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Clinical data of cabozantinib to be presented at ASCO meeting

Exelixis, Inc. announced today that cabozantinib will be the subject of nine separate data presentations at the upcoming 2013 Annual Meeting of the American Society of Clinical Oncology.

8 May 2013

New skin cancer drug successfully tested in humans

A new class of drug targeting skin cancer's genetic material has been successfully tested in humans for the first time, opening the way to new treatments for a range of conditions from skin cancers to eye diseases.

8 May 2013

Study to examine role of arts, humanities in improving mental health and well-being

An innovative study led by The University of Nottingham is to investigate whether arts and humanities can help improve the mental health and well-being of patients and carers alike.

8 May 2013

Isis begins clinical study of ISIS-STAT3 in patients with metastatic liver cancer

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 1b/2a clinical study of ISIS-STAT3Rx in patients with advanced metastatic hepatocellular carcinoma (HCC).

7 May 2013

Janssen enrolls patients in expanded access program for mantle cell lymphoma

Janssen Research & Development, LLC (Janssen) today announced patients are now enrolling in a multicenter, open-label expanded access program (EAP) in the United States for the investigational oral Bruton's Tyrosine Kinase (BTK) inhibitor ibrutinib, which is being jointly developed by Janssen and Pharmacyclics, Inc.

7 May 2013

ECMO can be used on neonates with severe respiratory failure until lung transplantation, say scientists

Adults with end-stage respiratory failure and pulmonary hypertension requiring ECMO (extracorporeal membrane oxygenation) have been "bridged" toward lung transplantation with novel lung assist devices such as the Novalung.

7 May 2013

Biomedical engineers grow 3D human heart muscle that acts just like natural tissue

Duke University biomedical engineers have grown three-dimensional human heart muscle that acts just like natural tissue. This advancement could be important in treating heart attack patients or in serving as a platform for testing new heart disease medicines.

7 May 2013

Breast milk might prevent premature babies from deadly intestinal condition

An ingredient that naturally occurs in breast milk might be used to prevent premature babies from developing a deadly intestinal condition that currently is largely incurable, according to researchers at the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh of UPMC in this week's online early edition of the Proceedings of the National Academy of Sciences.

7 May 2013

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Aileron Therapeutics, Inc. today announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.

7 May 2013

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

Kinase inhibitors are molecules that block the activity of kinases. Kinases are a specific class of enzymes. They are extremely important in signal transduction processes in the human body meaning that they actually regulate most of the physiological processes that take place in the body.

7 May 2013

AUA and ASTRO release new guideline on adjuvant and salvage radiotherapy after prostatectomy

The American Society for Radiation Oncology (ASTRO) and the American Urological Association (AUA) are pleased to announce the publication of the joint guideline on radiation therapy after prostatectomy for patients with and without evidence of prostate cancer recurrence.

7 May 2013

Implantation of new mechanical heart valve reduces anticoagulation therapy in AVR patients

For more than 40 years, patients under 65 years of age requiring heart valve replacement have had to choose between a mechanical valve that offers life-long durability but requires aggressive warfarin anticoagulation or a biological (cow or pig) valve that will wear out in 10-20 years but does not require anticoagulation.

7 May 2013

New form of electroconvulsive therapy could prevent adverse cognitive side effects

Electroconvulsive therapy (ECT) is the most effective acute treatment for severe major depression. However, even with newer forms of ECT, there remains a significant risk of adverse cognitive effects, particularly memory problems.

7 May 2013

Researchers publish new Canadian guidelines for diagnosis and treatment of fibromyalgia

Physicians from the McGill University Health Centre (MUHC) and the University of Calgary have published a review article in the CMAJ (Canadian Medical Association Journal) to help family doctors diagnose and treat fibromyalgia.

7 May 2013

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

NI Research, the leading publisher of independent research on the neurotherapeutics industry, has released the May issue of NeuroPerspective, which reviews the status and prospects of therapeutics for Parkinson's.

7 May 2013

Prior administration of erythropoietin reduces need for blood transfusions

Anemia increases operative mortality and morbidity in non-cardiac and cardiac surgical procedures. Anemic surgical patients may require more blood transfusions, raising the risk of transfusion-related complications and increasing costs.

7 May 2013

Clinical trial recruits patients with lower back pain to investigate non-surgical treatment

A clinical trial being conducted at the University of British Columbia, sponsored by Active-O, is currently recruiting patients suffering from lower back pain caused by a contained herniated disc to investigate a new, non-surgical treatment.

6 May 2013

Over 90% of medical specialists do not follow ADHD guidelines

A recent study by pediatricians from the Cohen Children's Medical Center of New York examined to what extent pediatric physicians adhere to American Academy of Pediatrics (AAP) clinical guidelines regarding pharmacotherapy in treating young patients with Attention Deficit Hyperactivity Disorder (ADHD).

6 May 2013

Oxygenation targets and outcomes in premature infants

In a randomized trial performed to help resolve the uncertainty about the optimal oxygen saturation therapy in extremely preterm infants, researchers found that targeting saturations of 85 percent to 89 percent compared with 91 percent to 95 percent had no significant effect on the rate of death or disability at 18 months, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the Pediatric Academic Societies annual meeting.

6 May 2013

Oral drops provide a safe and effective alternative for allergy sufferers

Allergy shots are commonly used to treat children with severe environmental allergies and asthma, but under-the-tongue drops may offer yet another beneficial - and stick-free - option for pediatric allergy sufferers, according to a Johns Hopkins Children's Center review of existing scientific evidence.

6 May 2013

Therapy News and Research

Clinical data of cabozantinib to be presented at ASCO meeting

New skin cancer drug successfully tested in humans

Study to examine role of arts, humanities in improving mental health and well-being

Isis begins clinical study of ISIS-STAT3 in patients with metastatic liver cancer

Janssen enrolls patients in expanded access program for mantle cell lymphoma

ECMO can be used on neonates with severe respiratory failure until lung transplantation, say scientists

Biomedical engineers grow 3D human heart muscle that acts just like natural tissue

Breast milk might prevent premature babies from deadly intestinal condition

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

AUA and ASTRO release new guideline on adjuvant and salvage radiotherapy after prostatectomy

Implantation of new mechanical heart valve reduces anticoagulation therapy in AVR patients

New form of electroconvulsive therapy could prevent adverse cognitive side effects

Researchers publish new Canadian guidelines for diagnosis and treatment of fibromyalgia

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

Prior administration of erythropoietin reduces need for blood transfusions

Clinical trial recruits patients with lower back pain to investigate non-surgical treatment

Over 90% of medical specialists do not follow ADHD guidelines

Oxygenation targets and outcomes in premature infants

Oral drops provide a safe and effective alternative for allergy sufferers

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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