Sclerosis News and Research

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Mental visual imagery training may improve AM/EFT functioning in RR-MS patients

Patients with relapsing-remitting multiple sclerosis (RR-MS), the most common form of the disease, often have deficits in two neuropsychological functions, autobiographical memory (AM) and episodic future thinking (EFT), which impact quality of life.

26 Aug 2015

Cognitive factors associated with activity, participation in everyday life among people with MS

Kessler Foundation researchers found that processing speed is the primary limiting factor associated with activity and participation in everyday life among people with multiple sclerosis (MS). "Factors that moderate activity limitation and participation restriction in people with multiple sclerosis" was published in the American Journal of Occupational Therapy.

24 Aug 2015

FDA accepts Allergan's resubmission of BOTOX sBLA for treatment of adults with upper limb spasticity

Allergan plc, a leading global pharmaceutical company today announced that the U.S. Food and Drug Administration has accepted the company's resubmission of its Supplemental Biologics License Application (sBLA) for BOTOX (onabotulinumtoxinA) for the treatment of adults with lower limb (involving ankle and toe muscles) spasticity in adults.

20 Aug 2015

Stress hormone cortisol tied to thinking problems in healthy older people

Testing the saliva of healthy older people for the level of the stress hormone cortisol may help identify individuals who should be screened for problems with thinking skills, according to a study published in the August 19, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

20 Aug 2015

Early exposure to inflammatory cytokines can paralyze CD4 T cells

In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help orchestrate the body's response to pathogens and other invaders.

19 Aug 2015

Survey identifies key factors linked to pediatric safety events in out-of-hospital emergent care situations

A national survey of more than 750 emergency medical services providers conducted by researchers at Oregon Health & Science University identified airway management skills, personal anxiety and limited pediatric care proficiency among key factors that may contribute to pediatric safety events for children in out-of-hospital emergent care situations.

19 Aug 2015

Physical activity linked to reduced paediatric MS burden

A cross-sectional study has found an association between moderate or strenuous physical activity and reduced fatigue, lesion volumes and relapse rates in children and adolescents with multiple sclerosis.

18 Aug 2015

Nuclear process in the brain may play critical role in health and disease

Every brain cell has a nucleus, or a central command station. Scientists have shown that the passage of molecules through the nucleus of a star-shaped brain cell, called an astrocyte, may play a critical role in health and disease.

18 Aug 2015

Others consider our moral traits, not memory, to be core component of our identity

We may view our memory as being essential to who we are, but new findings suggest that others consider our moral traits to be the core component of our identity. Data collected from family members of patients suffering from neurodegenerative disease showed that it was changes in moral behavior, not memory loss, that caused loved ones to say that the patient wasn't "the same person" anymore.

18 Aug 2015

Kessler Foundation researcher confirms link between sleep disturbances and MS-related fatigue

Kessler Foundation's Lauren Strober, PhD, explores the association of secondary fatigue and sleep disturbances in multiple sclerosis (MS). "Fatigue in multiple sclerosis: a look at the role of poor sleep" was published in Frontiers in Neurology.

18 Aug 2015

Inhibikase Therapeutics launches observational clinical study in patients who survived PML

Inhibikase Therapeutics, Inc. announces the launch of an observational clinical study in patients who contracted Progressive Multifocal Leukoencephalopathy (PML), the rare and often fatal brain infection that arises as an unintended side effect of some medications used for treatment of Multiple Sclerosis, Crohn's disease, Ulcerative Colitis and certain cancers of the blood and lymph.

13 Aug 2015

Netrin1 protein acts as cellular "marriage broker"

Scientists at the Montreal Neurological Institute and Hospital -The Neuro, at McGill University and the McGill University Health Centre, have made a breakthrough in understanding an important protein that appears to act as a kind of cellular "marriage broker."

13 Aug 2015

Regular exercise benefits children with multiple sclerosis

A new study suggests children with multiple sclerosis (MS) who exercise regularly may have a less active disease. The research is published in the August 12, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

13 Aug 2015

Researchers report role of two gene-regulating molecules in Parkinson's disease

As Parkinson's disease progresses in patients, a puzzling dichotomy plays out in their brains. One set of neurons degenerates, while a similar population nearby is spared the same degree of damage. Why the difference? An answer to this question could clear the way for preventions and treatments for this disease, which impairs movement.

