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Hyde Park artist draws daily creative inspiration from chronic health experience

A kidney transplantation means much more than good health to Jason E. Jones. The 53 year-old Hyde Park artist and Loyola Medicine patient draws daily creative inspiration from his chronic health experience.

25 Jun 2016

New study shows microRNAs play important role in inducing asthma

A new study shows that microRNAs, which are small, noncoding RNA molecules that can silence genes, have an important role in inducing asthma.

24 Jun 2016

Researchers identify new potential target for pancreatic cancer treatment

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports.

24 Jun 2016

Novel adaptive mechanisms in hibernating animals may provide clues to mitigate cardiac injury

Novel adaptations discovered in hibernating animals may reveal ways to mitigate injuries associated with strokes, heart attacks and organ transplants, according to researchers at the University of Alaska Fairbanks and Duke University.

23 Jun 2016

Salvage inotuzumab ozogamicin improves ALL outcomes

Compared with standard chemotherapy, treatment with inotuzumab ozogamicin increases the rate of complete remission and allows a higher proportion of patients with relapsed or refractory acute lymphoblastic leukaemia to subsequently receive stem-cell transplantation, research suggests.

22 Jun 2016

Composition of microbiota plays significant role in body's ability to accept transplanted tissue

Researchers from the University of Chicago have shown that microbiota—the bacteria, viruses and other microbes living on the skin and in the digestive system—play an important role in the body's ability to accept transplanted skin and other organs.

22 Jun 2016

Food allergies linked to diet and gut microbiome

The development of food allergies in mice can be linked to what their gut bacteria are being fed, reports a study published June 21 in Cell Reports. Rodents that received a diet with average calories, sugar, and fiber content from birth were shown to have more severe peanut allergies than those that received a high-fiber diet.

21 Jun 2016

Highly efficient bacterial agent could improve treatment of Wilson disease

In the 'Journal of Clinical Investigation', scientists at the Helmholtz Zentrum München describe a small peptide that very efficiently binds excess copper from liver cells. This molecule comes from a bacterium's bag of tricks and could be suitable for treating Wilson disease.

21 Jun 2016

Kidney transplant recipients with inflammation prior to surgery more likely to develop diabetes

Up to 30 percent of people who receive organ transplants will develop diabetes, but researchers are unsure why. Although doctors typically blame immunosuppressive drugs that transplant recipients take to prevent organ rejection, it's unclear why some people develop the lifelong disorder, while others do not.

21 Jun 2016

New blood test could help predict severity of pulmonary arterial hypertension

Johns Hopkins Medicine researchers report that rising blood levels of a protein called hematoma derived growth factor (HDGF) are linked to the increasing severity of pulmonary arterial hypertension, a form of damaging high blood pressure in the lungs.

20 Jun 2016

Elevated levels of CXCL10 protein could help diagnose cGvHD in blood, bone marrow transplant patients

A new study published today in the journal Blood has identified a protein that could diagnose chronic graft-versus-host disease (cGvHD), a serious, long-term complication that affects some patients after a blood and bone marrow transplant.

17 Jun 2016

Absence of one specific species of gut bacteria causes autism-related social deficits in mice

The absence of one specific species of gut bacteria causes social deficits in mice, researchers at Baylor College of Medicine report June 16 in Cell. By adding this bacterial species back to the guts of affected mice, the researchers were able to reverse some of the mice's behavioral deficits, which are reminiscent of symptoms of autism spectrum disorders (ASDs) in humans.

17 Jun 2016

Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

Adaptive Biotechnologies, the leader in combining next-generation sequencing (NGS) and expert bioinformatics to profile T- and B-cell receptors of the adaptive immune system, and collaborators will be presenting five studies demonstrating how Adaptive’s high-throughput sequencing platform enables diagnosis, detection and assessment of prognosis in hematological malignances and has increased sensitivity over flow cytometry.

16 Jun 2016

Salvage alloSCT remains option for progressing CML patients

Research demonstrates the continuing role of allogeneic stem cell transplantation as a salvage option for patients with chronic myeloid leukaemia who progress to accelerated phase or blast crisis after tyrosine kinase inhibitor failure.

15 Jun 2016

Maintenance TKI therapy 'feasible' for high-risk CML patients after allogeneic HSCT

Patients with high-risk chronic myeloid leukaemia who undergo allogeneic haematopoietic stem cell transplantation may benefit from continuing with tyrosine kinase inhibitor therapy, US clinicians believe.

15 Jun 2016

Scientists aim to heal failing heart with the body’s own cells

Babies born with heart defects live longer than ever thanks to advances in the diagnosis and treatment of congenital heart disease. Yet, despite substantial progress, many continue to face bleak odds, lifelong medication, multiple surgeries and progressive heart failure, often requiring a transplant.

15 Jun 2016

Autologous stem cell transplant safe, effective for HIV-associated lymphoma patients

New research published online today in Blood Journal of the American Society of Hematology (ASH), challenges the generally held belief that individuals with HIV and aggressive lymphoma are not candidates for standard treatment.

14 Jun 2016

Inotuzumab ozogamicin study reveals complete remission rates higher than standard therapy for ALL patients

In a randomized Phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with acute lymphoblastic leukemia (ALL) whose disease had relapsed following standard therapies, qualified for stem cell transplants.

13 Jun 2016

Tandem myeloablative ASCT consolidation boosts neuroblastoma outcomes

Research presented at the American Society of Clinical Oncology annual conference suggests that consolidation therapy with tandem compared with single myeloablative autologous stem cell transplant can improve outcomes in paediatric patients with high-risk neuroblastoma.

12 Jun 2016

Immunoablation strengthens haemopoietic stem-cell transplantation effects in MS

Intensifying current transplant conditioning to remove rather than suppress immune cells ahead of autologous haematopoietic stem cell transplantation may result in long-term remission of multiple sclerosis, phase II trial findings show.

10 Jun 2016

Transplant News and Research

Hyde Park artist draws daily creative inspiration from chronic health experience

New study shows microRNAs play important role in inducing asthma

Researchers identify new potential target for pancreatic cancer treatment

Novel adaptive mechanisms in hibernating animals may provide clues to mitigate cardiac injury

Salvage inotuzumab ozogamicin improves ALL outcomes

Composition of microbiota plays significant role in body's ability to accept transplanted tissue

Food allergies linked to diet and gut microbiome

Highly efficient bacterial agent could improve treatment of Wilson disease

Kidney transplant recipients with inflammation prior to surgery more likely to develop diabetes

New blood test could help predict severity of pulmonary arterial hypertension

Elevated levels of CXCL10 protein could help diagnose cGvHD in blood, bone marrow transplant patients

Absence of one specific species of gut bacteria causes autism-related social deficits in mice

Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

Salvage alloSCT remains option for progressing CML patients

Maintenance TKI therapy 'feasible' for high-risk CML patients after allogeneic HSCT

Scientists aim to heal failing heart with the body’s own cells

Autologous stem cell transplant safe, effective for HIV-associated lymphoma patients

Inotuzumab ozogamicin study reveals complete remission rates higher than standard therapy for ALL patients

Tandem myeloablative ASCT consolidation boosts neuroblastoma outcomes

Immunoablation strengthens haemopoietic stem-cell transplantation effects in MS

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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