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HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Neuroblastomas are pediatric tumors that originate from cells of the embryonic nervous system. The disease can take widely varying clinical courses that range from spontaneous regression to fatal outcomes.

2 Jul 2013

Routledge Journals publishes Military Behavioral Health

Routledge Journals is pleased to announce the publication of Military Behavioral Health: An International Journal of Research and Community Study, which is affiliated with the University of Southern California School of Social Work, Center for Innovation and Research on Veterans & Military Families.

2 Jul 2013

Genentech's Perjeta regimen gets FDA Priority Review for HER2-positive early stage breast cancer

Genentech, a member of the Roche Group, today announced that the U.S. Food and Drug Administration has accepted the company's supplemental Biologics License Application for the use of a Perjeta (pertuzumab) regimen before surgery (neoadjuvant treatment) in people with HER2-positive early stage breast cancer.

2 Jul 2013

EGPAF welcomes new HIV/AIDS treatment and prevention guidelines

The Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) welcomes the World Health Organization (WHO)'s new HIV/AIDS treatment and prevention guidelines. For the first time, the 2013 guidelines combine recommendations across the continuum of HIV care and prevention programs, including expanding treatment eligibility for HIV-positive pregnant women, mothers, and children.

2 Jul 2013

Bayer, Onyx submit sNDA to FDA, marketing authorization application to EMA for Nexavar tablets

Bayer HealthCare and Onyx Pharmaceuticals today announced the submission of a supplemental New Drug Application to the U.S. Food and Drug Administration and an application for marketing authorization to the European Medicines Agency for the oral multi-kinase inhibitor Nexavar (sorafenib) tablets for the treatment of locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer.

1 Jul 2013

WHO's new HIV treatment guidelines call for immediate ART for HIV-infected children

The World Health Organization's new HIV treatment guidelines, released today at the 2013 International AIDS Society Conference, include new antiretroviral therapy recommendations for HIV-infected children, and will mean that more children will be on better treatments.

1 Jul 2013

New report shows steady progress in research and development for HIV vaccines

Recent breakthroughs in HIV prevention research have confirmed the promise of new options to help end the AIDS epidemic and highlight the urgent need for ongoing research to develop additional prevention options and support rapid rollout of proven ones.

1 Jul 2013

New WHO guidelines recommend earlier treatment for people living with HIV

New HIV treatment guidelines by WHO recommend offering antiretroviral therapy earlier. Recent evidence indicates that earlier ART will help people with HIV to live longer, healthier lives, and substantially reduce the risk of transmitting HIV to others.

1 Jul 2013

Protein in liver plays a crucial role in mice's pregnancy and human menstrual cycle

A protein first shown to function in the liver plays a crucial role in pregnancy in mice and has a key role in the human menstrual cycle, according to researchers at the University of Montreal. Mice that were genetically engineered not to produce the liver receptor homolog-1 (Lrh-1) molecule were unable to create the uterine conditions necessary for establishing and sustaining pregnancy, resulting in the formation of defective placentas.

1 Jul 2013

Research: Systemic dose of dendritic cells prevent rejection in kidney transplantation

A single systemic dose of special immune cells prevented rejection for almost four months in a preclinical animal model of kidney transplantation, according to experts at the University of Pittsburgh School of Medicine.

1 Jul 2013

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen-receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment.

30 Jun 2013

RPCI scientists assess safety and efficacy of immunotherapy approach to treat advanced melanoma

A new clinical research study at Roswell Park Cancer Institute (RPCI) will assess the safety and efficacy of a novel immunotherapy approach to treating advanced melanoma. Developed at RPCI by Roswell Park researchers, the investigational vaccine shows promise for treating tumors in patients with stage III/stage IV melanoma, and perhaps as a future therapy for other solid-tumor cancers as well.

