell therapy

The first patient in a cellular immunotherapy Phase 1 cancer trial at Seattle Children's has had a positive response to T-cell therapy. The 23-year-old patient, Lynsie Conradi, from Bellingham, Wash. received the welcome news yesterday.

12 Jul 2013

Aflibercept drug shows minor added benefit for overall survival in colorectal cancer patients

The drug aflibercept (trade name: Zaltrap) has been approved in Germany since February 2013 in combination with a certain chemotherapy for adults with metastatic colorectal cancer in whom chemotherapy with oxaliplatin could not stop the disease from progressing.

12 Jul 2013

WHO includes new paediatric therapeutic options to EMLc

This week the World Health Organization released its newly updated 4th WHO Model List of Essential Medicines for Children, in which three treatments developed by the Drugs for Neglected Diseases initiative and its partners have now been included.

12 Jul 2013

Patients suffering from severe Charcot-Marie-Tooth disease can benefit from reconstructive surgery

For patients suffering from Charcot-Marie-Tooth disease - a surprisingly common neurological disorder that can cause the feet to become weak and contorted - surgery is considered a last resort. But for patients like Elissa Williams and her brother Kyle, surgery can bring an end to crippling pain and lead to active lives with feet facing forward and balanced on the ground.

12 Jul 2013

Therapy News and Research

White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

Cancer patients who receive chest radiation should be screened for heart disease every 5-10 years

CUMC researchers develop new approach to tailor cancer therapy for individual patient

FDA approves Gilotrif for patients with late stage non-small cell lung cancer

Study shows flavonoid-based nutritional supplements can affect endocrine system

Study: Prosthetic valve endocarditis associated with high one-year mortality rate

ADC Therapeutics, BZL Biologics sign licensing deal for antibody against PSMA-positive prostate cancers

Childhood cancer survivors can still get pregnant despite increased risk of infertility

FDA approves QIAGEN’s therascreen EGFR test as companion diagnostic for NSCLC patients

New theory challenges orthodox view that cancer develops in each host by mutational accidents

'Defanged' HIV used to deliver gene therapy

Arthroscopic surgery is a cost-effective approach for patients suffering first shoulder dislocation

First Edition: July 12, 2013

State highlights: N.Y. expects $20M savings with psychiatric care overhaul; $4M settlement in Mich. over heart procedures

Clinical trial begins on ultrasound in combination with tPA to treat acute ischemic stroke

Healthcare system factors may play a role in racial disparities related to kidney failure

Seattle Children's leukemia patient has positive response to T-cell therapy

Aflibercept drug shows minor added benefit for overall survival in colorectal cancer patients

WHO includes new paediatric therapeutic options to EMLc

Patients suffering from severe Charcot-Marie-Tooth disease can benefit from reconstructive surgery

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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