11 Aug 2015

Intrexon, Synthetic Biologics form ECC to develop and commercialize novel biotherapeutics for phenylketonuria

Intrexon Corporation, a leader in synthetic biology, and Synthetic Biologics, Inc., a clinical-stage company focused on developing therapeutics to protect the microbiome while targeting pathogen-specific diseases, today announced an Exclusive Channel Collaboration (ECC) to pursue the development and commercialization of novel biotherapeutics for the treatment of patients with phenylketonuria (PKU), a serious and debilitating metabolic disorder.

10 Aug 2015

Johns Hopkins researchers discover role of TDP-43 protein in autopsy brain cells of patients with ALS

Autopsies of nearly every patient with the lethal neurodegenerative disorder amyotrophic lateral sclerosis (ALS), and many with frontotemporal dementia (FTD), show pathologists telltale clumps of a protein called TDP-43. Now, working with mouse and human cells, Johns Hopkins researchers report they have discovered the normal role of TDP-43 in cells and why its abnormal accumulation may cause disease.

7 Aug 2015

New fly model developed to study motor neuron degeneration

Researchers at the Babraham Institute and University of Massachusetts Medical School in the United States have developed a new model to study motor neuron degeneration and have used this to identify three genes involved in the neurodegeneration process. These findings could have relevance for understanding the progression of amyotrophic lateral sclerosis (ALS) and other forms of motor neuron disease (MND).

7 Aug 2015

Researchers develop new technology to track DNA-protein binding in live cells

Researchers have developed a new technology that precisely marks where groups of regulatory proteins called transcription factors bind DNA in the nuclei of live cells.

7 Aug 2015

Diets high in sodium could be a novel risk factor in development of multiple sclerosis

Here's another reason to put the salt shaker down: New research in mice shows that diets high in sodium may be a novel risk factor in the development of multiple sclerosis (MS) by influencing immune cells that cause the disease. Although this research does implicate salt intake as a risk factor, it is important to note that dietary salt is likely just one of the many environmental factors contributing to this complex disease, and very much influenced by one's genetic background.

6 Aug 2015

Autoantibody status fails to predict death risk in systemic sclerosis with PAH

Anticentromere and isolated nucleolar autoantibodies are prevalent in systemic sclerosis patients with pulmonary arterial hypertension, but they do not predict survival, US research shows.

5 Aug 2015

Sclerosis News and Research

Mental visual imagery training may improve AM/EFT functioning in RR-MS patients

Cognitive factors associated with activity, participation in everyday life among people with MS

FDA accepts Allergan's resubmission of BOTOX sBLA for treatment of adults with upper limb spasticity

Stress hormone cortisol tied to thinking problems in healthy older people

Early exposure to inflammatory cytokines can paralyze CD4 T cells

Survey identifies key factors linked to pediatric safety events in out-of-hospital emergent care situations

Physical activity linked to reduced paediatric MS burden

Nuclear process in the brain may play critical role in health and disease

Others consider our moral traits, not memory, to be core component of our identity

Kessler Foundation researcher confirms link between sleep disturbances and MS-related fatigue

Inhibikase Therapeutics launches observational clinical study in patients who survived PML

Netrin1 protein acts as cellular "marriage broker"

Regular exercise benefits children with multiple sclerosis

Researchers report role of two gene-regulating molecules in Parkinson's disease

Intrexon, Synthetic Biologics form ECC to develop and commercialize novel biotherapeutics for phenylketonuria

Johns Hopkins researchers discover role of TDP-43 protein in autopsy brain cells of patients with ALS

New fly model developed to study motor neuron degeneration

Researchers develop new technology to track DNA-protein binding in live cells

Diets high in sodium could be a novel risk factor in development of multiple sclerosis

Autoantibody status fails to predict death risk in systemic sclerosis with PAH

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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