30 Jun 2013

Transplanted bone marrow stem cells in patients with type 2 diabetes reduce insulin use

A study carried out in India examining the safety and efficacy of self-donated (autologous), transplanted bone marrow stem cells in patients with type 2 diabetes (TD2M), has found that patients receiving the transplants, when compared to a control group of TD2M patients who did not receive transplantation, required less insulin post-transplantation.

30 Jun 2013

Test-based approach of WHO unsuitable for regions where lot of malaria occurs: Research

In view of the sharp rise in treatment costs of malaria, the World Health Organization says that there must be a hard diagnosis before the disease is treated.

29 Jun 2013

Mount Sinai becomes first NYC medical center to use new HeartMate II controller in heart failure patients

The Mount Sinai Medical Center is the first medical center in New York City to offer the newly FDA approved HeartMate II® Pocket Controller™ to help its advanced heart failure patients maintain more active lifestyles.

29 Jun 2013

Researchers complete 25-year follow-up study on infants with iron deficiency in Costa Rica

Iron deficiency is a worldwide problem, especially in developing countries and among infants and pregnant women. In infancy, iron deficiency is associated with poorer cognitive, motor, and social-emotional outcomes. In a new study scheduled for publication in The Journal of Pediatrics, researchers report on a 25-year follow-up of infants studied in Costa Rica for iron deficiency.

29 Jun 2013

Researchers investigate enteral nutrition, caloric requirements among critically ill children

For the first time, researchers investigated enteral nutrition and caloric requirements (CR) among critically ill children in a new report published in the Journal of the Academy of Nutrition and Dietetics. This study also showed the value of including registered dietitians in the medical team.

28 Jun 2013

'Sleep Mask' prototype: The world's first non-invasive treatment for sight loss

Rt Hon David Willetts MP has seen the 'Sleep Mask' prototype - the world's first non-invasive treatment for sight loss that will save the need for expensive hospital treatment - at Northumbria University's Northern Design Centre (NDC).

28 Jun 2013

Rural women with breast cancer less likely to receive radiation therapy after lumpectomy

Rural women with breast cancer are less likely than their urban counterparts to receive recommended radiation therapy after having a lumpectomy, a breast-sparing surgery that removes only tumors and surrounding tissue, a study by Mayo Clinic and others found.

28 Jun 2013

Computer simulation for predicting effectiveness of combination therapies for colon tumors

Scientist at Charité - Universitätsmedizin Berlin have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors. The study has been published in the current issue of the professional journal Molecular Systems Biology*.

28 Jun 2013

Therapy News and Research

HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Routledge Journals publishes Military Behavioral Health

Genentech's Perjeta regimen gets FDA Priority Review for HER2-positive early stage breast cancer

EGPAF welcomes new HIV/AIDS treatment and prevention guidelines

Bayer, Onyx submit sNDA to FDA, marketing authorization application to EMA for Nexavar tablets

WHO's new HIV treatment guidelines call for immediate ART for HIV-infected children

New report shows steady progress in research and development for HIV vaccines

New WHO guidelines recommend earlier treatment for people living with HIV

Protein in liver plays a crucial role in mice's pregnancy and human menstrual cycle

Research: Systemic dose of dendritic cells prevent rejection in kidney transplantation

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

RPCI scientists assess safety and efficacy of immunotherapy approach to treat advanced melanoma

Transplanted bone marrow stem cells in patients with type 2 diabetes reduce insulin use

Test-based approach of WHO unsuitable for regions where lot of malaria occurs: Research

Mount Sinai becomes first NYC medical center to use new HeartMate II controller in heart failure patients

Researchers complete 25-year follow-up study on infants with iron deficiency in Costa Rica

Researchers investigate enteral nutrition, caloric requirements among critically ill children

'Sleep Mask' prototype: The world's first non-invasive treatment for sight loss

Rural women with breast cancer less likely to receive radiation therapy after lumpectomy

Computer simulation for predicting effectiveness of combination therapies for colon tumors

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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